Naproxen

Generic Name
Naproxen
Brand Names
Aleve, Aleve PM, Aleve-D, Anaprox, Naprelan, Naprosyn, Sallus, Sudafed Sinus & Pain, Treximet, Vimovo
Drug Type
Small Molecule
Chemical Formula
C14H14O3
CAS Number
22204-53-1
Unique Ingredient Identifier
57Y76R9ATQ
Background

Naproxen is classified as a nonsteroidal anti-inflammatory dug (NSAID) and was initially approved for prescription use in 1976 and then for over-the-counter (OTC) use in 1994. It can effectively manage acute pain as well as pain related to rheumatic diseases, and has a well studied adverse effect profile. Given its overall tolerability and effectiveness, nap...

Indication

Naproxen is indicated for the management of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and for the relief of mild to moderate pain. Further, it is first-line therapy for osteoarthritis, acute gouty arthritis, dysmenorrhea, and musculoskelet...

Associated Conditions
Acute Gouty Arthritis, Acute Migraine, Ankylosing Spondylitis (AS), Back pain, Bursitis, Extra-Articular Rheumatism, Fever, Flu caused by Influenza, Headache, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Migraine, Muscle Spasms, Nasal Congestion, Osteoarthritis (OA), Pain, Post Traumatic Pain, Postoperative pain, Primary Dysmenorrhoea, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Seasonal Allergic Rhinitis, Sinusitis, Tendinitis, Toothache, Articular inflammation
Associated Therapies
-
Clinical Trials
Related News

Comparing Naproxen to Sumatriptan for Emergency Headache Patients

First Posted Date
2007-03-21
Last Posted Date
2018-05-31
Lead Sponsor
Montefiore Medical Center
Target Recruit Count
401
Registration Number
NCT00449787
Locations
🇺🇸

Columbia University Medical Center, New York, New York, United States

🇺🇸

Montefiore Medical Center, Bronx, New York, United States

Study of Flavocoxid (Limbrel) vs Naproxen in Subjects With Mod-Severe Osteoarthritis of the Knee

First Posted Date
2007-02-14
Last Posted Date
2015-10-21
Lead Sponsor
Primus Pharmaceuticals
Target Recruit Count
350
Registration Number
NCT00435292
Locations
🇺🇸

Primus Pharmaceuticals, Inc, Scottsdale, Arizona, United States

To Evaluate the Safety and Efficacy of Trexima in the Acute Treatment of Migraine Headaches

Phase 3
Completed
Conditions
Migraine Headaches
First Posted Date
2007-02-12
Last Posted Date
2007-02-12
Lead Sponsor
POZEN
Target Recruit Count
1400
Registration Number
NCT00433732
Locations
🇺🇸

Pozen, Inc., Chapel Hill, North Carolina, United States

🇺🇸

Little Rock Family Practice Clinic, Little Rock, Arkansas, United States

To Evaluate the Safety and Efficacy of Trexima in the Acute Treatment of Migrane Headaches

Phase 3
Completed
Conditions
Migraine Headaches
First Posted Date
2007-02-12
Last Posted Date
2007-02-12
Lead Sponsor
POZEN
Target Recruit Count
1200
Registration Number
NCT00434083
Locations
🇺🇸

Pozen, Inc., Chapel Hill, North Carolina, United States

🇺🇸

Nashville Neuroscience Group, PC, Nashville, Tennessee, United States

A Study Of The Effect Of CE-224535 On Knee OA (Osteoarthritis) Pain

Phase 2
Terminated
Conditions
Osteoarthritis
Interventions
Drug: naproxen
Drug: placebo
Drug: CE-224535
First Posted Date
2007-01-05
Last Posted Date
2018-12-05
Lead Sponsor
Pfizer
Target Recruit Count
212
Registration Number
NCT00418782
Locations
🇺🇸

Pfizer Investigational Site, Spokane, Washington, United States

Effects of Naproxen on Physical Performance

Phase 4
Terminated
Conditions
Healthy
First Posted Date
2006-12-13
Last Posted Date
2007-10-11
Lead Sponsor
University of Oklahoma
Target Recruit Count
40
Registration Number
NCT00410995
Locations
🇺🇸

Family Practice - CMT, Tulsa, Oklahoma, United States

A Study Of The Effect Of CJ-023,423 On The Incidence Of Stomach Ulcers

Phase 1
Completed
Conditions
Osteoarthritis
Interventions
Drug: placebo
Drug: CJ-023,423
Drug: naproxen
First Posted Date
2006-10-25
Last Posted Date
2008-03-24
Lead Sponsor
Pfizer
Target Recruit Count
340
Registration Number
NCT00392080
Locations
🇺🇸

Pfizer Investigational Site, Chesapeake, Virginia, United States

Study Evaluating the Gastrointestinal Safety of PLA-695 Compared to Placebo and Naproxen

Phase 1
Completed
Conditions
Healthy
First Posted Date
2006-08-21
Last Posted Date
2008-08-05
Lead Sponsor
Wyeth is now a wholly owned subsidiary of Pfizer
Registration Number
NCT00366262

Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen

First Posted Date
2006-06-29
Last Posted Date
2021-03-03
Lead Sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Target Recruit Count
24081
Registration Number
NCT00346216
Locations
🇺🇸

Orange County Research Center, Tustin, California, United States

🇺🇸

AnMed Health, Anderson, South Carolina, United States

🇺🇸

Wagdy W. Kades, MD, Inc., Los Angeles, California, United States

and more 1037 locations

Safety, Efficacy and Acceptability of Flavocoxid (Limbrel)A Pilot Study

Not Applicable
Completed
Conditions
Osteoarthritis
Interventions
Dietary Supplement: flavocoxid
Drug: Naproxen
First Posted Date
2006-03-15
Last Posted Date
2015-10-21
Lead Sponsor
Primus Pharmaceuticals
Target Recruit Count
60
Registration Number
NCT00303017
Locations
🇺🇸

Timothy Truitt MD, Melbourne, Florida, United States

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