Estradiol
- Generic Name
- Estradiol
- Brand Names
- Activella 1/0.5 28 Day, Activelle, Amabelz 0.5/0.1 28 Day, Angeliq 0.25/0.5 28 Day, Bijuva, Climara, Climara Pro, Combipatch, Divigel, Dotti, Elestrin, Estalis, Estrace, Estradot, Estring, Estrogel, Etyqa 0.5/0.1 28 Day, Evamist, Imvexxy 4 Mcg Starter Pack, Lopreeza 1/0.5 28 Day, Lyllana, Menostar, Mimvey, Minivelle, Myfembree, Oesclim, Oriahnn 28 Day Kit, Prefest 30 Day, Vagifem, Vivelle, Yuvafem
- Drug Type
- Small Molecule
- Chemical Formula
- C18H24O2
- CAS Number
- 50-28-2
- Unique Ingredient Identifier
- 4TI98Z838E
- Background
Estradiol is a naturally occurring hormone circulating endogenously in females. It is commercially available in several hormone therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and hot flashes. Some available forms of estradiol include oral tablets, injections, vaginal rings, transdermal patches, sprays,...
- Indication
Estradiol is indicated in various preparations for the treatment of moderate to severe vasomotor symptoms and vulvar and vaginal atrophy due to menopause, for the treatment of hypoestrogenism due to hypogonadism, castration, or primary ovarian failure, and for the prevention of postmenopausal osteoporosis. It is also used for the treatment of breast cancer (...
- Associated Conditions
- Atrophic Vaginitis, Breast Cancer, Breast engorgement caused by Postpartum state, Heavy Menstrual Bleeding, Hypogonadism female, Kraurosis Vulvae, Metastatic Breast Cancer, Osteoporosis, Postmenopausal Osteoporosis, Premature Ovarian Failure (POF), Prostate Cancer, Severe Pain, Urogenital atrophy, Vasomotor Symptoms Associated With Menopause, Vulvo Vaginal Atrophy, Advanced androgen dependent Prostate cancer, Female castration, Hypoestrogenism
- Associated Therapies
- Contraception, Hormone Replacement Therapy, Palliative Treatment
Assessment of the Sensitivity of the Hypothalamic GnRH Pulse Generator to Estradiol and Progesterone Inhibition
- Conditions
- Interventions
- First Posted Date
- 2011-08-30
- Last Posted Date
- 2023-11-02
- Lead Sponsor
- University of Virginia
- Target Recruit Count
- 60
- Registration Number
- NCT01425541
- Locations
- 🇺🇸
Center for Research in Reproduction, Charlottesville, Virginia, United States
Estrogen Sensitivity and Ovulatory Dysfunction in Obesity
- Conditions
- Interventions
- First Posted Date
- 2011-06-27
- Last Posted Date
- 2015-04-20
- Lead Sponsor
- University of Colorado, Denver
- Target Recruit Count
- 30
- Registration Number
- NCT01381016
- Locations
- 🇺🇸
University of Colorado, Anschutz Medical Campus, Aurora, Colorado, United States
Antral Follicle Priming Prior to ICSI (Intracytoplasmic Sperm Injection) in Previously Diagnosed Low Responders
- Conditions
- Interventions
- First Posted Date
- 2011-03-08
- Last Posted Date
- 2014-02-28
- Lead Sponsor
- Instituto de Investigacion Sanitaria La Fe
- Target Recruit Count
- 66
- Registration Number
- NCT01310647
- Locations
- 🇪🇸
La Fe University Hospital. Department of Obstetrics and Gynecology, Valencia, Spain
Perimenopausal Estrogen Replacement Therapy Study
- First Posted Date
- 2011-03-04
- Last Posted Date
- 2017-08-22
- Lead Sponsor
- University of North Carolina, Chapel Hill
- Target Recruit Count
- 172
- Registration Number
- NCT01308814
- Locations
- 🇺🇸
University of North Carolina, Chapel Hill, North Carolina, United States
Optimizing Ovulation Induction in the Poor Responder
- Conditions
- Interventions
- First Posted Date
- 2010-09-13
- Last Posted Date
- 2012-11-21
- Lead Sponsor
- Duke University
- Registration Number
- NCT01200537
- Locations
- 🇺🇸
Duke Fertility Center, Durham, North Carolina, United States
Sex Hormones and Orthostatic Tolerance
- Conditions
- Interventions
- First Posted Date
- 2010-06-30
- Last Posted Date
- 2018-12-13
- Lead Sponsor
- Yale University
- Target Recruit Count
- 109
- Registration Number
- NCT01153581
- Locations
- 🇺🇸
John B. Pierce Laboratory, New Haven, Connecticut, United States
Effects of Estrogen and Hot Flashes on Mood in Postmenopausal Women
- First Posted Date
- 2010-05-20
- Last Posted Date
- 2017-10-20
- Lead Sponsor
- Massachusetts General Hospital
- Target Recruit Count
- 2
- Registration Number
- NCT01126801
- Locations
- 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
Estrogens Effect on Pain in Postmenopausal Women Suffering of Fibromyalgia
- First Posted Date
- 2010-03-16
- Last Posted Date
- 2010-03-16
- Lead Sponsor
- Ostergotland County Council, Sweden
- Target Recruit Count
- 29
- Registration Number
- NCT01087593
- Locations
- 🇸🇪
University hospital in Linköping, Linköping, Sweden
Estrogen for Triple Negative Breast Cancer
- First Posted Date
- 2010-03-10
- Last Posted Date
- 2019-12-09
- Lead Sponsor
- University of Wisconsin, Madison
- Target Recruit Count
- 17
- Registration Number
- NCT01083641
- Locations
- 🇺🇸
University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, United States
Hormone Replacement Therapy for Use in Postmenopausal Women for Relief of Hot Flushes and Urogenital Symptoms.
- Conditions
- Interventions
- First Posted Date
- 2010-02-18
- Last Posted Date
- 2013-04-22
- Lead Sponsor
- Warner Chilcott
- Target Recruit Count
- 249
- Registration Number
- NCT01070979
- Locations
- 🇺🇸
Warner Chilcott Investigational Site, Tacoma, Washington, United States
Drug Development Updates
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