Lactulose
- Generic Name
- Lactulose
- Brand Names
- Constulose, Enulose, Generlac, Kristalose
- Drug Type
- Small Molecule
- Chemical Formula
- C12H22O11
- CAS Number
- 4618-18-2
- Unique Ingredient Identifier
- 9XH2P2N8EP
- Background
Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE). Despite being first synthesized in 1929, investigations regarding its possible use as a laxative for the treatment of chronic constipa...
- Indication
Lactulose is indicated for use as a laxative in the treatment of chronic constipation in adults and geriatric patients.
...
- Associated Conditions
- Constipation, Hepatic Encephalopathy (HE)
- Associated Therapies
- -
A Trial to Improve Quality of Life in People With Cirrhosis
- First Posted Date
- 2021-09-30
- Last Posted Date
- 2023-11-21
- Lead Sponsor
- University of Michigan
- Target Recruit Count
- 56
- Registration Number
- NCT05061992
- Locations
- 🇺🇸
University of Michigan, Ann Arbor, Michigan, United States
Comparison of Oral Lactulose Versus Polyethylene Glycol for Bowel Preparation
- First Posted Date
- 2021-03-11
- Last Posted Date
- 2021-03-11
- Lead Sponsor
- First People's Hospital of Hangzhou
- Target Recruit Count
- 800
- Registration Number
- NCT04794049
Efficacy and Safety of E.Coli Nissle 1917 in Patients With Mild (Stage 1-2) or Minimal Hepatic Encephalopathy
- Conditions
- Interventions
- First Posted Date
- 2021-03-08
- Last Posted Date
- 2021-03-08
- Lead Sponsor
- Bogomolets National Medical University
- Target Recruit Count
- 42
- Registration Number
- NCT04787276
Polyethylene Glycol Versus Lactulose on Hepatic Encephalopathy in Patients With Cirrhosis;(PEGHE Trial)
- Conditions
- Interventions
- First Posted Date
- 2020-06-18
- Last Posted Date
- 2023-04-19
- Lead Sponsor
- Aga Khan University
- Target Recruit Count
- 102
- Registration Number
- NCT04436601
- Locations
- 🇵🇰
Aga Khan University, Karachi, Sindh, Pakistan
Intravenous Branched Chain Amino Acids for Hepatic Encephalopathy in ACLF
- Conditions
- Interventions
- First Posted Date
- 2020-01-23
- Last Posted Date
- 2022-08-16
- Target Recruit Count
- 70
- Registration Number
- NCT04238416
- Locations
- 🇮🇳
PGIMER, Chandigarh, India
PEG3350 in ACLF With Hepatic Encephalopathy
- Conditions
- Interventions
- First Posted Date
- 2019-06-17
- Last Posted Date
- 2019-06-17
- Target Recruit Count
- 60
- Registration Number
- NCT03987893
- Locations
- 🇮🇳
Postgraduate Institute of Medical Education and Research, Chandigarh, India
Efficacy and Safety of PEG 3350 for Treatment of Chronic Constipation
- First Posted Date
- 2019-05-21
- Last Posted Date
- 2020-10-20
- Lead Sponsor
- Fakultas Kedokteran Universitas Indonesia
- Target Recruit Count
- 184
- Registration Number
- NCT03957668
- Locations
- 🇮🇩
Puskesmas Kelurahan Paseban, Jakarta, DKI Jakarta, Indonesia
🇮🇩Puskesmas Kelurahan Petamburan, Jakarta, DKI Jakarta, Indonesia
🇮🇩RSUPN dr. Cipto Mangunkusumo (Cipto Mangunkusumo Hospital), Jakarta, DKI Jakarta, Indonesia
Mode of Action of Ondansetron, a 5-HT Receptor 3 Antagonist, in Lactulose Induced Diarrhoea
- Conditions
- Interventions
- First Posted Date
- 2019-02-07
- Last Posted Date
- 2019-11-27
- Lead Sponsor
- University of Nottingham
- Target Recruit Count
- 16
- Registration Number
- NCT03833999
- Locations
- 🇬🇧
University of Nottingham, Nottingham, Nottinghamshire, United Kingdom
To Assess Efficacy of Nutritional Therapy in Secondary Prophylaxis of Hepatic Encephalopathy Versus Lactulose in Patients With Liver Cirrhosis.
- Conditions
- Interventions
- First Posted Date
- 2017-05-19
- Last Posted Date
- 2018-12-11
- Lead Sponsor
- Institute of Liver and Biliary Sciences, India
- Registration Number
- NCT03161106
- Locations
- 🇮🇳
Institute of Liver and Biliary Sciences, New Delhi, Delhi, India
High Volume Plasmapheresis for Refractory Hepatic Encephalopathy in Liver Intensive Care Unit.
- Conditions
- Interventions
- First Posted Date
- 2017-04-14
- Last Posted Date
- 2019-11-04
- Lead Sponsor
- Institute of Liver and Biliary Sciences, India
- Registration Number
- NCT03115697
- Locations
- 🇮🇳
Institute of Liver and Biliary Sciences, New Delhi, Delhi, India
Drug Development Updates
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