Ondansetron
- Generic Name
- Ondansetron
- Brand Names
- Zofran, Zuplenz
- Drug Type
- Small Molecule
- Chemical Formula
- C18H19N3O
- CAS Number
- 99614-02-5
- Unique Ingredient Identifier
- 4AF302ESOS
- Background
A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
...
- Indication
In the adult patient population:
i) orally administered ondansetron tablets and orally disintegrating tablets (ODT) are indicated for:
- the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy, including high dose (ie. greater than or equal to 50 mg/m2) cisplatin therapy, and radiotherapy, and
...
- Associated Conditions
- Chemotherapy-Induced Nausea and Vomiting, Cholestatic pruritus, Post Operative Nausea and Vomiting (PONV), Radiation-Induced Nausea and Vomiting, Uremic Pruritus, Severe Hyperemesis gravidarum
- Associated Therapies
- -
Aprepitant and Fosaprepitant Time-on-Target PET (Positron Emission Tomography) Study (0869-183)
- First Posted Date
- 2010-04-28
- Last Posted Date
- 2015-02-25
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 16
- Registration Number
- NCT01111851
Rescue Emetic Therapy for Children Having Elective Surgery
- Conditions
- Interventions
- First Posted Date
- 2010-02-11
- Last Posted Date
- 2017-11-14
- Lead Sponsor
- Franklyn Cladis
- Registration Number
- NCT01067677
- Locations
- 🇺🇸
The Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States
Scottish and Newcastle Anti-emetic Pre-treatment for Paracetamol Poisoning Study (SNAP)
- First Posted Date
- 2010-01-15
- Last Posted Date
- 2013-07-31
- Lead Sponsor
- University of Edinburgh
- Target Recruit Count
- 222
- Registration Number
- NCT01050270
- Locations
- 🇬🇧
Aberdeen Royal Infirmary, Aberdeen, United Kingdom
🇬🇧Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
🇬🇧Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
Palonosetron Versus Ondansetron for the Prevention of Nausea and Vomiting
- Conditions
- Interventions
- First Posted Date
- 2009-12-14
- Last Posted Date
- 2012-08-07
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 150
- Registration Number
- NCT01031498
- Locations
- 🇺🇸
UT MD Anderson Cancer Center, Houston, Texas, United States
Effect of Dexamethasone Combined With Ondansetron on Postoperative Nausea and Vomiting in Patients With Patient-controlled Analgesia After Video-assisted Thoracoscopic Surgery
- First Posted Date
- 2009-11-04
- Last Posted Date
- 2016-12-30
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 123
- Registration Number
- NCT01007500
- Locations
- 🇰🇷
Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of
Functional Magnetic Resonance Imaging of Opioid Withdrawal in Healthy Human Volunteers
- First Posted Date
- 2009-11-03
- Last Posted Date
- 2017-11-17
- Lead Sponsor
- Stanford University
- Target Recruit Count
- 15
- Registration Number
- NCT01006707
- Locations
- 🇺🇸
Stanford University School of Medicine, Stanford, California, United States
Bioavailability Study of Anti Nausea Medication With and Without Food (EUR-1025)
- First Posted Date
- 2009-09-22
- Last Posted Date
- 2017-02-09
- Lead Sponsor
- Forest Laboratories
- Target Recruit Count
- 22
- Registration Number
- NCT00981487
Ramosetron Versus Ondansetron for Radiotherapy Induced Nausea and Vomiting
- Conditions
- Interventions
- First Posted Date
- 2009-09-03
- Last Posted Date
- 2011-02-28
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 172
- Registration Number
- NCT00971399
- Locations
- 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of
Effectiveness of Aprepitant in Addition to Ondansetron in the Prevention of Nausea and Vomiting Caused by Upper Abdominal Radiotherapy
- First Posted Date
- 2009-09-03
- Last Posted Date
- 2017-12-05
- Lead Sponsor
- University of Vermont
- Target Recruit Count
- 52
- Registration Number
- NCT00970905
- Locations
- 🇺🇸
Wake Forest Baptist Health, Winston-Salem, North Carolina, United States
🇺🇸Fletcher Allen Health Care, Burlington, Vermont, United States
🇺🇸Mayo Clinic Arizona, Scottsdale, Arizona, United States
Pilot Study to Assess Palonosetron Versus Ondansetron as Rescue Medication in Subjects That Develop Postoperative Nausea and Vomiting (PONV) in the Postanesthesia Care Unit (PACU)
- Conditions
- Interventions
- First Posted Date
- 2009-08-28
- Last Posted Date
- 2021-01-11
- Lead Sponsor
- Eisai Inc.
- Target Recruit Count
- 239
- Registration Number
- NCT00967499
- Locations
- 🇺🇸
Precision Trials, Phoenix, Arizona, United States
🇺🇸University of Miami, Miami, Florida, United States
🇺🇸University of Kansas Medical Center, Kansas City, Kansas, United States
Drug Development Updates
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