Hydrocortisone

Generic Name
Hydrocortisone
Brand Names
Ala-cort, Ala-scalp, Alcortin, Alkindi, Anusol HC, Aquanil HC, Casporyn HC, Cipro, Cipro HC, Colocort, Cortaid, Cortane-B, Cortef, Cortenema, Cortisporin, Cortizone-10, Dermacort, Dermarest Eczema, Dermazene, Home Papkit, Hydroskin, Monistat Itch Relief, Neosporin Eczema, Preparation H Hydrocortisone, Procto-med, Procto-pak, Proctocort, Proctol, Proctosedyl, Proctosol, Proctozone HC, Scalpicin Itch Relief, Texacort, Vanoxide-HC, Xerese, Plenadren, Efmody
Drug Type
Small Molecule
Chemical Formula
C21H30O5
CAS Number
50-23-7
Unique Ingredient Identifier
WI4X0X7BPJ
Background

Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions. It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.

Hydrocortisone was granted FDA approval on 5 August 1952.

Indication

Otic solutions are indicated for infections of the external auditory canal caused by susceptible organisms and with inflammation. Hydrocortisone tablets are indicated for certain endocrine, rheumatic, collagen, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, gastrointestinal, and other conditions. A hydrocortisone enema is indicated fo...

Associated Conditions
Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Adrenal Insufficiency, Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergic corneal marginal ulcers, Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Contact Dermatitis, Crohn's Disease (CD), Dermatitis, Dermatomyositis (DM), Dermatosis, Drug hypersensitivity reaction, Epicondylitis, Erythroblastopenia, Fissure;Anal, Haemorrhoids, Herpes Labialis, Hypercalcemia of Malignancy, Immune Thrombocytopenia (ITP), Infection of the Fenestration Cavity, Infection of the Mastoidectomy Cavity, Iridocyclitis, Iritis, Itching caused by Hemorrhoids, Itching of the Anus, Keratitis, Leukemias, Loeffler's syndrome, Lymphoma, Lymphomas NEC, Mycosis Fungoides (MF), Ophthalmia, Sympathetic, Optic Neuritis, Pain caused by Hemorrhoids, Pemphigus, Posterior Uveitis, Posttraumatic Osteoarthritis, Primary adrenocortical insufficiency, Proctitis, Proteinuria, Pruritis of the skin, Psoriatic Arthritis, Rectal inflammations NEC, Rheumatic heart disease, unspecified, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Secondary adrenocortical insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Skin Diseases, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Tenosynovitis, Acute rheumatic carditis, Anterior eye segment inflammation, Cryptitis, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Fulminating Pulmonary Tuberculosis, Non-suppurative Thyroiditis, Severe Erythema multiforme, Severe Psoriasis, Subacute Bursitis, Superficial infection of the external auditory canal with inflammation, Symptomatic Sarcoidosis, Systemic Dermatomyositis, Varicella-zoster virus acute retinal necrosis
Associated Therapies
Palliative Treatment

Stress Doses of Hydrocortisone on Coagulation Dysfunction in Patients With Septic Shock

Phase 3
Completed
Conditions
Interventions
First Posted Date
2014-10-17
Last Posted Date
2014-10-17
Lead Sponsor
Nanjing PLA General Hospital
Target Recruit Count
84
Registration Number
NCT02266589

Hyperglycemia and Effects of Daily 100 mg Versus 200 mg of Hydrocortisone Therapy in Patients With Septic Shock

Phase 4
Completed
Conditions
Interventions
First Posted Date
2014-10-17
Last Posted Date
2017-10-06
Lead Sponsor
Srinakharinwirot University
Target Recruit Count
80
Registration Number
NCT02266264
Locations
🇹🇭

Department of Medicine, Faculty of Medicine, Srinakharinwirot University, Ongkharak, Nakhon nayok, Thailand

Hormonal Mechanisms of Sleep Restriction

First Posted Date
2014-10-06
Last Posted Date
2023-11-07
Lead Sponsor
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Target Recruit Count
40
Registration Number
NCT02256865
Locations
🇺🇸

Los Angeles Biomedical Research Institute, Torrance, California, United States

Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions

First Posted Date
2014-07-15
Last Posted Date
2014-07-15
Lead Sponsor
West China Hospital
Target Recruit Count
100
Registration Number
NCT02190994
Locations
🇨🇳

West China Hospital, Sichuan University, Chengdu, Sichuan, China

Biomarker(s) for Glucocorticoids

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2014-06-02
Last Posted Date
2021-04-12
Lead Sponsor
Vastra Gotaland Region
Target Recruit Count
11
Registration Number
NCT02152553
Locations
🇸🇪

Sahlgrenska University Hospital, Gothenburg, Vastra Gotaland Region, Sweden

Effects of Stress Doses of Hydrocortisone on Coagulation Dysfunction in Patients With Septic Shock

First Posted Date
2014-04-15
Last Posted Date
2014-04-15
Lead Sponsor
Nanjing PLA General Hospital
Target Recruit Count
240
Registration Number
NCT02114710

Endoscopic Treatment of Salivary Glands Affected by Sjögren's Syndrome

First Posted Date
2014-04-11
Last Posted Date
2017-05-11
Lead Sponsor
Derk Jan Jager
Target Recruit Count
50
Registration Number
NCT02112019
Locations
🇳🇱

VU Medical Center department of Maxillofacial surgery, Amsterdam, Netherlands

Ultradian Subcutaneous Hydrocortisone Infusion in Addison Disease and Congenital Adrenal Hyperplasia

First Posted Date
2014-03-26
Last Posted Date
2024-06-07
Lead Sponsor
Haukeland University Hospital
Target Recruit Count
8
Registration Number
NCT02096510
Locations
🇳🇴

University Hospital Helse Bergen, Bergen, Norway

Association Between Low Cortisol Levels and Whiplash Syndrome

First Posted Date
2014-03-18
Last Posted Date
2014-08-28
Lead Sponsor
Soroka University Medical Center
Target Recruit Count
90
Registration Number
NCT02090309
Locations
🇮🇱

Soroka Medical Center, Beer Sheva, Negev, Israel

🇮🇱

Soroka University Medical Center, Beer Sheva, Negev, Israel

Peri-Operative Steroid Management in Patients

First Posted Date
2014-03-11
Last Posted Date
2018-04-11
Lead Sponsor
Washington University School of Medicine
Target Recruit Count
43
Registration Number
NCT02084134
Locations
🇺🇸

Washington University School of Medicine, Saint Louis, Missouri, United States

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