Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cell death. It is a derivative of camptothe...
For the treatment of metastatic colorectal cancer (first-line therapy when administered with 5-fluorouracil and leucovorin). Also used in combination with cisplatin for the treatment of extensive small cell lung cancer. Irinotecan is currently under investigation for the treatment of metastatic or recurrent cervical cancer. Also used in combination with fluo...
Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China
Lutheran Hospital - Cancer Centers of Colorado, Golden, Colorado, United States
Intermountain Health Lutheran Hospital, Wheat Ridge, Colorado, United States
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida, United States
CHU de GRENOBLE ALPES, Grenoble, Alpes, France
CHU de BORDEAUX, Bordeaux, France
CHRU Lille, Lille, France
Dana-Farber Cancer Institute, Boston, Massachusetts, United States
Brigham and Women's Hospital, Boston, Massachusetts, United States
Ballarat Oncology and Haematology, Wendouree, Victoria, Australia
Pindara Private Hospital, Gold Coast Cancer Care, Benowa, Queensland, Australia
Cabrini Hospital, Malvern, Victoria, Australia
Sichuan Academy of Medical Sciences and Sichuan Provincial Peoples Hospital, Chengdu, Sichuan, China
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China
Phoenix Children's Hospital, Phoenix, Arizona, United States
The Regents of the University of California - Los Angeles (UCLA Pediatrics), Los Angeles, California, United States
Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana, United States
Fudan University Shanghai Cancer Center, Shanghai, Shanghai, China
Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States
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