Prucalopride

Generic Name
Prucalopride
Brand Names
Motegrity, Resolor, Resotran
Drug Type
Small Molecule
Chemical Formula
C18H26ClN3O3
CAS Number
179474-81-8
Unique Ingredient Identifier
0A09IUW5TP
Background

Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride...

Indication

Prucalopride is indicated for the treatment of chronic idiopathic constipation (CIC) in adults.

CIC is one of the most common chronic functional gastrointestinal disorders worldwide. The diagnosis of this agent is very hard and it can be confirmed if the patient experience at least two of the following:
...

Associated Conditions
Opioid Induced Constipation (OIC), Chronic idiopathic constipation (CIC), Refractory Chronic idiopathic constipation
Associated Therapies
-
Clinical Trials
Related News

Prucalopride in Patients With Chronic Idiopathic Constipation

Phase 2
Completed
Conditions
Constipation
Interventions
Drug: placebo
Drug: prucalopride
First Posted Date
2007-12-18
Last Posted Date
2008-05-29
Lead Sponsor
Movetis
Target Recruit Count
87
Registration Number
NCT00575614

A Trial in Healthy Volunteers, to Evaluate the Tolerability and Cardiac Safety of Prucalopride

Phase 1
Completed
Conditions
Constipation
Interventions
Other: Placebo
Drug: prucalopride
First Posted Date
2007-06-20
Last Posted Date
2008-05-29
Lead Sponsor
Movetis
Target Recruit Count
32
Registration Number
NCT00488215

Efficacy and Safety Study of Prucalopride to Treat Chronic Constipation

Phase 3
Completed
Conditions
Constipation
Interventions
Other: Placebo
Drug: Prucalopride
First Posted Date
2007-06-19
Last Posted Date
2013-09-26
Lead Sponsor
Movetis
Target Recruit Count
716
Registration Number
NCT00488137

Efficacy and Safety Study of Prucalopride for the Treatment of Elderly Patients With Chronic Constipation

Phase 3
Completed
Conditions
Constipation
Interventions
Drug: Prucalopride
Other: Placebo
First Posted Date
2007-06-18
Last Posted Date
2008-05-29
Lead Sponsor
Movetis
Target Recruit Count
303
Registration Number
NCT00487422

Efficacy and Safety Study of Prucalopride for the Treatment of Patients With Chronic Constipation

Phase 3
Completed
Conditions
Constipation
Interventions
Drug: Prucalopride
Other: Placebo
First Posted Date
2007-06-13
Last Posted Date
2013-09-25
Lead Sponsor
Movetis
Target Recruit Count
641
Registration Number
NCT00485940

Efficacy and Safety Study of Prucalopride for the Treatment of Chronic Constipation

Phase 3
Completed
Conditions
Constipation
Interventions
Other: Placebo
Drug: Prucalopride
First Posted Date
2007-06-07
Last Posted Date
2013-04-11
Lead Sponsor
Movetis
Target Recruit Count
620
Registration Number
NCT00483886
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