Hydrochlorothiazide

Generic Name: Hydrochlorothiazide

Brand Names: Accuretic, Actelsar Hct, Aldactazide, Altace HCT, Atacand, Atacand Hct, Avalide, Benicar Hct, Diovan Hct, Exforge Hct, Hyzaar, Ifirmacombi, Karvezide, Lopressor Hct, Lotensin Hct, Maxzide, Micardis-hct, Olmetec Plus, Tekturna Hct, Teveten HCT, Tribenzor, Urozide, Vaseretic, Viskazide, Zestoretic, Ziac

Drug Type: Small Molecule

Chemical Formula: C_₇H_₈ClN_₃O_₄S_₂

CAS Number: 58-93-5

Unique Ingredient Identifier: 0J48LPH2TH

Background: Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension. Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and angiotensin converting enzyme inhibitors or angiotensin II receptor blockers.

Hydrochlorothiazide was granted FDA approval on 12 February 1959.

Indication: Hydrochlorothiazide is indicated alone or in combination for the management of edema associated with congestive heart failure, hepatic cirrhosis, nephrotic syndrome, acute glomerulonephritis, chronic renal failure, and corticosteroid and estrogen therapy. Hydrochlorothiazide is also indicated alone or in combination for the management of hypertension.

Associated Conditions: Calcium Nephrolithiasis, Cirrhosis of the Liver, Congestive Heart Failure (CHF), Diabetes Insipidus, Edema, Hypertension, Hypertension, Essential Hypertension, Hypokalemia caused by diuretics, Nephrotic Syndrome, Pre-Eclampsia, Premenstrual tension with edema, Renal tubular acidosis, Sodium retention, Stroke

Associated Therapies: -

Clinical Trials

Efficacy and Tolerability of an Aliskiren-based Treatment Algorithm in Patients With Mild to Moderate Hypertension

Phase 4

Completed

Conditions: Essential Hypertension ( Mild to Moderate)

Interventions: Drug: Aliskiren
Drug: Hydrochlorothiazide
Drug: Amlodipine

First Posted Date: 2008-10-03

Last Posted Date: 2020-08-06

Lead Sponsor: Novartis

Target Recruit Count: 256

Registration Number: NCT00765947

Locations: 🇸🇰
Investigative Site, Bratislava, Slovakia

Blood Pressure Lowering of Aliskiren HCTZ Compared to HCTZ in Stage 2 Systolic Hypertension in Older Population

Phase 4

Completed

Conditions: Hypertension

Interventions: Drug: Aliskiren
Drug: Hydrochlorothiazide

First Posted Date: 2008-09-26

Last Posted Date: 2011-04-04

Lead Sponsor: Novartis

Target Recruit Count: 451

Registration Number: NCT00760266

Locations: 🇺🇸
Sites in USA, East Hanover, New Jersey, United States

Regression of Fatty Heart by Valsartan Therapy

Phase 4

Withdrawn

Conditions: Metabolic Syndrome
Lipotoxicity

Interventions: Drug: Valsartan
Drug: Hydrochlorothiazide

First Posted Date: 2008-09-03

Last Posted Date: 2019-01-17

Lead Sponsor: University of Texas Southwestern Medical Center

Registration Number: NCT00745953

Locations: 🇺🇸
University of Texas Southwestern Medical Center, Dallas, Texas, United States

Study of the Glycemic Effects of Nebivolol Compared With Metoprolol and HCTZ in Diabetic Hypertensive Patients

Phase 4

Completed

Conditions: Hypertension
Type 2 Diabetes Mellitus

Interventions: Drug: Metoprolol ER
Drug: Nebivolol
Drug: HCTZ

First Posted Date: 2008-08-29

Last Posted Date: 2011-07-29

Lead Sponsor: Forest Laboratories

Target Recruit Count: 231

Registration Number: NCT00744237

Locations: 🇺🇸
Forest Investigative Site 49, Tustin, California, United States
🇺🇸
Forest Investigative Site 32, Pembroke Pines, Florida, United States
🇺🇸
Forest Investigative Site 081, Pembroke Pines, Florida, United States

and more 47 locations

Efficacy and Safety of Valsartan/Hydrochlorothiazide Combination Compared to Valsartan Monotherapy or Hydrochlorothiazide Monotherapy in Elderly (>70) With Mild-moderate Hypertension.

Phase 4

Completed

Conditions: Hypertension

Interventions: Drug: Valsartan + HCTZ
Drug: Valsartan
Drug: HCTZ

First Posted Date: 2008-06-17

Last Posted Date: 2011-04-19

Lead Sponsor: Novartis Pharmaceuticals

Target Recruit Count: 384

Registration Number: NCT00698646

Locations: 🇺🇸
Investigative Site, Taylors, South Carolina, United States
🇺🇸
Investigative Sites, Pismo Beach, California, United States
🇺🇸
Investigative site, St George, Utah, United States