Bisacodyl

Generic Name: Bisacodyl

Brand Names: Alophen Reformulated Jan 2008, Bi-peglyte, Bisac-evac, Carters Little Pills, Dulcolax, Fleet Mineral Oil, Gavilyte-H and Bisacodyl

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₁₉NO_₄

CAS Number: 603-50-9

Unique Ingredient Identifier: 10X0709Y6I

Background: Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation. Both bisacodyl and picosulfate are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).

Bisacodyl was patented on 25 September 1956 but has been used as a laxative since 1952.

Indication: Bisacodyl is indicated to relieve occasional constipation and irregularity.

Associated Conditions: Bowel movement irregularity, Constipation, Occasional Constipation

Associated Therapies: Bowel preparation therapy

Clinical Trials

A Study to Evaluate the Drug Levels of BMS-986166 in Healthy Male Participants

Phase 1

Completed

Conditions: Healthy Participants

Interventions: Drug: BMS-986166
Drug: Bisacodyl

First Posted Date: 2022-06-08

Last Posted Date: 2023-03-22

Lead Sponsor: Bristol-Myers Squibb

Target Recruit Count: 7

Registration Number: NCT05409157

Locations: 🇺🇸
Local Institution - 0001, Madison, Wisconsin, United States

Lubiprostone for Functional Constipation in the Under 18 Years Patients

Phase 3

Completed

Conditions: Clinical Efficacy
Treatment Efficacy
Drug Side Effect

Interventions: Drug: Lubiprostone Pill
Drug: Lactulose Oral Liquid Product
Drug: Bisacodyl 5 MG
Drug: Sodium Picosulfate

First Posted Date: 2021-12-03

Last Posted Date: 2022-11-15

Lead Sponsor: Alexandria University

Target Recruit Count: 274

Registration Number: NCT05144295

Locations: 🇪🇬
Faculty of Medicine, Alexandria, Egypt
🇪🇬
Alexandria Main University Hospital, Alexandria, Egypt

Unrestricted Diet for Screening Colonoscopy

Not Applicable

Completed

Conditions: Bowel Cleansing
Bowel Cancer
Colonoscopy

Interventions: Other: 1-day low residue diet
Other: Unrestricted diet before colonoscopy
Drug: Bisacodyl 5 MG

First Posted Date: 2021-09-02

Last Posted Date: 2022-12-07

Lead Sponsor: Parc Taulí Hospital Universitari

Target Recruit Count: 553

Registration Number: NCT05032794

Locations: 🇪🇸
Consorci Sanitari de Terrassa, Terrassa, Spain
🇪🇸
Hospital de Mataró. Consorci Sanitari del Maresme., Mataró, Barcelona, Spain
🇪🇸
Hospital Universitario de Canarias, San Cristóbal de la Laguna, Santa Cruz De Tenerife, Spain

and more 2 locations

RELISTOR's Effects on Opioid-Induced Constipation

Withdrawn

Conditions: OIC

Interventions: Drug: Docusate Calcium
Drug: Relistor Injectable Product
Drug: Bisacodyl
Drug: Milk of magnesia
Drug: Magnesium citrate
Drug: Senna
Drug: Enema

First Posted Date: 2021-06-18

Last Posted Date: 2022-05-03

Lead Sponsor: Methodist Health System

Registration Number: NCT04930237

Locations: 🇺🇸
Methodist Moody Brain and Spine Institute, Methodist Dallas Medical Center, Dallas, Texas, United States

Defecation Patterns in Constipated Patients

Not Applicable

Suspended

Conditions: Constipation by Outlet Obstruction

Interventions: Drug: Atropin
Drug: Bisacodyl

First Posted Date: 2021-05-26

Last Posted Date: 2025-01-30

Lead Sponsor: University of California, San Diego

Target Recruit Count: 130

Registration Number: NCT04903470

Locations: 🇺🇸
University of California San Diego, La Jolla, California, United States

MRI Assessment of Mode of Action of Bisacodyl, Single Dose

Phase 4

Completed

Conditions: Constipation

Interventions: Drug: Bisacodyl 5 milligram
Drug: Placebo oral tablet

First Posted Date: 2019-10-21

Last Posted Date: 2024-07-03

Lead Sponsor: University of Nottingham

Target Recruit Count: 12

Registration Number: NCT04132661

Locations: 🇬🇧
University of Nottingham, Nottingham, Nottinghamshire, United Kingdom

MRI Assessment of Mode of Action of Bisacodyl, Multiple Doses

Phase 4

Completed

Conditions: Constipation

Interventions: Drug: Placebo oral tablet
Drug: Bisacodyl 5 milligram

First Posted Date: 2019-10-17

Last Posted Date: 2024-07-03

Lead Sponsor: University of Nottingham

Target Recruit Count: 12

Registration Number: NCT04129788

Locations: 🇬🇧
University of Nottingham, Nottingham, Nottinghamshire, United Kingdom

Effectiveness of Bisacodyl Suppository Agent for Dose Reduction of Low Dose PEG

Not Applicable

Completed

Conditions: Bowel Preparation

Interventions: Drug: 2L PEG-Asc
Drug: Bisacodyl 10Mg Suppository
Drug: 1L PEG-Asc

First Posted Date: 2019-02-21

Last Posted Date: 2019-02-21

Lead Sponsor: Samsung Medical Center

Target Recruit Count: 168

Registration Number: NCT03849196

Locations: 🇰🇷
Samsung Medical Center, Seoul, Korea, Republic of

Effect of PEG, Bisacodyl and Prucalopride on Colonic Motility in Healthy Subjects

Phase 4

Completed

Conditions: Chronic Constipation

Interventions: Drug: Prucalopride
Drug: polyethylene glycol
Drug: Bisacodyl

First Posted Date: 2017-09-12

Last Posted Date: 2017-09-12

Lead Sponsor: University Hospital, Gasthuisberg

Target Recruit Count: 10

Registration Number: NCT03279341

Locations: 🇧🇪
TARGID, Leuven, Belgium

Reclassifying Constipation Using Imaging and Manometry

Not Applicable

Conditions: Irritable Bowel Syndrome Characterized by Constipation
Constipation - Functional

Interventions: Procedure: MRI Motility
Procedure: High Resolution Manometry
Drug: Bisacodyl
Drug: Hyoscine butylbromide

First Posted Date: 2017-07-21

Last Posted Date: 2020-07-07

Lead Sponsor: University of Nottingham

Target Recruit Count: 120

Registration Number: NCT03226145

Locations: 🇬🇧
Queen Mary University of London, London, United Kingdom
🇬🇧
University College London, London, United Kingdom
🇬🇧
University of Nottingham, Nottingham, Notts, United Kingdom

Drug Development Updates

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