Impact of Local Anesthetic Wound Infiltration on Postoperative Pain Following Cesarean Delivery
Overview
- Phase
- Phase 4
- Intervention
- Ropivacaine
- Conditions
- Pain
- Sponsor
- Duke University
- Enrollment
- 84
- Locations
- 1
- Primary Endpoint
- Pain Score on Movement (Sitting in Bed From a Supine Position)
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
The purpose of this study is to determine if the infusion of the local anesthetic ropivacaine (a numbing medicine) and the non-steroidal anti-inflammatory drug ketorolac (a pain killer similar to ibuprofen) through a catheter placed along the cesarean delivery incision, will reduce the pain experienced after cesarean section and need for narcotic pain medicine.
Investigators
Eligibility Criteria
Inclusion Criteria
- •American Society of Anesthesiology (ASA) class 1,2, and 3
- •English speaking women at a gestational age \> 37 weeks
- •scheduled for cesarean delivery under spinal or combined spinal epidural anesthesia
Exclusion Criteria
- •BMI \> 50 kg/m2
- •history of intravenous drug or opioid abuse
- •previous history of chronic pain syndrome
- •history of opioid use in the past week
- •allergy or contraindication to any of the study medications
- •non-English speaking
Arms & Interventions
Ropivacaine
Subjects will receive 440 mg ropivacaine and 30 mg ketorolac. Infusion of study medication will start after the skin is sutured and will continue for 48 hours after cesarean delivery.
Intervention: Ropivacaine
Ropivacaine
Subjects will receive 440 mg ropivacaine and 30 mg ketorolac. Infusion of study medication will start after the skin is sutured and will continue for 48 hours after cesarean delivery.
Intervention: Ketorolac
Placebo
Subjects will receive saline placebo. Infusion of study medication will start after the skin is sutured and will continue for 48 hours after cesarean delivery.
Intervention: Placebo
Outcomes
Primary Outcomes
Pain Score on Movement (Sitting in Bed From a Supine Position)
Time Frame: 24 hours after surgery
Score reported on a scale of 0-10, with 0 being none and 10 being the worst imaginable
Secondary Outcomes
- Time to First Rescue Analgesic(48 hours)
- Number of Subjects Experiencing Nausea(48 hours)
- Patient Satisfaction With Postoperative Analgesia on a 0-10 Scale(48 hours)
- Postpartum Depression, as Measured by the Edinburgh Postnatal Depression Scale(6 months)
- Pain Score on Movement(48 hours after surgery)
- Pain Scores at Rest(48 hours)
- Opioid Consumption(48 hours)
- Number of Subjects Experiencing Pruritus(48 hours)
- Number of Subjects Experiencing Vomiting(48 hours)
- Number of Subjects With Chronic Pain(6 months)