Salmeterol

Generic Name: Salmeterol

Brand Names: Advair, Airduo, Airduo Respiclick, Serevent, Serevent Diskus, Wixela

Drug Type: Small Molecule

Chemical Formula: C_₂₅H_₃₇NO_₄

CAS Number: 89365-50-4

Unique Ingredient Identifier: 2I4BC502BT

Background: Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD. It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, salbutamol. Salmeterol was first described in the literature in 1988. Salmeterol's structure is similar to salbutamol's with an aralkyloxy-alkyl substitution on the amine.

Salmeterol was granted FDA approval on 4 February 1994.

Indication: 用于哮喘（包括夜间哮喘和运动性哮喘）、喘息性支气管炎和可逆性气道阻塞。

Associated Conditions: Asthma, Chronic Obstructive Pulmonary Disease (COPD), Exercise-Induced Bronchospasm

Clinical Trials

A Comparison of the Effects of Tiotropium Inhalation qd and Salmeterol Inhalation Bid on Arterial Blood Gases.

Phase 3

Completed

Conditions: Pulmonary Disease, Chronic Obstructive

First Posted Date: 2006-01-11

Last Posted Date: 2013-11-05

Lead Sponsor: Boehringer Ingelheim

Target Recruit Count: 36

Registration Number: NCT00274534

Locations: 🇺🇸
Hunter Holmes McGuire Medical Center, Richmond, Virginia, United States
🇺🇸
Hines Veterans Administration Hospital, Hines, Illinois, United States

A Multiple Dose Comparison of Tiotropium Inhalation Capsules and Salmeterol Inhalation Aerosol.

Phase 3

Completed

Conditions: Pulmonary Disease, Chronic Obstructive

First Posted Date: 2006-01-11

Last Posted Date: 2023-12-01

Lead Sponsor: Boehringer Ingelheim

Target Recruit Count: 653

Registration Number: NCT00274560

Locations: 🇺🇸
Temple University School of Medicine, Philadelphia, Pennsylvania, United States
🇬🇷
University Hospital of Ioannina, Ioannina, Greece
🇺🇸
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States

and more 32 locations

Study In Asthma Control

Phase 4

Terminated

Conditions: Asthma

First Posted Date: 2006-01-09

Last Posted Date: 2018-03-21

Lead Sponsor: GlaxoSmithKline

Target Recruit Count: 680

Registration Number: NCT00273026

Locations: 🇨🇦
GSK Investigational Site, Québec, Canada

Clinical Evaluation Of GW815SF For Chronic Obstructive Pulmonary Disease (Chronic Bronchitis, Emphysema)

Phase 3

Completed

Conditions: Pulmonary Disease, Chronic Obstructive

First Posted Date: 2005-12-23

Last Posted Date: 2013-04-15

Lead Sponsor: GlaxoSmithKline

Target Recruit Count: 150

Registration Number: NCT00269126

Locations: GSK Investigational Site

Survival Of Subjects With Chronic Obstructive Pulmonary Disease (COPD)

Phase 3

Completed

Conditions: Pulmonary Disease, Chronic Obstructive

First Posted Date: 2005-12-22

Last Posted Date: 2017-01-20

Lead Sponsor: GlaxoSmithKline

Target Recruit Count: 6228

Registration Number: NCT00268216

Locations: GSK Investigational Site

DESOLO - SiT Peri-Launch: A Comparison of Symbicort Single Inhaler Therapy and Conventional Best Practice for the Treatment of Persistent Asthma in Adults

Phase 3

Completed

Conditions: Asthma

First Posted Date: 2005-11-15

Last Posted Date: 2009-03-17

Lead Sponsor: AstraZeneca

Target Recruit Count: 1600

Registration Number: NCT00252863

Locations: 🇩🇪
Research Site, Zwickau, Germany

Montelukast Compared With Placebo and Salmeterol in Exercise-Induced Bronchoconstriction (0476-316)

Phase 3

Completed

Conditions: Asthma, Exercise-Induced

First Posted Date: 2005-10-28

Last Posted Date: 2022-02-02

Lead Sponsor: Organon and Co

Target Recruit Count: 47

Registration Number: NCT00245570

Pilot Study Comparing Tiotropium (Spiriva) to Salmeterol (Serevent) Plus Fluticasone (Flixotide) in Chronic Obstructive Pulmonary Disease (COPD)

Phase 4

Completed

Conditions: Pulmonary Disease, Chronic Obstructive

First Posted Date: 2005-10-17

Last Posted Date: 2013-11-11

Lead Sponsor: Boehringer Ingelheim

Target Recruit Count: 107

Registration Number: NCT00239499

Locations: 🇿🇦
Boehringer Ingelheim Investigational Site, Welkom, South Africa
🇿🇦
Tijger Trial Centre, Bellville, South Africa
🇿🇦
Durban Lung Centre, Durban, South Africa

and more 5 locations