Lorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic. It was developed by DJ Richards, presented and marketed initially by Wyeth Pharmaceuticals in the USA in 1977. The first historic FDA label approval is reported in 1985 by the company Mutual Pharm.
Lorazepam is FDA-approved for the short-term relief of anxiety symptoms related to anxiety disorders and anxiety associated with depressive symptoms such as anxiety-associated insomnia. It is as well used as an anesthesia premedication in adults to relieve anxiety or to produce sedation/amnesia and for the treatment of status epilepticus.
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GSK Investigational Site, La Jolla, California, United States
GSK Investigational Site, Barcelona, Spain
Queen Elizabeth Central Hospital, Paediatric Dept, Box 360, Blantyre, Malawi
Virginia Commonwealth University Medical Center, Richmond, Virginia, United States
Medical University of South Carolina - Center for Drug and Alcohol Programs, Charleston, South Carolina, United States
GSK Investigational Site, Zwolle, Netherlands
UCLA, Los Angeles, California, United States
Children's National Medical Center, Washington, District of Columbia, United States
Case Western Reserve University, Cleveland, Ohio, United States
Vanderbilt University Medical Center, Nashville, Tennessee, United States
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