Ubiquinol

Generic Name: Ubiquinol

Drug Type: Small Molecule

Chemical Formula: C_₅₉H_₉₂O_₄

CAS Number: 992-78-9

Unique Ingredient Identifier: M9NL0C577Y

Background: Ubiquinol (CoQH2) is a reduced form of coenzyme Q10 (CoQ10) that acts as an active antioxidant that prevents the initiation and propagation of lipid peroxidation in biological membranes and human low-density lipoprotein (LDL). It plays an essential role in maintaining cellular defense against oxidative damage and also sustains the effects of vitamin E by regenerating the vitamin from the tocopheroxyl radical, but ubiquinol is not classified as a vitamin because it is synthesized by humans. There are varying concentrations of ubiquinol in foods, OTC products and dietary supplement products.

Clinical Trials

Ubiquinone vs. Ubiquinol Supplementation

Phase 2

Recruiting

Conditions: IVF

Interventions: Drug: Ubiquinone 200 Mg Oral Capsule
Drug: Ubiquinol 100 MG Oral Capsule

First Posted Date: 2024-08-15

Last Posted Date: 2025-04-10

Lead Sponsor: Trio Fertility

Target Recruit Count: 90

Registration Number: NCT06555575

Locations: 🇨🇦
Trio Fertility, Toronto, Ontario, Canada

Ubiquinol in Parkinson's Disease: Safety, Tolerability, and Effects Upon Oxidative Damage and Mitochondrial Biomarkers

Phase 2

Completed

Conditions: Parkinson Disease

Interventions: Dietary Supplement: Placebo
Drug: Ubiquinol

First Posted Date: 2017-02-23

Last Posted Date: 2017-05-23

Lead Sponsor: Weill Medical College of Cornell University

Target Recruit Count: 11

Registration Number: NCT03061513

Ubiquinol as a Metabolic Resuscitator in Post-Cardiac Arrest

Phase 2

Completed

Conditions: Cardiac Arrest

Interventions: Dietary Supplement: Ensure
Drug: Ubiquinol

First Posted Date: 2016-10-17

Last Posted Date: 2021-02-15

Lead Sponsor: Beth Israel Deaconess Medical Center

Target Recruit Count: 48

Registration Number: NCT02934555

Locations: 🇺🇸
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

Coenzyme Q10 Phase III Trial in Gulf War Illness

Phase 3

Completed

Conditions: Gulf War Illness
Chronic Fatigue
Ubiquinol
Coenzyme Q10

Interventions: Drug: Placebo
Drug: Ubiquinol

First Posted Date: 2016-08-12

Last Posted Date: 2023-02-15

Lead Sponsor: VA Office of Research and Development

Target Recruit Count: 100

Registration Number: NCT02865460

Locations: 🇺🇸
James J. Peters VA Medical Center, Bronx, NY, Bronx, New York, United States
🇺🇸
Miami VA Healthcare System, Miami, FL, Miami, Florida, United States
🇺🇸
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts, United States

and more 1 locations