Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012. Although androgen deprivation therapy (ADT) is the first-line treatment of prostate cancer and remission can be achieve...
Enzalutamide is indicated for the treatment of castration-resistant prostate cancer and metastatic castration-sensitive prostate cancer (mCRPC). It is also used in combination with talazoparib for the treatment of adult patients with HRR gene-mutated mCRPC.
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland, United States
Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington, United States
Investigational Site Number 056007, Brussels, Belgium
Investigational Site Number 056005, Leuven, Belgium
Investigational Site Number 250010, Clermont Ferrand, France
Dana Farber Cancer Institute, Boston, Massachusetts, United States
University of Alabama, Birmingham, Birmingham, Alabama, United States
Mayo Clinic, Rochester, Minnesota, United States
Santa Chiara Hospital, Trento, Italy
Sibley Memorial Hospital, Washington, District of Columbia, United States
Northwestern University, Chicago, Illinois, United States
University of Chicago, Chicago, Illinois, United States
Dana Farber Cancer Institute, Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
Campbelltown Hospital, Campbelltown, New South Wales, Australia
BCCA Vancouver Centre, Vancouver, British Columbia, Canada
Australian Urology Associates, Malvern, Victoria, Australia
Austin Hospital, Heidelberg, Victoria, Australia
Site US10004, New York, New York, United States
Site US10003, Evanston, Illinois, United States
Site US10002, Myrtle Beach, South Carolina, United States
Hospital Clínic i Provincial de Barcelona-Oncology, Barcelona, Spain
Unidad Cnio Ibima de Investigacion en Prostata, Malaga, Spain
Hospital General Universitario Gregorio Marañón, Madrid, Spain
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