MedPath

Cidofovir

Generic Name
Cidofovir
Brand Names
Vistide
Drug Type
Small Molecule
Chemical Formula
C8H14N3O6P
CAS Number
113852-37-2
Unique Ingredient Identifier
768M1V522C
Background

Cidofovir is an injectable antiviral medication employed in the treatment of cytomegalovirus (CMV) retinitis in patients diagnosed with AIDS. It suppresses CMV replication through selective inhibition of viral DNA synthesis. It was manufactured by Gilead and initially approved by the FDA in 1996, but has since been discontinued.

Indication

用于治疗免疫功能缺陷患者不能耐受更昔洛韦和膦甲酸钠治疗或治疗无效的巨细胞病毒感染。

Associated Conditions
Cytomegalovirus Retinitis, Herpes Simplex Virus, Monkeypox, Variola Major (Smallpox)
Associated Therapies
-

A Study to Evaluate the Use of Cidofovir (an Experimental Drug) for the Treatment of Progressive Multifocal Leukoencephalopathy (PML) in AIDS Patients

Not Applicable
Completed
Conditions
HIV Infections
Leukoencephalopathy, Progressive Multifocal
First Posted Date
2001-08-31
Last Posted Date
2021-10-29
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
24
Registration Number
NCT00000945
Locations
🇺🇸

Rush Presbyterian - Saint Luke's Med Ctr, Chicago, Illinois, United States

🇺🇸

San Francisco AIDS Clinic / San Francisco Gen Hosp, San Francisco, California, United States

🇺🇸

Univ of Alabama at Birmingham, Birmingham, Alabama, United States

and more 16 locations

A Study of Cidofovir in HIV-Infected Children With Cytomegalovirus (CMV) Disease

Phase 1
Withdrawn
Conditions
Cytomegalovirus Infections
Cytomegalovirus Retinitis
HIV Infections
First Posted Date
2001-08-31
Last Posted Date
2021-10-29
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Registration Number
NCT00000881

Comparison of Two Drugs, Cidofovir and Ganciclovir, in Treating Patients With AIDS Who Have CMV Retinitis

Phase 4
Completed
Conditions
Cytomegalovirus Retinitis
HIV Infections
First Posted Date
2001-08-31
Last Posted Date
2011-02-23
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
300
Registration Number
NCT00000894
Locations
🇺🇸

Cornell Univ Med Ctr, New York, New York, United States

🇺🇸

Julio Arroyo, West Columbia, South Carolina, United States

🇺🇸

New York Hosp / Cornell Med Ctr, New York, New York, United States

and more 9 locations

Treatment With Cidofovir for Children With Laryngeal Papillomatosis (Warts in the Throat)

Phase 1
Completed
Conditions
Papilloma
First Posted Date
2001-08-31
Last Posted Date
2010-08-27
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
36
Registration Number
NCT00001126
Locations
🇺🇸

NIAID/DMID/CASG Central Unit, Birmingham, Alabama, United States

Phase II Randomized Study of Cidofovir for Peripheral Cytomegalovirus Retinitis

Phase 2
Completed
Conditions
Cytomegalovirus Retinitis
Acquired Immunodeficiency Syndrome
First Posted Date
2000-02-25
Last Posted Date
2005-06-24
Lead Sponsor
National Center for Research Resources (NCRR)
Target Recruit Count
90
Registration Number
NCT00004794

Studies of the Ocular Complications of AIDS (SOCA)--HPMPC Peripheral CMV Retinitis Trial (HPCRT)

Phase 2
Completed
Conditions
CMV Cytomegalovirus Retinitis
HIV Infections
Interventions
First Posted Date
1999-09-24
Last Posted Date
2015-11-17
Lead Sponsor
Johns Hopkins Bloomberg School of Public Health
Target Recruit Count
64
Registration Number
NCT00000142
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