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Ketorolac

Generic Name
Ketorolac
Brand Names
Acular, Acuvail, Omidria, Readysharp Anesthetics Plus Ketorolac, Sprix, Toradol, Toronova Suik
Drug Type
Small Molecule
Chemical Formula
C15H13NO3
CAS Number
74103-06-3
Unique Ingredient Identifier
YZI5105V0L
Background

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.

It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.

Indication

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and has antipyretic, analgesic and anti-inflammatory properties. It is indicated for short term management of acute pain that requires the calibre of pain management offered by opioids. Clinicians may choose to initiate ketorolac to manage post-operative pain, spinal and soft tissue pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders and headaches among other ailments. Regardless of the etiology of pain, patients should use the lowest possible dose, and avoid using ketorolac for an extended period of time (ideally ≤ 5 days). A benefit of choosing ketorolac over other analgesics with similar potency is that that there does not appear to be a risk of dependence or tolerance with ketorolac use.

Associated Conditions
Acute Migraine, Eye Pain, Inflammation, Macular Edema, Cystoid, Ocular Itching, Pericarditis Acute, Pseudophakic Cystoid Macular Oedema, Severe Acute Pain, Acute, moderate Pain, Chronic aphakic cystoid macular edema, Intraoperative miosis, Postoperative ocular pain

Nasal Fentanyl And Renal Colic

Not Applicable
Completed
Conditions
Acute Renal Colic
Interventions
First Posted Date
2011-04-20
Last Posted Date
2011-04-20
Lead Sponsor
Valduce Hospital
Target Recruit Count
65
Registration Number
NCT01339624
Locations
🇮🇹

Valduce Hospital, Como, Italy

Disposition of Intravenous Ketorolac

Phase 4
Completed
Conditions
Postoperative Pain
Interventions
First Posted Date
2011-02-08
Last Posted Date
2011-12-13
Lead Sponsor
Universitaire Ziekenhuizen KU Leuven
Target Recruit Count
42
Registration Number
NCT01291472
Locations
🇧🇪

University Hospitals Leuven, Leuven, Belgium

Valproate Versus Ketorolac Versus Metoclopramide

Phase 4
Completed
Conditions
Acute Migraine
Interventions
First Posted Date
2010-12-29
Last Posted Date
2018-06-04
Lead Sponsor
Montefiore Medical Center
Target Recruit Count
330
Registration Number
NCT01267864
Locations
🇺🇸

Montefiore Medical Center, Bronx, New York, United States

Ketorolac in Postoperative Infants: Pharmacokinetics and Safety

Phase 3
Completed
Conditions
Postoperative Pain in Infants
Interventions
First Posted Date
2010-12-15
Last Posted Date
2013-06-13
Lead Sponsor
Seattle Children's Hospital
Target Recruit Count
77
Registration Number
NCT01260883
Locations
🇺🇸

Seattle Children's Hospital, Seattle, Washington, United States

Study of Whether 15 mg Dose of Ketorolac IV is as Effective as a 30 mg Dose.

Not Applicable
Conditions
Pain
Pain, Postoperative
Interventions
First Posted Date
2010-10-29
Last Posted Date
2010-10-29
Lead Sponsor
University of Calgary
Target Recruit Count
50
Registration Number
NCT01230463
Locations
🇨🇦

Foothills Medical Centre, Calgary, Alberta, Canada

Ketorolac Effects on Post-operative Pain and Bone Healing

Not Applicable
Terminated
Conditions
Bunion
Interventions
Drug: Placebo
First Posted Date
2010-05-31
Last Posted Date
2019-08-21
Lead Sponsor
Beth Israel Deaconess Medical Center
Target Recruit Count
18
Registration Number
NCT01133639
Locations
🇺🇸

Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

Efficacy of Multimodal Perioperative Analgesia With Periarticular Drug Injection in Total Knee Arthroplasty(TKA)

Not Applicable
Completed
Conditions
Osteoarthritis,Knee
Interventions
First Posted Date
2010-01-05
Last Posted Date
2013-11-08
Lead Sponsor
Towson Orthopaedic Associates
Target Recruit Count
160
Registration Number
NCT01042093

A Comparison of Post Phacoemulsification Aqueous Flare in Patients Using Ketorolac 0.45% 2 Times Daily (BID) and Bromfenac 0.09% 2 Times Daily (BID)

Phase 4
Completed
Conditions
Post Operative Anterior Chamber Inflammation (Flare)
Interventions
First Posted Date
2009-12-02
Last Posted Date
2011-08-26
Lead Sponsor
Bucci Laser Vision Institute
Target Recruit Count
50
Registration Number
NCT01023724
Locations
🇺🇸

Bucci Laser Vision Institute, Wilkes-Barre, Pennsylvania, United States

Safety and Efficacy Study of KAI-1678 to Treat Subjects With Postoperative Pain

Phase 2
Completed
Conditions
Pain, Postoperative
Interventions
First Posted Date
2009-11-18
Last Posted Date
2011-09-02
Lead Sponsor
KAI Pharmaceuticals
Target Recruit Count
90
Registration Number
NCT01015235
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