Clobazam
未知生产厂商
Clobazam is a benzodiazepine used as adjunct treatment in seizures associated with Lennox-Gastaut syndrome.
Clobazam is a benzodiazepine used as adjunct treatment in seizures associated with Lennox-Gastaut syndrome.
The exact mechanism of action for clobazam, a 1,5-benzodiazepine, is not fully understood but is thought to involve the potentiation of GABAergic neurotransmission resulting from binding at the benzodiazepine site of the GABA receptor. Specifically, clobazam binds to the interface of the α and γ-subunit of the GABA receptor. It has a great affinity for the α subunit than the α subunit compared to other 1,4‐benzodiazepines.Binding of clobazam to the GABA receptor causes chloride channels to open, resulting in an influx of chloride and thus hyperpolarization of neurons.
Clobazam is indicated for the adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in patients 2 years of age or older.
