Bicalutamide

Generic Name
Bicalutamide
Brand Names
Casodex
Drug Type
Small Molecule
Chemical Formula
C18H14F4N2O4S
CAS Number
90357-06-5
Unique Ingredient Identifier
A0Z3NAU9DP
Background

Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor.

Indication

Bicalutamide is indicated in combination with a luteinizing hormone-releasing hormone (LHRH) agonist for the treatment of Stage D2 metastatic carcinoma of the prostate.

Associated Conditions
Metastatic stage D2 Prostatic carcinoma
Associated Therapies
-

Hormone Therapy Plus Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Prostate Cancer

First Posted Date
2003-01-27
Last Posted Date
2020-10-22
Lead Sponsor
Radiation Therapy Oncology Group
Target Recruit Count
397
Registration Number
NCT00004054
Locations
🇺🇸

Lutheran General Cancer Care Center, Park Ridge, Illinois, United States

🇺🇸

Greater Baltimore Medical Center and Cancer Center, Baltimore, Maryland, United States

🇺🇸

Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia, Pennsylvania, United States

and more 51 locations

S9921, Hormone Therapy With or Without Mitoxantrone and Prednisone in Patients Who Have Undergone Radical Prostatectomy for Prostate Cancer

First Posted Date
2003-01-27
Last Posted Date
2022-12-30
Lead Sponsor
SWOG Cancer Research Network
Target Recruit Count
983
Registration Number
NCT00004124
Locations
🇺🇸

Cancer Care Center at Advocate Lutheran Hospital, Park Ridge, Illinois, United States

🇺🇸

Alta Bates Comprehensive Cancer Center, Berkeley, California, United States

🇺🇸

Bismarck Cancer Center, Bismarck, North Dakota, United States

and more 228 locations

Adjuvant Radiation Therapy Plus Hormone Therapy Compared With Radiation Therapy Alone in Treating Patients With Stage II or Stage III Prostate Cancer

First Posted Date
2003-01-27
Last Posted Date
2020-10-22
Lead Sponsor
Radiation Therapy Oncology Group
Target Recruit Count
67
Registration Number
NCT00023829
Locations
🇨🇦

Toronto Sunnybrook Regional Cancer Centre, Toronto, Ontario, Canada

Hormone Therapy in Treating Patients With Rising PSA Levels Following Radiation Therapy for Prostate Cancer

First Posted Date
2003-01-27
Last Posted Date
2021-06-23
Lead Sponsor
NCIC Clinical Trials Group
Target Recruit Count
1386
Registration Number
NCT00003653
Locations
🇨🇦

BCCA - Cancer Centre for the Southern Interior, Kelowna, British Columbia, Canada

🇨🇦

BCCA - Fraser Valley Cancer Centre, Surrey, British Columbia, Canada

🇨🇦

Clinical Research Unit at Vancouver Coastal, Vancouver, British Columbia, Canada

and more 26 locations

Hormone Therapy and Radiation Therapy in Treating Patients With Prostate Cancer

First Posted Date
2003-01-27
Last Posted Date
2022-06-15
Lead Sponsor
Radiation Therapy Oncology Group
Target Recruit Count
1579
Registration Number
NCT00005044
Locations
🇺🇸

Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States

🇺🇸

Veterans Affairs Medical Center - Philadelphia, Philadelphia, Pennsylvania, United States

🇺🇸

Mercy Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States

and more 258 locations

Antineoplaston Therapy in Treating Patients With Stage III or Stage IV Prostate Cancer

First Posted Date
2003-01-27
Last Posted Date
2013-07-10
Lead Sponsor
Burzynski Research Institute
Registration Number
NCT00003517
Locations
🇺🇸

Burzynski Clinic, Houston, Texas, United States

SWOG-9346, Hormone Therapy in Treating Men With Stage IV Prostate Cancer

First Posted Date
2003-01-27
Last Posted Date
2017-04-17
Lead Sponsor
SWOG Cancer Research Network
Target Recruit Count
3040
Registration Number
NCT00002651
Locations
🇨🇦

Saskatoon Cancer Centre at the University of Saskatchewan, Saskatoon, Saskatchewan, Canada

🇨🇦

McGill Cancer Centre at McGill University, Montreal, Quebec, Canada

🇨🇦

Cancer Centre of Southeastern Ontario at Kingston General Hospital, Kingston, Ontario, Canada

and more 11 locations

Radiation Therapy With or Without Bicalutamide for Recurrent pT3N0 Prostate Cancer After Radical Prostatectomy

First Posted Date
2003-01-27
Last Posted Date
2022-06-15
Lead Sponsor
Radiation Therapy Oncology Group
Target Recruit Count
840
Registration Number
NCT00002874
Locations
🇺🇸

USC/Norris Comprehensive Cancer Center and Hospital, Los Angeles, California, United States

🇺🇸

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States

🇺🇸

Albert Einstein Cancer Center, Philadelphia, Pennsylvania, United States

and more 237 locations

Radiation Therapy With or Without Bicalutamide and Goserelin in Treating Patients With Prostate Cancer

Phase 3
Completed
Conditions
First Posted Date
2003-01-27
Last Posted Date
2016-09-02
Lead Sponsor
European Organisation for Research and Treatment of Cancer - EORTC
Target Recruit Count
819
Registration Number
NCT00021450
Locations
🇫🇷

Centre Hospitalier Regional de Besancon - Hopital Jean Minjoz, Besancon, France

🇮🇪

Saint Luke's Hospital, Dublin, Ireland

🇨🇾

Bank Of Cyprus Oncology Centre, Nicosia, Cyprus

and more 17 locations
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