PF-04457845

Generic Name: PF-04457845

Drug Type: Small Molecule

Chemical Formula: C_₂₃H_₂₀F_₃N_₅O_₂

CAS Number: 1020315-31-4

Unique Ingredient Identifier: H4C81M8YYW

Background: PF-04457845 is under investigation in Fear Conditioning. PF-04457845 has been investigated for the treatment of Tourette Syndrome and Cannabis Dependence.

Clinical Trials

A Study of JZP150 in Adults With Posttraumatic Stress Disorder

Phase 2

Completed

Conditions: Post Traumatic Stress Disorder

Interventions: Drug: Placebo
Drug: JZP150

First Posted Date: 2022-01-05

Last Posted Date: 2024-12-31

Lead Sponsor: Jazz Pharmaceuticals

Target Recruit Count: 282

Registration Number: NCT05178316

Locations: 🇺🇸
Clinical Innovations Inc., Santa Ana, California, United States
🇺🇸
Global Medical Institutes, LLC: Princeton Medical Institute, Princeton, New Jersey, United States
🇺🇸
Richmond Behavioral Associates, Staten Island, New York, United States

and more 46 locations

Fatty Acid Amide Hydrolase (FAAH) Inhibitor Treatment of Cannabis Use Disorder (CUD)

Phase 2

Completed

Conditions: Cannabis Use Disorder

Interventions: Drug: PF 04457845
Drug: Placebo Oral Tablet

First Posted Date: 2017-12-29

Last Posted Date: 2024-02-14

Lead Sponsor: Yale University

Target Recruit Count: 228

Registration Number: NCT03386487

Locations: 🇺🇸
Connecticut Mental Health Center, New Haven, Connecticut, United States
🇺🇸
Columbia University Medical College / New York State Psychiatric Institute, New York, New York, United States
🇺🇸
Johns Hopkins University, Baltimore, Maryland, United States

and more 1 locations

A Study To Assess the Effects Of PF-04457845 On BOLD fMRI In Subjects With Post Traumatic Stress Disorder

Phase 2

Terminated

Conditions: Post-Traumatic Stress Disorder

Interventions: Drug: Placebo
Drug: PF-04457845

First Posted Date: 2014-08-13

Last Posted Date: 2016-06-29

Lead Sponsor: Pfizer

Target Recruit Count: 14

Registration Number: NCT02216097

Locations: 🇺🇸
NYU CTSI Research Pharmacy (Drug Shipment Address), New York, New York, United States
🇺🇸
Clinical and Translational Science Institute (CTSI), New York, New York, United States
🇺🇸
NYU School of Medicine, New York, New York, United States

FAAH Inhibitor Trial for Adults With Tourette Syndrome

Phase 1

Terminated

Conditions: Tourette Syndrome

Interventions: Drug: Placebo
Drug: PF-04457845

First Posted Date: 2014-05-08

Last Posted Date: 2018-10-29

Lead Sponsor: Yale University

Target Recruit Count: 5

Registration Number: NCT02134080

Locations: 🇺🇸
Connecticut Mental Health Center, New Haven, Connecticut, United States

Cannabinoid Augmentation of Fear Response in Humans

Early Phase 1

Completed

Conditions: Fear Conditioning

Interventions: Drug: PF-04457845
Drug: Placebo

First Posted Date: 2012-08-15

Last Posted Date: 2022-03-11

Lead Sponsor: Yale University

Target Recruit Count: 31

Registration Number: NCT01665573

Locations: 🇺🇸
VA Connecticut Healthcare System, West Haven, Connecticut, United States

Safety and Efficacy of a FAAH-Inhibitor to Treat Cannabis Withdrawal

Phase 2

Completed

Conditions: Cannabis Dependence

Interventions: Drug: PF-04457845
Drug: Placebo

First Posted Date: 2012-06-13

Last Posted Date: 2023-02-23

Lead Sponsor: Yale University

Target Recruit Count: 70

Registration Number: NCT01618656

Locations: 🇺🇸
Yale University School of Medicine, New Haven, Connecticut, United States

Study To Establish The Effects Of PF-04457845 On Sleep In Healthy Volunteers

Phase 1

Completed

Conditions: Sleep
Healthy

Interventions: Drug: PF-04457845 / matched placebo

First Posted Date: 2010-03-25

Last Posted Date: 2018-12-04

Lead Sponsor: Pfizer

Target Recruit Count: 30

Registration Number: NCT01092845

Locations: 🇺🇸
Pfizer Investigational Site, New York, New York, United States

A Study To Establish The Effects Of PF-04457845 On Sleep In Healthy Volunteers

Phase 1

Terminated

Conditions: Sleep
Healthy Volunteers

Interventions: Drug: PF-04457845 / matched placebo

First Posted Date: 2009-10-27

Last Posted Date: 2010-07-08

Lead Sponsor: Pfizer

Target Recruit Count: 18

Registration Number: NCT01002625

Locations: 🇺🇸
Pfizer Investigational Site, New York, New York, United States

A Study To Investigate Whether PF-04457845 Is Effective In Treating Pain, Is Safe And Tolerable In Patients With Osteoarthritis Of The Knee

Phase 2

Completed

Conditions: Osteoarthritis, Knee

Interventions: Drug: Naproxen
Drug: PF-04457845

First Posted Date: 2009-09-22

Last Posted Date: 2017-09-19

Lead Sponsor: Pfizer

Target Recruit Count: 76

Registration Number: NCT00981357

Locations: 🇺🇸
Arthritis & Rheumatic Care Center, Miami, Florida, United States
🇺🇸
CEDRA Clinical Research, LLC, San Antonio, Texas, United States
🇸🇪
Centrum for klinisk provning, Goteborg, Sweden

and more 3 locations

Evaluation Of The Relative Bioavailability Of PF-04457845 Tablet To Solution Formulation And Food Effect In Healthy Subjects

Phase 1

Completed

Conditions: Healthy Volunteers

Interventions: Drug: PF-04457845

First Posted Date: 2009-06-11

Last Posted Date: 2009-07-10

Lead Sponsor: Pfizer

Target Recruit Count: 12

Registration Number: NCT00918164

Locations: 🇸🇬
Pfizer Investigational Site, Singapore, Singapore

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