Hydrocortisone

Generic Name: Hydrocortisone

Brand Names: Ala-cort, Ala-scalp, Alcortin, Alkindi, Anusol HC, Aquanil HC, Casporyn HC, Cipro, Cipro HC, Colocort, Cortaid, Cortane-B, Cortef, Cortenema, Cortisporin, Cortizone-10, Dermacort, Dermarest Eczema, Dermazene, Home Papkit, Hydroskin, Monistat Itch Relief, Neosporin Eczema, Preparation H Hydrocortisone, Procto-med, Procto-pak, Proctocort, Proctol, Proctosedyl, Proctosol, Proctozone HC, Scalpicin Itch Relief, Texacort, Vanoxide-HC, Xerese, Plenadren, Efmody

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₃₀O_₅

CAS Number: 50-23-7

Unique Ingredient Identifier: WI4X0X7BPJ

Background: Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions. It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.

Hydrocortisone was granted FDA approval on 5 August 1952.

Indication: Otic solutions are indicated for infections of the external auditory canal caused by susceptible organisms and with inflammation. Hydrocortisone tablets are indicated for certain endocrine, rheumatic, collagen, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, gastrointestinal, and other conditions. A hydrocortisone enema is indicated fo...

Associated Conditions: Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Adrenal Insufficiency, Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergic corneal marginal ulcers, Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Contact Dermatitis, Crohn's Disease (CD), Dermatitis, Dermatomyositis (DM), Dermatosis, Drug hypersensitivity reaction, Epicondylitis, Erythroblastopenia, Fissure;Anal, Haemorrhoids, Herpes Labialis, Hypercalcemia of Malignancy, Immune Thrombocytopenia (ITP), Infection of the Fenestration Cavity, Infection of the Mastoidectomy Cavity, Iridocyclitis, Iritis, Itching caused by Hemorrhoids, Itching of the Anus, Keratitis, Leukemias, Loeffler's syndrome, Lymphoma, Lymphomas NEC, Mycosis Fungoides (MF), Ophthalmia, Sympathetic, Optic Neuritis, Pain caused by Hemorrhoids, Pemphigus, Posterior Uveitis, Posttraumatic Osteoarthritis, Primary adrenocortical insufficiency, Proctitis, Proteinuria, Pruritis of the skin, Psoriatic Arthritis, Rectal inflammations NEC, Rheumatic heart disease, unspecified, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Secondary adrenocortical insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Skin Diseases, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Tenosynovitis, Acute rheumatic carditis, Anterior eye segment inflammation, Cryptitis, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Fulminating Pulmonary Tuberculosis, Non-suppurative Thyroiditis, Severe Erythema multiforme, Severe Psoriasis, Subacute Bursitis, Superficial infection of the external auditory canal with inflammation, Symptomatic Sarcoidosis, Systemic Dermatomyositis, Varicella-zoster virus acute retinal necrosis

Associated Therapies: Palliative Treatment

Clinical Trials

HYPAR Trial - Hydrocortisone vs. Pasireotide in Reducing Pancreatic Surgery Complications

Phase 4

Active, not recruiting

Conditions: Pancreatic Fistula
Pancreatic Neoplasms

Interventions: Drug: Hydrocortisone
Drug: Pasireotide

First Posted Date: 2016-05-17

Last Posted Date: 2020-08-24

Lead Sponsor: Helsinki University Central Hospital

Target Recruit Count: 126

Registration Number: NCT02775227

Locations: 🇫🇮
Helsinki University Central Hospital, Helsinki, Finland

Circulating MicroRNAs in Understanding Pathogenesis of Systemic Lupus Erythematosis

Phase 1

Completed

Conditions: Systemic Lupus Erythematosis

Interventions: Drug: Cyclophosphamide
Drug: Hydroxychloroquine
Drug: Hydrocortisone

First Posted Date: 2016-04-29

Last Posted Date: 2016-04-29

Lead Sponsor: Cairo University

Target Recruit Count: 100

Registration Number: NCT02756546

Investigating the Central and Peripheral Mechanisms by Which Glucocorticoids Affect Hunger

Phase 1

Completed

Conditions: Obesity

Interventions: Other: saline
Drug: hydrocortisone

First Posted Date: 2016-03-29

Last Posted Date: 2022-05-25

Lead Sponsor: Yale University

Target Recruit Count: 28

Registration Number: NCT02722200

Locations: 🇺🇸
Yale University, New Haven, Connecticut, United States

Evaluation of Efficacy of Aloevera in the Treatment of Oral Submucous Fibrosis- A Clinical Study

Phase 3

Completed

Conditions: Oral SubMucous Fibrosis

Interventions: Drug: aloevera juice
Drug: Hydrocortisone
Drug: aloevera gel
Drug: Hyaluronic Acid
Drug: antioxidant

First Posted Date: 2016-03-21

Last Posted Date: 2016-03-21

Lead Sponsor: The Oxford Dental College, Hospital and Research Center, Bangalore, India

Target Recruit Count: 74

Registration Number: NCT02714543

Hydrocortisone Treatment In Systemic Low Blood Pressure During Hypothermia in Asphyxiated Newborns

Phase 2

Completed

Conditions: Hypoxic-Ischemic Encephalopathy
Asphyxia

Interventions: Drug: Placebo
Drug: Hydrocortisone

First Posted Date: 2016-03-07

Last Posted Date: 2023-04-21

Lead Sponsor: Semmelweis University

Target Recruit Count: 32

Registration Number: NCT02700828

Locations: 🇭🇺
Semmelweis University, 1st Department of Paediatrics, Budapest, Pest, Hungary

Effect of Hydrocortisone on Improving Outcome of Pneumatic Reduction of Infantile Intussusception

Not Applicable

Recruiting

Conditions: Intussusception

Interventions: Drug: Saline
Drug: Hydrocortisone

First Posted Date: 2016-02-25

Last Posted Date: 2024-08-27

Lead Sponsor: Cairo University

Target Recruit Count: 80

Registration Number: NCT02691858

Locations: 🇪🇬
Cairo University Pediatric Hospital, Cairo, Egypt

Pharmacokinetics and Bioavailability of Hydrocortisone Acetate Suppositories

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Cortenema
Drug: Hydrocortisone Acetate

First Posted Date: 2016-02-02

Last Posted Date: 2017-07-28

Lead Sponsor: Cristcot LLC

Target Recruit Count: 16

Registration Number: NCT02671058

Supplemental Corticosteroids in Cirrhotic Hypotensive Patients With Suspicion of Sepsis

Phase 3

Terminated

Conditions: Liver Cirrhosis

Interventions: Drug: NaCL 0.9%
Drug: Hydrocortisone

First Posted Date: 2015-11-11

Last Posted Date: 2021-01-22

Lead Sponsor: Universitaire Ziekenhuizen KU Leuven

Target Recruit Count: 100

Registration Number: NCT02602210

Locations: 🇬🇧
Derriford Hospital, Plymouth, United Kingdom
🇪🇸
Hospital General Universitario Gregorio Maranon, Madrid, Spain
🇪🇸
Hospital Universitario Ramón y Cajal, Madrid, Spain

and more 7 locations