Sodium bicarbonate
- Generic Name
- Sodium bicarbonate
- Brand Names
- Alka-seltzer, Alka-seltzer Fruit Chews, Alka-seltzer Heartburn Relief, Bi-peglyte, Bibag, Bicart, Bss Ophthalmic Solution, Ceo-two, Colyte, Gavilyte-C, Gavilyte-G, Gavilyte-H and Bisacodyl, Gavilyte-N, Golytely, H.E.L.P.bicel, Hema Bp-38, Hemacart, Konvomep, Nulytely, Peglyte, Phoxillum, Physioneal 40, Prismasol, Zegerid, Zegerid Reformulated Aug 2006, Zegerid With Magnesium Hydroxide
- Drug Type
- Small Molecule
- Chemical Formula
- CHNaO3
- CAS Number
- 144-55-8
- Unique Ingredient Identifier
- 8MDF5V39QO
- Background
Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
- Indication
Sodium bicarbonate is used for the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Also is indicated in severe diarrhea which is often accompanied by a significan...
- Associated Conditions
- Barbiturate intoxication, Breast Cancer, Constipation, Dental Decay, Duodenal Ulcer, Dyspepsia, Gastro-esophageal Reflux Disease (GERD), Gingival Bleeding, Heartburn, Helicobacter Infections, Hyperkalemia, Ischaemia, Metabolic Acidosis, Myocardial Infarction, Plaque, Dental, Pruritis of the skin, Skin Irritation, Upper GI Bleeding, Upset stomach, Zollinger-Ellison Syndrome, Abdominal bloating, Benign, active Gastric Ulcer, Methyl alcohol poisoning, Prophylaxis of Contrast-induced nephropathy, Salicylate poisoning, Severe Diarrhea, Swelling of the gums
- Associated Therapies
- Bowel preparation therapy
Evaluation of Sodium Bicarbonate to Reduce the Incidence of Contrast Induced Chronic Kidney Injury in Patients With Kidney Disease
- First Posted Date
- 2009-06-30
- Last Posted Date
- 2012-08-23
- Lead Sponsor
- MD Scientific
- Target Recruit Count
- 391
- Registration Number
- NCT00930436
- Locations
- 🇺🇸
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
🇺🇸Stony Brook University Medical Center, Stony Brook, New York, United States
🇺🇸Mt Sinai School of Medcine, New York, New York, United States
Prevention of Acute Kidney Injury in Cardiac Surgery Patients
- Conditions
- Interventions
- First Posted Date
- 2009-06-16
- Last Posted Date
- 2014-04-15
- Lead Sponsor
- Community Medical Center, Scranton, PA
- Target Recruit Count
- 92
- Registration Number
- NCT00921518
- Locations
- 🇺🇸
Community Medical Center, Scranton, Pennsylvania, United States
Sodium Bicarbonate Supplementation in Chronic Kidney Disease Evaluation of Dose Response, Safety and Beneficial Effects
- First Posted Date
- 2009-04-27
- Last Posted Date
- 2022-08-30
- Lead Sponsor
- Albert Einstein College of Medicine
- Target Recruit Count
- 20
- Registration Number
- NCT00888290
- Locations
- 🇺🇸
Albert Einstein College of Medicine/ Montefiore Medical Center, Bronx, New York, United States
Bicarbonate in Cardiac Surgery
- Conditions
- Interventions
- First Posted Date
- 2009-04-09
- Last Posted Date
- 2012-08-01
- Lead Sponsor
- Austin Health
- Target Recruit Count
- 427
- Registration Number
- NCT00878956
- Locations
- 🇳🇿
Waikato Hospital, Hamilton, New Zealand
🇦🇺Austin Hospital, Melbourne, Victoria, Australia
🇳🇿Auckland City Hospital, Auckland, New Zealand
Randomized Multicenter Cross-over Study to Compare the Effect of Physioneal 35 to 40 on the Protein Metabolism
- Conditions
- Interventions
- First Posted Date
- 2008-10-21
- Last Posted Date
- 2015-06-04
- Lead Sponsor
- University of Erlangen-Nürnberg Medical School
- Target Recruit Count
- 5
- Registration Number
- NCT00776191
- Locations
- 🇩🇪
Pediatric Nephrology, Universiy Children's Hospital, Cologne, Germany
🇩🇪Dept. of Pediatric Nephrology, University Hospital Erlangen, Erlangen, Germany
🇩🇪Dept. of Pediatric Nephrology, University of Hannover, Hannover, Germany
Bicarbonate and Lipocalin in Systemic Inflammatory Response Syndrome (SIRS) Study
- Conditions
- Interventions
- First Posted Date
- 2008-06-30
- Last Posted Date
- 2014-06-30
- Lead Sponsor
- Austin Health
- Target Recruit Count
- 70
- Registration Number
- NCT00706771
- Locations
- 🇦🇺
Austin Hospital, Heidelberg, Melbourne, Victoria, Australia
🇦🇺Royal Melbourne Hospital, Melbourne, Victoria, Australia
Prevention of Contrast-Induced Nephropathy With Sodium Bicarbonate Bolus Injection
- Conditions
- Interventions
- First Posted Date
- 2008-06-18
- Last Posted Date
- 2010-07-20
- Lead Sponsor
- Osaka General Medical Center
- Target Recruit Count
- 59
- Registration Number
- NCT00700375
- Locations
- 🇯🇵
Osaka General Medical Center, Osaka, Japan
A Pharmacodynamic Study Comparing Zegerid® and Prilosec OTC® (CL2007-17 )(P07813)(COMPLETED)
- Conditions
- Interventions
- First Posted Date
- 2008-05-07
- Last Posted Date
- 2015-03-11
- Lead Sponsor
- Bayer
- Target Recruit Count
- 60
- Registration Number
- NCT00674115
Sodium Bicarbonate in Cardiac Surgery Study
- Conditions
- Interventions
- First Posted Date
- 2008-05-06
- Last Posted Date
- 2012-08-01
- Lead Sponsor
- Austin Health
- Target Recruit Count
- 350
- Registration Number
- NCT00672334
- Locations
- 🇦🇺
Austin Health, Melbourne, Victoria, Australia
🇩🇪Charité University Medicine, Berlin, Germany
🇨🇦University of Alberta, Edmonton, Alberta, Canada
Effects of Hydration to Prevent Contrast Induced Nephropathy in PCI for ST-elevation Myocardial Infarction.
- Conditions
- Interventions
- First Posted Date
- 2008-03-20
- Last Posted Date
- 2010-11-30
- Lead Sponsor
- Arcispedale Santa Maria Nuova-IRCCS
- Target Recruit Count
- 599
- Registration Number
- NCT00639912
- Locations
- 🇮🇹
Arcispedale S. Maria Nuova, Reggio Emilia, Emilia-Romagna, Italy
🇮🇹Dipartimento di Cardiologia, Ospedale di Lavagna, Lavagna, Genova, Italy
🇮🇹Azienda Ospedaliera Universitaria S. Anna, Ferrara, Emilia-romagna, Italy
Drug Development Updates
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