Cidofovir
- Generic Name
- Cidofovir
- Brand Names
- Vistide
- Drug Type
- Small Molecule
- Chemical Formula
- C8H14N3O6P
- CAS Number
- 113852-37-2
- Unique Ingredient Identifier
- 768M1V522C
- Background
Cidofovir is an injectable antiviral medication employed in the treatment of cytomegalovirus (CMV) retinitis in patients diagnosed with AIDS. It suppresses CMV replication through selective inhibition of viral DNA synthesis. It was manufactured by Gilead and initially approved by the FDA in 1996, but has since been discontinued.
- Indication
用于治疗免疫功能缺陷患者不能耐受更昔洛韦和膦甲酸钠治疗或治疗无效的巨细胞病毒感染。
- Associated Conditions
- Cytomegalovirus Retinitis, Herpes Simplex Virus, Monkeypox, Variola Major (Smallpox)
Cidofovir as a Treatment for Herpes Simplex in Patients With AIDS
- Conditions
- HIV InfectionsHerpes Simplex
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Gilead Sciences
- Registration Number
- NCT00002181
- Locations
- 🇺🇸
HIV Primary Care & Consult, Santa Rosa, California, United States
🇺🇸AIDS Healthcare Foundation Labs, Los Angeles, California, United States
🇺🇸Dr Susan M Diamond, Dallas, Texas, United States
A Phase I/II Study of the Safety and Efficacy of Topical 1-(S)-(3-Hydroxy-2-Phosphonylmethoxypropyl)Cytosine Dihydrate (Cidofovir; HPMPC) in the Treatment of Refractory Mucocutaneous Herpes Simplex Disease in Patients With AIDS
- Conditions
- Herpes SimplexHIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Gilead Sciences
- Target Recruit Count
- 30
- Registration Number
- NCT00002116
- Locations
- 🇺🇸
Mount Zion Med Ctr / UCSF, San Francisco, California, United States
🇺🇸Los Angeles County - USC Med Ctr, Los Angeles, California, United States
🇺🇸Johns Hopkins Hosp, Baltimore, Maryland, United States
An Open-Label Study of the Safety and Efficacy of Cidofovir for the Treatment of Relapsing Cytomegalovirus Retinitis in Patients With AIDS
- Conditions
- Cytomegalovirus RetinitisHIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Gilead Sciences
- Target Recruit Count
- 100
- Registration Number
- NCT00002142
- Locations
- 🇺🇸
Besselaar Associates, Princeton, New Jersey, United States
The Safety and Effectiveness of Cidofovir in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS
- Conditions
- Cytomegalovirus RetinitisHIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Gilead Sciences
- Target Recruit Count
- 48
- Registration Number
- NCT00002437
- Locations
- 🇬🇧
Charing Cross and Westminster Med School, London SW 10, United Kingdom
🇺🇸Mount Zion Med Ctr, San Francisco, California, United States
🇺🇸Univ of North Carolina Hosps, Chapel Hill, North Carolina, United States
A Study of Cidofovir in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS
- Conditions
- Cytomegalovirus RetinitisHIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Gilead Sciences
- Registration Number
- NCT00002384
The Safety and Effectiveness of Cidofovir in the Treatment of Venereal Warts in HIV-Infected Patients
- Conditions
- HIV InfectionsCondyloma Acuminata
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Gilead Sciences
- Target Recruit Count
- 40
- Registration Number
- NCT00002327
- Locations
- 🇺🇸
Dr Brad Bowden, Houston, Texas, United States
🇺🇸Pacific Med Ctr, Seattle, Washington, United States
🇺🇸Houston Clinical Research Network, Houston, Texas, United States
A Study of Cidofovir in HIV-Infected Children With Cytomegalovirus (CMV) Disease
- Conditions
- Cytomegalovirus InfectionsCytomegalovirus RetinitisHIV Infections
A Study to Evaluate the Use of Cidofovir (an Experimental Drug) for the Treatment of Progressive Multifocal Leukoencephalopathy (PML) in AIDS Patients
- Conditions
- HIV InfectionsLeukoencephalopathy, Progressive Multifocal
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-10-29
- Target Recruit Count
- 24
- Registration Number
- NCT00000945
- Locations
- 🇺🇸
Rush Presbyterian - Saint Luke's Med Ctr, Chicago, Illinois, United States
🇺🇸San Francisco AIDS Clinic / San Francisco Gen Hosp, San Francisco, California, United States
🇺🇸Univ of Alabama at Birmingham, Birmingham, Alabama, United States
Phase II Randomized Study of Cidofovir for Peripheral Cytomegalovirus Retinitis
- Conditions
- Cytomegalovirus RetinitisAcquired Immunodeficiency Syndrome
- First Posted Date
- 2000-02-25
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- National Center for Research Resources (NCRR)
- Target Recruit Count
- 90
- Registration Number
- NCT00004794
Studies of the Ocular Complications of AIDS (SOCA)--HPMPC Peripheral CMV Retinitis Trial (HPCRT)
- First Posted Date
- 1999-09-24
- Last Posted Date
- 2015-11-17
- Lead Sponsor
- Johns Hopkins Bloomberg School of Public Health
- Target Recruit Count
- 64
- Registration Number
- NCT00000142
Drug Development Updates
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