Codeine

Generic Name: Codeine

Brand Names: Ascomp, Cheratussin, Cheratussin Dac, Codar Ar, Codar D, Codar Gf, Codeine Contin, Covan, Damylin With Codeine, Fioricet With Codeine, Histex Ac, Linctus Codeine Blanc, M-clear Wc, M-end PE, Mar-cof BP, Mar-cof Cg, Mersyndol, Ninjacof Xg, Pseudodine C, Robaxacet-8, Robaxisal, Triacin-C, Trianal C, Triatec, Triatec-30, Triatec-8, Tusnel C, Tuxarin, Tuzistra, Tylenol With Codeine

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₁NO_₃

CAS Number: 76-57-3

Unique Ingredient Identifier: UX6OWY2V7J

Background: The relief of pain (analgesia) is a primary goal for enhancing the quality of life of patients and for increasing the ability of patients to engage in day to day activities. Codeine, an opioid analgesic, was originally approved in the US in 1950 and is a drug used to decrease pain by increasing the threshold for pain without impairing consciousness or altering other sensory functions. Opiates such as codeine are derived from the poppy plant, Papaver somniferum (Papaveraceae).

Codeine is utilized as a central analgesic, sedative, hypnotic, antinociceptive, and antiperistaltic agent, and is also recommended in certain diseases with incessant coughing.

Indication: Codeine sulfate is a form of this drug that is commonly used. It is available in tablet form and indicated for the relief of mild to moderately severe pain, where the use of an opioid analgesic is appropriate .

The solution form is used by itself or combined in a syrup with other drugs and is used as a cough suppressant in adults aged 18 and above , .

Associated Conditions: Common Cold, Cough, Flu caused by Influenza, Mild pain, Pain, Severe Pain, Dry cough, Moderate Pain, Upper respiratory symptoms

Associated Therapies: Airway secretion clearance therapy

Clinical Trials

CHAO Tos: Codeina, HederA Helix, LevOdropropizina Para la TOS

Phase 4

Not yet recruiting

Conditions: Upper Resp Tract Infection

Interventions: Drug: Levodropropizine
Drug: Codeine
Drug: Ivy Leaves Cough Liquid
Drug: Placebo

First Posted Date: 2025-04-02

Last Posted Date: 2025-04-11

Lead Sponsor: Pontificia Universidad Catolica de Chile

Target Recruit Count: 184

Registration Number: NCT06907355

Locations: 🇨🇱
Pontificia Universidad Catolica de Chile, Santiago, Chile

Colonic Motor Patterns in Healthy Volunteers

Phase 4

Completed

Conditions: Opioid-Induced Constipation

Interventions: Drug: Naloxegol
Other: Placebo
Drug: codeine phosphate

First Posted Date: 2023-03-16

Last Posted Date: 2023-03-16

Lead Sponsor: Universitaire Ziekenhuizen KU Leuven

Target Recruit Count: 15

Registration Number: NCT05770960

Locations: 🇧🇪
UZ Leuven, Leuven, Vlaams-Brabant, Belgium

COMPARISON OF EFFICACY OF DIFFERENT DRUG COMBINATIONS IN ACUTE SCIATICA

Phase 3

Completed

Conditions: Sciatica Acute
Sciatica

Interventions: Drug: Lacosamide 50 MG Oral Tablet [Vimpat]
Drug: Diclofenac Sodium
Drug: Codeine Phosphate

First Posted Date: 2022-11-23

Last Posted Date: 2022-11-23

Lead Sponsor: Pakistan Institute of Medical Sciences

Target Recruit Count: 120

Registration Number: NCT05626140

Locations: 🇵🇰
Mehreen Mirza, Rawalpindi, Punjab, Pakistan

Fixed Combination of Dipirone and Codeine Compared to the Isolated Use of Dipyrone and Codeine in Controlling Pain After Pelvic-abdominal Surgery.

Phase 3

Completed

Conditions: Pain, Postoperative

Interventions: Drug: Fixed dose combination Dipyrone and Codeine
Drug: Dipyrone
Drug: Codeine

First Posted Date: 2020-11-23

Last Posted Date: 2024-06-27

Lead Sponsor: Brazilian Clinical Research Institute

Target Recruit Count: 491

Registration Number: NCT04641338

Locations: 🇧🇷
Santa Casa de Misericórdia de Votuporanga, Votuporanga, São Paulo, Brazil
🇧🇷
Hospital Universitário São Francisco na Providência de Deus, Bragança Paulista, São Paulo, Brazil
🇧🇷
Associação Hospital de Caridade Ijuí - Núcleo de Ensino e Pesquisa, Ijuí, Rio Grande Do Sul, Brazil