Overview
Vasopressin (arginine-vasopressin or antidiuretic hormone) is a nonapeptide primarily produced in the hypothalamus that exhibits diverse physiological functions related to diuresis, hemodynamic modulation, and behaviour. Vasopressin is very similar to oxytocin, differing in the third and eighth amino acids. Despite a wide variety of functions, exogenous vasopressin is primarily used to control blood pressure during systemic shock by increasing vasoconstriction and renal fluid reuptake by acting through V and V cellular receptors. The vasopressive effect of posterior pituitary gland extracts was noted in 1895, while vasopressin itself was not purified until 1951. It has been used for more than five decades for varying conditions, including variceal bleeding, diabetes insipidus, and, more recently, vasodilatory shock. It is currently marketed under the trademark VASOSTRICT® by PAR Pharmaceuticals.
Indication
1.诊断和治疗由于缺乏抗利尿激素而引起的尿崩症，也用于其他药物效果不佳的腹部肌肉松弛； 2.脑外科手术后或头颅创伤后多尿的初期治疗； 3.用于食管、胃肠道消化道疾病的急性大出血的辅助治疗。
Associated Conditions
- Acute Circulatory Failure
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2024/11/29 | Phase 4 | Recruiting | |||
2024/09/20 | Not Applicable | ENROLLING_BY_INVITATION | University of Electronic Science and Technology of China | ||
2024/08/09 | Phase 2 | Recruiting | |||
2024/06/24 | Phase 4 | Recruiting | |||
2024/06/18 | Phase 3 | Recruiting | |||
2024/05/23 | N/A | Not yet recruiting | |||
2024/05/21 | N/A | Recruiting | Hospital Universitario 12 de Octubre | ||
2024/05/17 | Phase 4 | Withdrawn | |||
2024/03/25 | Not Applicable | Recruiting | University of Electronic Science and Technology of China | ||
2024/03/25 | Not Applicable | Recruiting | University of Electronic Science and Technology of China |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| Medical Purchasing Solutions, LLC | 71872-7306 | INTRAVENOUS | 20 [USP'U] in 1 mL | 11/2/2023 | |
| Medical Purchasing Solutions, LLC | 71872-7264 | INTRAVENOUS | 20 [USP'U] in 1 mL | 5/3/2023 | |
| American Regent, Inc. | 0517-1030 | INTRAVENOUS | 20 [USP'U] in 1 mL | 1/1/2023 | |
| Eagle Pharmaceuticals, Inc. | 42367-570 | PARENTERAL | 20 U in 1 mL | 3/9/2023 | |
| American Regent, Inc. | 0517-1020 | INTRAVENOUS | 20 [USP'U] in 1 mL | 1/1/2023 | |
| Medical Purchasin Solutions, LLC | 71872-7014 | INTRAVENOUS | 20 [USP'U] in 1 mL | 6/1/2023 | |
| Par Pharmaceutical, Inc. | 42023-220 | INTRAVENOUS | 0.6 [USP'U] in 1 mL | 11/16/2023 | |
| Par Pharmaceutical, Inc. | 42023-164 | INTRAVENOUS | 20 [USP'U] in 1 mL | 11/16/2023 | |
| Gland Pharma Limited | 68083-520 | INTRAVENOUS | 20 [USP'U] in 1 mL | 2/14/2024 | |
| Fresenius Kabi USA, LLC | 63323-930 | INTRAVENOUS | 20 [USP'U] in 1 mL | 7/1/2022 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| VASOPRESSIN INJECTION USP 20 u/ml | SIN08350P | INJECTION | 20 u/ml | 9/19/1995 |
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| No TGA approvals found for this drug. | |||||
Health Canada Drug Approvals
Approved Product | Company | DIN | Dosage Form | Strength | Market Date |
|---|---|---|---|---|---|
| VASOPRESSIN INJECTION, USP | fresenius kabi canada ltd | 02139502 | Solution - Subcutaneous
,
Intramuscular | 20 UNIT / ML | 8/14/1996 |
| VASOPRESSIN INJ 20UNIT/ML USP | lyphomed, division of fujisawa canada inc. | 01944800 | Liquid - Subcutaneous
,
Intramuscular | 20 UNIT / ML | 12/31/1992 |
| VASOPRESSIN INJ 20UNIT/ML USP | Ferring Inc | 00693820 | Liquid - Nasal
,
Intramuscular
,
Subcutaneous | 20 UNIT / ML | 12/31/1988 |
| PITRESSIN INJ 10 UNIT/0.5ML | parke-davis division, warner-lambert canada inc. | 00222577 | Liquid - Subcutaneous
,
Intramuscular | 10 UNIT / .5 ML | 12/31/1971 |
| VASOPRESSIN INJECTION USP | 02247938 | Solution - Intramuscular
,
Subcutaneous | 20 UNIT / ML | 12/10/2003 |
CIMA AEMPS Drug Approvals
Approved Product | Company | Registration Number | Pharmaceutical Form | Prescription Type | Status |
|---|---|---|---|---|---|
| No CIMA AEMPS (Spain) approvals found for this drug. | |||||
Philippines FDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Philippines FDA approvals found for this drug. | |||||
Saudi SFDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Saudi SFDA approvals found for this drug. | |||||
Malaysia NPRA Drug Approvals
Approved Product | Company | Registration Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Malaysia NPRA approvals found for this drug. | |||||
UK EMC Drug Information
Medicine Name | MA Holder | MA Number | Pharmaceutical Form | Active Ingredient | Authorization Date |
|---|---|---|---|---|---|
| No UK EMC drug information found for this drug. | |||||
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