Prucalopride
- Generic Name
- Prucalopride
- Brand Names
- Motegrity, Resolor, Resotran
- Drug Type
- Small Molecule
- Chemical Formula
- C18H26ClN3O3
- CAS Number
- 179474-81-8
- Unique Ingredient Identifier
- 0A09IUW5TP
- Background
Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride...
- Indication
Prucalopride is indicated for the treatment of chronic idiopathic constipation (CIC) in adults.
CIC is one of the most common chronic functional gastrointestinal disorders worldwide. The diagnosis of this agent is very hard and it can be confirmed if the patient experience at least two of the following:
...
- Associated Conditions
- Opioid Induced Constipation (OIC), Chronic idiopathic constipation (CIC), Refractory Chronic idiopathic constipation
- Associated Therapies
- -
Bowel Preparation Regimen for Colon Capsule Endoscopy Procedure
- First Posted Date
- 2023-02-13
- Last Posted Date
- 2024-02-28
- Lead Sponsor
- Region Skane
- Target Recruit Count
- 147
- Registration Number
- NCT05726097
- Locations
- 🇸🇪
Skåne University Hospital, Malmö, Sweden
The Effect of Prucalopride on Gastric Emptying in Intensive Care Unit Patients
- Conditions
- Interventions
- First Posted Date
- 2022-08-11
- Last Posted Date
- 2024-04-12
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 70
- Registration Number
- NCT05496179
- Locations
- 🇪🇬
Kasr Al Ainy Hospital, Cairo, Egypt
Gastrointestinal Dysmotility on Aspiration Risk
- Conditions
- Interventions
- First Posted Date
- 2022-07-13
- Last Posted Date
- 2022-07-13
- Lead Sponsor
- Boston Children's Hospital
- Target Recruit Count
- 120
- Registration Number
- NCT05455359
Preventing Gastric Glitch With Prucalopride and Buspirone: N-of-1 Clinical Trial
- First Posted Date
- 2022-05-17
- Last Posted Date
- 2022-05-17
- Lead Sponsor
- Universidade de Passo Fundo
- Target Recruit Count
- 1
- Registration Number
- NCT05377619
- Locations
- 🇧🇷
University of Passo Fundo, Passo Fundo, RS, Brazil
Prucalopride and Cognition in Recovered Depression
- Conditions
- Interventions
- First Posted Date
- 2022-02-02
- Last Posted Date
- 2024-02-09
- Lead Sponsor
- University of Oxford
- Target Recruit Count
- 50
- Registration Number
- NCT05220228
- Locations
- 🇬🇧
Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, Oxfordshire, United Kingdom
Prucalopride for Postoperative Ileus in Patients Undergoing Robot-assisted Laparoscopic Radical Cystectomy
- First Posted Date
- 2021-08-12
- Last Posted Date
- 2021-08-12
- Target Recruit Count
- 160
- Registration Number
- NCT05001763
A Study of Prucalopride For Functional Constipation in Children and Teenagers
- First Posted Date
- 2021-02-18
- Last Posted Date
- 2024-06-06
- Lead Sponsor
- Takeda
- Target Recruit Count
- 175
- Registration Number
- NCT04759833
- Locations
- 🇺🇸
Pediatric & Adult Research Center, Kissimmee, Florida, United States
🇺🇸The University of Chicago Medical Center, Chicago, Illinois, United States
🇺🇸Cleveland Clinic, Cleveland, Ohio, United States
The Effect of Prucalopride (Resolor®) on Gastric Motor Function and Gastric Sensitivity
- Conditions
- Interventions
- First Posted Date
- 2020-06-12
- Last Posted Date
- 2021-10-26
- Lead Sponsor
- Universitaire Ziekenhuizen KU Leuven
- Target Recruit Count
- 17
- Registration Number
- NCT04429802
Efficacy of PRUcalopride in Critically Ill Patients With Paralytic ILeus
- First Posted Date
- 2019-12-09
- Last Posted Date
- 2020-02-06
- Lead Sponsor
- Prince of Songkla University
- Target Recruit Count
- 62
- Registration Number
- NCT04190173
- Locations
- 🇹🇭
Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand
Effects of Acute Prucalopride Administration in Healthy Volunteers
- Conditions
- Interventions
- First Posted Date
- 2019-03-05
- Last Posted Date
- 2019-03-05
- Lead Sponsor
- University of Oxford
- Target Recruit Count
- 41
- Registration Number
- NCT03863366
- Locations
- 🇬🇧
University of Oxford, Oxford, United Kingdom
Drug Development Updates
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