Fosamprenavir
- Generic Name
- Fosamprenavir
- Brand Names
- Lexiva, Telzir
- Drug Type
- Small Molecule
- Chemical Formula
- C25H36N3O9PS
- CAS Number
- 226700-79-4
- Unique Ingredient Identifier
- WOU1621EEG
- Background
Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease.
- Indication
Indicated in combination with other antiretroviral agents for the treatment of human immunodeficiency virus (HIV-1) infection, as well as postexposure prophylaxis of HIV infection in individuals who have had occupational or nonoccupational exposure to potentially infectious body fluids of a person known to be infected with HIV when that exposure represents a substantial risk for HIV transmission. The use of fosamprenavir is pending revision due to a potential association between the drug and myocardial infarction and dyslipidemia in HIV infected adults.
- Associated Conditions
- Human Immunodeficiency Virus Type 1 (HIV-1) Infection
Oral Fosamprenavir + Sodium Alginate for GERD
- Conditions
- Refractory Gastroesophageal Reflux DiseaseGastroesophageal Reflux Disease
- Interventions
- Other: Placebo
- First Posted Date
- 2024-11-25
- Last Posted Date
- 2024-12-05
- Lead Sponsor
- Medical College of Wisconsin
- Target Recruit Count
- 60
- Registration Number
- NCT06704100
- Locations
- 🇺🇸
Medical College of Wisconsin, Milwaukee, Wisconsin, United States
Oral Fosamprenavir-Sodium Alginate for LPR
- Conditions
- Laryngopharyngeal Reflux
- Interventions
- Other: Placebo
- First Posted Date
- 2020-05-12
- Last Posted Date
- 2025-05-08
- Lead Sponsor
- Medical College of Wisconsin
- Target Recruit Count
- 104
- Registration Number
- NCT04383262
- Locations
- 🇺🇸
Froedtert Hospital, Milwaukee, Wisconsin, United States
HCV Evolution in HIV/HCV (Genotype 1) Coinfected Patients Treated With Fosamprenavir
- First Posted Date
- 2010-10-18
- Last Posted Date
- 2014-05-30
- Lead Sponsor
- Fundacion SEIMC-GESIDA
- Target Recruit Count
- 42
- Registration Number
- NCT01222611
- Locations
- 🇪🇸
Hospital Clínico San Carlos, Madrid, Spain
🇪🇸Hospital Gregorio Marañón, Madrid, Spain
🇪🇸Hospital La Paz, Madrid, Spain
GSK1349572 Drug Interaction Study With Fosamprenavir/Ritonavir
- Conditions
- Infections, Human Immunodeficiency Virus and Herpesviridae
- Interventions
- First Posted Date
- 2010-09-24
- Last Posted Date
- 2017-01-19
- Lead Sponsor
- ViiV Healthcare
- Target Recruit Count
- 27
- Registration Number
- NCT01209065
- Locations
- 🇺🇸
GSK Investigational Site, Buffalo, New York, United States
Pharmacokinetic Study of Posaconazole Boosted Fosamprenavir
- Conditions
- Fungal InfectionHIV Infection
- Interventions
- First Posted Date
- 2009-01-06
- Last Posted Date
- 2020-11-12
- Lead Sponsor
- Radboud University Medical Center
- Target Recruit Count
- 24
- Registration Number
- NCT00817765
- Locations
- 🇳🇱
Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands
An Interaction Study to Assess Drug Levels in Fasting Healthy Adult Subjects
- Conditions
- Healthy
- Interventions
- First Posted Date
- 2008-12-04
- Last Posted Date
- 2016-01-29
- Lead Sponsor
- Garden State Infectious Disease Associates, PA
- Target Recruit Count
- 45
- Registration Number
- NCT00802074
- Locations
- 🇺🇸
Garden State Infectious Disease Associates, PA, Voorhees, New Jersey, United States
VX-950-TiDP24-C124: A Phase I Trial to Investigate the Potential Pharmacokinetic Interactions Between Telaprevir and Darunavir/Ritonavir and Between Telaprevir and Fosamprenavir/Ritonavir at Steady-state.
- Conditions
- HIVTelaprevirHepatitis C
- First Posted Date
- 2008-10-17
- Last Posted Date
- 2010-12-17
- Lead Sponsor
- Tibotec BVBA
- Target Recruit Count
- 40
- Registration Number
- NCT00775125
An Interaction Study to Assess Drug Levels in Healthy Adult Subjects
- First Posted Date
- 2008-10-02
- Last Posted Date
- 2016-01-29
- Lead Sponsor
- Garden State Infectious Disease Associates, PA
- Target Recruit Count
- 45
- Registration Number
- NCT00764465
- Locations
- 🇺🇸
Garden State Infectious Disease Associates,PA, Voorhees, New Jersey, United States
An Interaction Study to Assess Drug Levels in Healthy Adult Subjects
- Conditions
- Healthy
- Interventions
- First Posted Date
- 2008-02-14
- Last Posted Date
- 2016-01-29
- Lead Sponsor
- Garden State Infectious Disease Associates, PA
- Target Recruit Count
- 44
- Registration Number
- NCT00614991
Co-Administration Of Fosamprenavir With Methadone: A Drug Interaction Study.
- Conditions
- Healthy Subjects
- First Posted Date
- 2007-06-01
- Last Posted Date
- 2009-02-23
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 20
- Registration Number
- NCT00481182
- Locations
- 🇺🇸
GSK Investigational Site, Buffalo, New York, United States
Drug Development Updates
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