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Ketorolac

Generic Name
Ketorolac
Brand Names
Acular, Acuvail, Omidria, Readysharp Anesthetics Plus Ketorolac, Sprix, Toradol, Toronova Suik
Drug Type
Small Molecule
Chemical Formula
C15H13NO3
CAS Number
74103-06-3
Unique Ingredient Identifier
YZI5105V0L

Overview

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.

Background

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.

Indication

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and has antipyretic, analgesic and anti-inflammatory properties. It is indicated for short term management of acute pain that requires the calibre of pain management offered by opioids. Clinicians may choose to initiate ketorolac to manage post-operative pain, spinal and soft tissue pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders and headaches among other ailments. Regardless of the etiology of pain, patients should use the lowest possible dose, and avoid using ketorolac for an extended period of time (ideally ≤ 5 days). A benefit of choosing ketorolac over other analgesics with similar potency is that that there does not appear to be a risk of dependence or tolerance with ketorolac use.

Associated Conditions

  • Acute Migraine
  • Eye Pain
  • Inflammation
  • Macular Edema, Cystoid
  • Ocular Itching
  • Pericarditis Acute
  • Pseudophakic Cystoid Macular Oedema
  • Severe Acute Pain
  • Acute, moderate Pain
  • Chronic aphakic cystoid macular edema
  • Intraoperative miosis
  • Postoperative ocular pain

Clinical Trials

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FDA Drug Approvals

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Approved Product
Manufacturer
NDC Code
Route
Strength
Effective Date
Camber Pharmaceuticals, Inc.
31722-306
INTRAVENOUS, INTRAMUSCULAR
30 mg in 1 mL
7/4/2023
Mylan Pharmaceuticals Inc.
0378-1134
ORAL
10 mg in 1 1
7/13/2015
Prescription Care LLC
70486-003
TOPICAL
0.09 g in 30 mL
8/19/2016
Sagent Pharmaceuticals
25021-701
INTRAVENOUS, INTRAMUSCULAR
30 mg in 1 mL
6/20/2023
A-S Medication Solutions
50090-4635
INTRAVENOUS, INTRAMUSCULAR
30 mg in 1 mL
6/20/2019
Fresenius Kabi USA, LLC
63323-161
INTRAVENOUS, INTRAMUSCULAR
15 mg in 1 mL
11/18/2022
Proficient Rx LP
71205-116
INTRAVENOUS, INTRAMUSCULAR
30 mg in 1 mL
12/1/2018
Direct_Rx
72189-371
ORAL
10 mg in 1 1
12/8/2023
A-S Medication Solutions
50090-5013
INTRAVENOUS, INTRAMUSCULAR
30 mg in 1 mL
1/15/2017
Fresenius Kabi USA, LLC
63323-162
INTRAMUSCULAR
30 mg in 1 mL
11/18/2022

EMA Drug Approvals

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Approved Product
Authorization Holder
Status
Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

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Manufacturer
Approval Number
Dosage Form
Strength
Approval Date
No HSA approvals found for this drug.

NMPA Drug Approvals

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Company
Approval Number
Drug Type
Dosage Form
Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

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Company
Licence No.
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Registration Date
No PPB approvals found for this drug.

TGA Drug Approvals

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