Prucalopride
- Generic Name
- Prucalopride
- Brand Names
- Motegrity, Resolor, Resotran
- Drug Type
- Small Molecule
- Chemical Formula
- C18H26ClN3O3
- CAS Number
- 179474-81-8
- Unique Ingredient Identifier
- 0A09IUW5TP
- Background
Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride was developed by Shire Development LLC and approved for use in Europe in 2009, in Canada on December 7, 2011 and by the FDA on December 17, 2018.
- Indication
Prucalopride is indicated for the treatment of chronic idiopathic constipation (CIC) in adults.
CIC is one of the most common chronic functional gastrointestinal disorders worldwide. The diagnosis of this agent is very hard and it can be confirmed if the patient experience at least two of the following:
-Straining during more than 25% of the bowel movements.
-Lumpy or hard stools in 25% of the bowel movements.
-Sensation of incomplete evacuation in more than 25% of all bowel movements.
-Sensation of anorectal blockage or obstruction in more than 25% of the bowel movements.
-Manual maneuvers required in more than 25% of the bowel movements.
-Fewer than 3 bowel movements per week.
- Associated Conditions
- Opioid Induced Constipation (OIC), Chronic idiopathic constipation (CIC), Refractory Chronic idiopathic constipation
Impact of Varying Doses of Prucalopride on Improving Gut Function Recovery After Elective Colorectal Surgery
- Conditions
- Post-Op Complication
- Interventions
- First Posted Date
- 2025-02-10
- Last Posted Date
- 2025-03-19
- Lead Sponsor
- Future University in Egypt
- Target Recruit Count
- 180
- Registration Number
- NCT06816407
- Locations
- 🇪🇬
Matareya Hospital, Cairo, Egypt
Prucalopride for Cognitive Functioning in Schizophrenia
- First Posted Date
- 2024-06-25
- Last Posted Date
- 2025-03-18
- Lead Sponsor
- University of Pittsburgh
- Target Recruit Count
- 34
- Registration Number
- NCT06474286
- Locations
- 🇮🇳
K S Hegde Medical Academy,, Mangalore, Karnataka, India
Bowel Preparation Regimen for Colon Capsule Endoscopy Procedure
- Conditions
- Colon PolypColon CancerInflammatory Bowel DiseasesGastrointestinal Bleed
- Interventions
- Drug: polyethylene glycol + ascorbic acidDrug: magnesiumoxid + sodium picosulfate
- First Posted Date
- 2023-02-13
- Last Posted Date
- 2024-02-28
- Lead Sponsor
- Region Skane
- Target Recruit Count
- 147
- Registration Number
- NCT05726097
- Locations
- 🇸🇪
Skåne University Hospital, Malmö, Sweden
The Effect of Prucalopride on Gastric Emptying in Intensive Care Unit Patients
- Conditions
- Enteral Feeding Intolerance
- Interventions
- First Posted Date
- 2022-08-11
- Last Posted Date
- 2024-04-12
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 70
- Registration Number
- NCT05496179
- Locations
- 🇪🇬
Kasr Al Ainy Hospital, Cairo, Egypt
Gastrointestinal Dysmotility on Aspiration Risk
- Conditions
- Esophageal Motility DisordersGastric Motor DysfunctionGastro Esophageal RefluxAspiration Pneumonia
- Interventions
- First Posted Date
- 2022-07-13
- Last Posted Date
- 2022-07-13
- Lead Sponsor
- Boston Children's Hospital
- Target Recruit Count
- 120
- Registration Number
- NCT05455359
Preventing Gastric Glitch With Prucalopride and Buspirone: N-of-1 Clinical Trial
- First Posted Date
- 2022-05-17
- Last Posted Date
- 2022-05-17
- Lead Sponsor
- Universidade de Passo Fundo
- Target Recruit Count
- 1
- Registration Number
- NCT05377619
- Locations
- 🇧🇷
University of Passo Fundo, Passo Fundo, RS, Brazil
Prucalopride and Cognition in Recovered Depression
- Conditions
- Depression in Remission
- Interventions
- Drug: Placebo
- First Posted Date
- 2022-02-02
- Last Posted Date
- 2024-02-09
- Lead Sponsor
- University of Oxford
- Target Recruit Count
- 50
- Registration Number
- NCT05220228
- Locations
- 🇬🇧
Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, Oxfordshire, United Kingdom
Prucalopride for Postoperative Ileus in Patients Undergoing Robot-assisted Laparoscopic Radical Cystectomy
- First Posted Date
- 2021-08-12
- Last Posted Date
- 2021-08-12
- Lead Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
- Target Recruit Count
- 160
- Registration Number
- NCT05001763
Study of Comparative Effectiveness of Prucalopride and Lubiprostone in Constipation Predominant Irritable Bowel Syndrome
- First Posted Date
- 2021-08-02
- Last Posted Date
- 2021-08-30
- Lead Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
- Target Recruit Count
- 140
- Registration Number
- NCT04985669
- Locations
- 🇧🇩
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
A Study of Prucalopride For Functional Constipation in Children and Teenagers
- First Posted Date
- 2021-02-18
- Last Posted Date
- 2024-06-06
- Lead Sponsor
- Takeda
- Target Recruit Count
- 175
- Registration Number
- NCT04759833
- Locations
- 🇺🇸
Pediatric & Adult Research Center, Kissimmee, Florida, United States
🇺🇸The University of Chicago Medical Center, Chicago, Illinois, United States
🇺🇸Cleveland Clinic, Cleveland, Ohio, United States
Drug Development Updates
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