Nitazoxanide

Generic Name: Nitazoxanide

Brand Names: Alinia, Busulfex

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₉N_₃O_₅S

CAS Number: 55981-09-4

Unique Ingredient Identifier: SOA12P041N

Background: Nitazoxanide belongs to the class of drugs known as thiazolides. Nitazoxanide (NTZ) is a broad-spectrum anti-infective drug that markedly modulates the survival, growth, and proliferation of a range of extracellular and intracellular protozoa, helminths, anaerobic and microaerophilic bacteria, in addition to viruses. This drug is effective in the treatment of gastrointestinal infections including Cryptosporidium parvum or Giardia lamblia in healthy subjects. It is generally well tolerated. Nitazoxanide is a first-line, standard treatment for illness caused by C. parvum or G. lamblia infection in healthy (not immunosuppressed) adults and children and may also be considered in the treatment of illnesses caused by other protozoa or helminths . Recently, this drug has been studied as a broad-spectrum antiviral agent due to its ability to inhibit the replication of several RNA and DNA viruses .

Indication: 用于治疗隐孢子虫、贾第鞭毛虫、阿米巴原虫引起的原虫性腹泻。

Associated Conditions: Diarrhea caused by Cryptosporidium parvum, Diarrhea caused by Giardia lamblia

Associated Therapies: -

Clinical Trials

Efficacy and Safety of Nitazoxanide in Preventing Recurrence of Hepatic Encephalopathy

Phase 3

Recruiting

Conditions: Hepatic Encephalopathy

Interventions: Drug: Nitazoxanide
Drug: Rifaximin

First Posted Date: 2019-11-13

Last Posted Date: 2019-11-13

Lead Sponsor: Tanta University

Target Recruit Count: 60

Registration Number: NCT04161053

Locations: 🇪🇬
Sherief Abd-Elsalam, Tanta, Egypt

Study of Nitazoxanide Compared to Placebo in Subjects With HBeAG-Negative Chronic Hepatitis B

Phase 2

Completed

Conditions: Chronic Hepatitis B

Interventions: Drug: Placebo Oral Tablet
Drug: Nitazoxanide

First Posted Date: 2019-04-05

Last Posted Date: 2023-11-07

Lead Sponsor: Romark Laboratories L.C.

Target Recruit Count: 51

Registration Number: NCT03905655

Locations: 🇸🇬
National University Hospital, Singapore, Singapore

Efficacy and Safety of Nitazoxanide in the Treatment of Colds Due to Enterovirus/Rhinovirus Infection

Phase 3

Completed

Conditions: Rhinovirus
Enterovirus

Interventions: Drug: Nitazoxanide
Drug: Placebo

First Posted Date: 2018-07-30

Last Posted Date: 2022-04-14

Lead Sponsor: Romark Laboratories L.C.

Target Recruit Count: 1756

Registration Number: NCT03605862

Locations: 🇵🇷
Vanguard Study Site, San Juan, Puerto Rico

NNITS-Nitazoxanide for Norovirus in Transplant Patients Study

Phase 2

Completed

Conditions: Gastroenteritis Norovirus

Interventions: Other: Placebo
Drug: Nitazoxanide

First Posted Date: 2018-01-10

Last Posted Date: 2023-10-11

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 31

Registration Number: NCT03395405

Locations: 🇺🇸
Northwestern University - Comprehensive Transplant Center, Chicago, Illinois, United States
🇺🇸
Johns Hopkins Hospital - Medicine - Infectious Diseases, Baltimore, Maryland, United States
🇺🇸
University of Pittsburgh - Medicine - Infectious Diseases, Pittsburgh, Pennsylvania, United States

and more 9 locations