Ondansetron
- Generic Name
- Ondansetron
- Brand Names
- Zofran, Zuplenz
- Drug Type
- Small Molecule
- Chemical Formula
- C18H19N3O
- CAS Number
- 99614-02-5
- Unique Ingredient Identifier
- 4AF302ESOS
- Background
A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
...
- Indication
In the adult patient population:
i) orally administered ondansetron tablets and orally disintegrating tablets (ODT) are indicated for:
- the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy, including high dose (ie. greater than or equal to 50 mg/m2) cisplatin therapy, and radiotherapy, and
...
- Associated Conditions
- Chemotherapy-Induced Nausea and Vomiting, Cholestatic pruritus, Post Operative Nausea and Vomiting (PONV), Radiation-Induced Nausea and Vomiting, Uremic Pruritus, Severe Hyperemesis gravidarum
- Associated Therapies
- -
The Effect of iv Ondansetron on Reducing Hypotension Due to BCIS in Total Knee Prosthesis Surgery
- Conditions
- Interventions
- First Posted Date
- 2022-06-06
- Last Posted Date
- 2022-06-06
- Lead Sponsor
- Ataturk University
- Target Recruit Count
- 1
- Registration Number
- NCT05405608
- Locations
- 🇹🇷
Aysenur Dostbil, Yakutiye, Erzurum, Turkey
The Efficacy of Adjunctive Use of Ondansetron in Patients With Sepsis and Septic Shock
- First Posted Date
- 2022-06-02
- Last Posted Date
- 2023-03-15
- Lead Sponsor
- Noha Mansour
- Target Recruit Count
- 40
- Registration Number
- NCT05402553
- Locations
- 🇪🇬
Tanta University Hospitals, Tanta, Egypt
Ondansetron as a Strategy for Reducing Propofol Injection Pain in Pediatrics: a Randomized Controlled Trial
- First Posted Date
- 2022-05-18
- Last Posted Date
- 2024-01-11
- Lead Sponsor
- Emory University
- Target Recruit Count
- 120
- Registration Number
- NCT05378113
- Locations
- 🇺🇸
Children's Healthcare of Atlanta, Atlanta, Georgia, United States
Low Dose Olanzapine to the Prophylaxis of Nausea and Vomiting Induced by Chemotherapy in Children and Adolescents
- Conditions
- Interventions
- First Posted Date
- 2022-04-26
- Last Posted Date
- 2022-07-28
- Target Recruit Count
- 210
- Registration Number
- NCT05346731
- Locations
- 🇷🇺
Zhukov Nikolay, Moscow, Russian Federation
Comparison of Postoperative Anti-nausea and Vomiting Effect Between Glycopyrronium and Ondansetron
- Conditions
- Interventions
- First Posted Date
- 2022-03-03
- Last Posted Date
- 2023-02-24
- Target Recruit Count
- 480
- Registration Number
- NCT05265507
- Locations
- 🇨🇳
The Second Affiliated Hospital, Chongqing Medical University, Chongqing, Chongqing, China
Effect of Dexmedetomidine on Prevention of Postoperative Nausea and Vomiting in Children
- Conditions
- Interventions
- First Posted Date
- 2021-11-17
- Last Posted Date
- 2022-04-05
- Lead Sponsor
- Tanta University
- Target Recruit Count
- 4
- Registration Number
- NCT05124067
- Locations
- 🇸🇦
Sharurah Armed Forces Hospital, Sharurah, Najran, Saudi Arabia
Capsaicin Cream as an Adjunctive Therapy for Nausea and Vomiting of Pregnancy
- First Posted Date
- 2021-10-28
- Last Posted Date
- 2024-02-07
- Lead Sponsor
- Women and Infants Hospital of Rhode Island
- Target Recruit Count
- 30
- Registration Number
- NCT05098067
- Locations
- 🇺🇸
Women and Infants Hospital, Providence, Rhode Island, United States
Effects of Ondansetron, Metoclopramide and Granisetron on Perioperative Nausea and Vomiting in Patients Undergone Bariatric Surgery
- First Posted Date
- 2021-10-21
- Last Posted Date
- 2021-10-29
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Target Recruit Count
- 130
- Registration Number
- NCT05087615
- Locations
- 🇮🇷
Loghman Hakim Hospital, Tehran, Iran, Islamic Republic of
Ondansetron Versus Domperidone for Treating Vomiting in Acute Gastroenteritis in Children
- Conditions
- Interventions
- First Posted Date
- 2021-10-13
- Last Posted Date
- 2021-10-13
- Lead Sponsor
- Tehsil Headquarter Hospital
- Target Recruit Count
- 300
- Registration Number
- NCT05076461
- Locations
- 🇵🇰
Tehsil Headquarter Hospital, Liaquatpur, Punjab, Pakistan
Hyoscine Butyl-bromide Versus Ondansetron for Nausea and Vomiting During Cesarean Section Under Spinal Anesthesia
- Conditions
- Interventions
- First Posted Date
- 2021-03-05
- Last Posted Date
- 2023-03-16
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 165
- Registration Number
- NCT04785118
- Locations
- 🇪🇬
Assiut University hospital, Assiut, Egypt
Drug Development Updates
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