Dienogest
- Generic Name
- Dienogest
- Brand Names
- Natazia, Visanne
- Drug Type
- Small Molecule
- Chemical Formula
- C20H25NO2
- CAS Number
- 65928-58-7
- Unique Ingredient Identifier
- 46M3EV8HHE
- Background
Dienogest is an orally-active semisynthetic progestogen which also possesses the properties of 17α-hydroxyprogesterone. It is a derivative of 19-nortestosterone and has antiandrogenic properties. It is primarily used as a contraceptive in combination with ethinylestradiol, or in other combination form pills approved in United States and Europe however it is not available in the US by itself. In Europe, Australia, Malaysia, Singapore and Japan, dienogest single therapy is an approved treatment for endometriosis to alleviate painful symptoms of endometriosis and reduce endometriotic lesions . Dienogest is commonly marketed as Visanne, Natazia and Qlaira.
- Indication
Indicated for use as the treatment of endometriosis alone and as a contraceptive in combination with ethinylestradiol.
- Associated Conditions
- Hypermenorrhea, Pain
- Associated Therapies
- Contraception, Oral Contraceptives
Ttt of Adenomyosis
- Conditions
- Adenomyosis
- Interventions
- Procedure: UAE
- First Posted Date
- 2024-12-06
- Last Posted Date
- 2024-12-06
- Lead Sponsor
- Al-Azhar University
- Target Recruit Count
- 100
- Registration Number
- NCT06719934
- Locations
- 🇪🇬
Al Azhar university, Assuit, Egypt
Comparison Between the Effects of Implantable Gestrinone and Oral Dienogest in the Treatment of Endometriosis
- Conditions
- Endometriosis
- Interventions
- First Posted Date
- 2024-08-09
- Last Posted Date
- 2024-08-09
- Lead Sponsor
- Bio Meds Pharmaceutica Ltda
- Target Recruit Count
- 70
- Registration Number
- NCT06543550
- Locations
- 🇧🇷
Dra Juliana Bicca Endocrinologia e Medicina Funcional LTDA, São Paulo, Brazil
🇧🇷Gm Ignacio Atividade Medica LTDA, Brasília, Distrito Federal, Brazil
🇧🇷Jpml Clinica Medica LTDA, São José dos Campos, São Paulo, Brazil
Salivary microRNA in Endometriosis: Correlation With Response to Progestin Therapy
- First Posted Date
- 2024-05-16
- Last Posted Date
- 2025-04-02
- Lead Sponsor
- University of Udine
- Target Recruit Count
- 90
- Registration Number
- NCT06414720
- Locations
- 🇮🇹
University of Udine, Udine, UD, Italy
Comparing the Safety and Efficacy in the Use of Hormonal Therapy on Endometriosis Patients After Conservative Surgery
- Conditions
- Endometriosis Ovary
- Interventions
- First Posted Date
- 2023-11-24
- Last Posted Date
- 2024-12-11
- Lead Sponsor
- Universitas Diponegoro
- Target Recruit Count
- 80
- Registration Number
- NCT06145438
- Locations
- 🇮🇩
Kariadi Hospital, Semarang, Central Java, Indonesia
Evaluation of Using Dienogest and N-Acetyl Cysteine on the Volume of Uterine Leiomyoma
- First Posted Date
- 2023-11-03
- Last Posted Date
- 2024-12-16
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 40
- Registration Number
- NCT06115408
- Locations
- 🇪🇬
Ainshams University, Cairo, Egypt
Adenomyosis and ART
- Conditions
- Adenomyosis
- Interventions
- Drug: long GnRH agonist or flexible GnRH antagonist protocol.
- First Posted Date
- 2023-07-10
- Last Posted Date
- 2023-07-10
- Lead Sponsor
- Azienda Ospedaliero-Universitaria di Modena
- Target Recruit Count
- 500
- Registration Number
- NCT05937490
- Locations
- 🇮🇹
Azienda Ospedaliero-Universitaria di Modena, Modena, Italy
Dienogest in Perimenopausal Women With Adenomyosis
- First Posted Date
- 2023-03-02
- Last Posted Date
- 2023-03-02
- Lead Sponsor
- National Taiwan University Hospital
- Target Recruit Count
- 87
- Registration Number
- NCT05751876
- Locations
- 🇨🇳
National Taiwan University Hospital, Taipei, Taiwan
Comparisons of the Therapeutic Effects of Dienogest and Danazol on Endometriosis
- First Posted Date
- 2023-01-26
- Last Posted Date
- 2023-03-29
- Lead Sponsor
- Far Eastern Memorial Hospital
- Target Recruit Count
- 120
- Registration Number
- NCT05697471
- Locations
- 🇨🇳
Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Banqiao, New Taipei, Taiwan
Effect of Management of the Endometrioma on Ovarian Reserve
- Conditions
- Endometrioma
- First Posted Date
- 2022-12-05
- Last Posted Date
- 2023-05-16
- Lead Sponsor
- University of Valencia
- Target Recruit Count
- 100
- Registration Number
- NCT05637073
- Locations
- 🇵🇱
University Hospital Poznan, Poznan, Poland
🇪🇸Hosp Clinico Universitario-INCLIVA, Valencia, Spain
The Effect of Dienogest vs. Norethindrone Acetate Treatment in Endometriosis
- Conditions
- Endometriosis
- Interventions
- First Posted Date
- 2022-07-27
- Last Posted Date
- 2023-07-21
- Lead Sponsor
- Uludag University
- Target Recruit Count
- 70
- Registration Number
- NCT05476172
- Locations
- 🇹🇷
Uludag University, Bursa, Nilufer, Turkey
Drug Development Updates
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