Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cell death. It is a derivative of camptothecin. Irinotecan was approved for the treatment of advanced pancreatic cancer in October, 2015 (irinotecan liposome injection, trade name Onivyde).
For the treatment of metastatic colorectal cancer (first-line therapy when administered with 5-fluorouracil and leucovorin). Also used in combination with cisplatin for the treatment of extensive small cell lung cancer. Irinotecan is currently under investigation for the treatment of metastatic or recurrent cervical cancer. Also used in combination with fluorouracil and leucovorin for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy.
Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, United States
Duke Comprehensive Cancer Center, Durham, North Carolina, United States
Hematology Oncology Associates of Illinois - Lake Shore Dr, Chicago, Illinois, United States
Grady Memorial Hospital, Atlanta, Georgia, United States
Emory University Hospital - Atlanta, Atlanta, Georgia, United States
University of Texas - MD Anderson Cancer Center, Houston, Texas, United States
Eastern Cooperative Oncology Group, Boston, Massachusetts, United States
NYU School of Medicine's Kaplan Comprehensive Cancer Center, New York, New York, United States
Bristol Haematology and Oncology Centre, Bristol, England, United Kingdom
U.Z. Gasthuisberg, Leuven, Belgium
National Institute of Oncology, Budapest, Hungary
Cancer Resource Center - Lincoln, Lincoln, Nebraska, United States
Mercy Cancer Center at Mercy Medical Center - North Iowa, Mason City, Iowa, United States
Mayo Clinic Cancer Center, Rochester, Minnesota, United States
Centre Regional Francois Baclesse, Caen, France
Centre Eugene Marquis, Rennes, France
Centre Antoine Lacassagne, Nice, France
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