Overview
Streptomycin, an antibiotic derived from Streptomyces griseus, was the first aminoglycoside to be discovered and used in practice in the 1940s. Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activity. Although streptomycin was the first antibiotic determined to be effective against mycobacterium tuberculosis, it has fallen out of favor due to resistance and is now primarily used as adjunctive treatment in cases of multi-drug resistant tuberculosis.
Indication
Although streptomycin was the first antibiotic available for the treatment of mycobacterium tuberculosis, it is now largely a second line option due to resistance and toxicity. Streptomycin may also be used to treat a variety of other infections caused by susceptible strains of aerobic bacteria where other less toxic agents are ineffective. Examples include: Yersinia pestis, Francisella tularensis, Brucella, Calymmatobacterium granulomatis (donovanosis, granuloma inguinale), H. ducreyi (chancroid), H. influenzae (in respiratory, endocardial, and meningeal infections - concomitantly with another antibacterial agents). K. pneumoniae pneumonia (concomitantly with another antibacterial agent), E.coli, Proteus, A.aerogenes, K. pneumoniae, and Enterococcus faecalis in urinary tract infections, Streptococcus viridans, Enterococcus faecalis (in endocardial infections - concomitantly with penicillin), and Gram-negative bacillary bacteremia (concomitantly with another antibacterial agent).
Associated Conditions
- Bacteremia
- Bacterial Infections caused by susceptible bacteria
- Chancroid
- Disseminated mycobacterium avium complex infection
- Flu caused by Influenza
- Granuloma Inguinale
- Menière's Disease
- Mycobacterium Avium Intracellulare Complex (MAC)
- Mycobacterium kansasii infection
- Mycobacterium marinum infection
- Plague
- Pneumonia
- Tuberculosis (TB)
- Tularemia
- Urinary Tract Infection
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2019/10/01 | Phase 3 | Completed | |||
2015/11/13 | N/A | Completed | Maimónides Biomedical Research Institute of Córdoba | ||
2015/01/06 | Phase 4 | UNKNOWN | Shanghai Pulmonary Hospital, Shanghai, China | ||
2012/08/07 | Phase 2 | Completed | |||
2005/08/10 | Phase 2 | Completed | |||
2001/08/31 | Not Applicable | Completed | |||
2000/02/25 | Phase 2 | Completed | |||
1999/10/19 | Not Applicable | Completed | FDA Office of Orphan Products Development |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| XGen Pharmaceuticals DJB, Inc. | 39822-0706 | INTRAMUSCULAR | 1 g in 1 1 | 8/15/2023 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| STREPTOMYCIN SULFATE FOR INJECTION 1 g/vial | SIN01388P | INJECTION, POWDER, FOR SOLUTION | 1 g/vial | 5/19/1988 |
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| Streptomycin Sulfate Injection | 国药准字H51023731 | 化学药品 | 注射剂(注射液) | 5/14/2021 | |
| Streptomycin Sulfate Injection | 国药准字H20043306 | 化学药品 | 注射剂(注射液) | 5/14/2021 | |
| Streptomycin Sulfate Injection | 国药准字H51023730 | 化学药品 | 注射剂(注射液) | 5/14/2021 | |
| Streptomycin Sulfate Injection | 国药准字H51023729 | 化学药品 | 注射剂(注射液) | 5/14/2021 | |
| Streptomycin Sulfate Injection | 国药准字H32025954 | 化学药品 | 注射剂 | 7/30/2020 | |
| Streptomycin Sulfate Tablets | 国药准字H32024528 | 化学药品 | 片剂 | 5/22/2020 | |
| Streptomycin Sulfate for Injection | 国药准字H13021272 | 化学药品 | 注射剂 | 10/23/2020 | |
| Streptomycin Sulfate for Injection | 国药准字H14024024 | 化学药品 | 注射剂 | 4/20/2020 | |
| Streptomycin Sulfate for Injection | 国药准字H13020649 | 化学药品 | 注射剂 | 10/27/2020 | |
| Streptomycin Sulfate for Injection | 国药准字H42020863 | 化学药品 | 注射剂（溶媒结晶） | 10/11/2022 |
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| No TGA approvals found for this drug. | |||||
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