Gaboxadol
- Generic Name
- Gaboxadol
- Drug Type
- Small Molecule
- Chemical Formula
- C6H8N2O2
- CAS Number
- 64603-91-4
- Unique Ingredient Identifier
- K1M5RVL18S
- Background
Gaboxadol also known as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP) is an experimental sleep aid drug developed by Lundbeck and Merck, who reported increased deep sleep without the reinforcing effects of benzodiazepines. Development of Gaboxadol was stopped in March 2007 after concerns regarding safety and efficacy. It acts on the GABA system, but in a seemingly different way from benzodiazepines and other sedatives.
- Indication
Investigated for use/treatment in sleep disorders and insomnia.
A Prospective Active-Reference Study of Gaboxadol in Primary Insomnia
Phase 3
Completed
- Conditions
- Primary Insomnia
- First Posted Date
- 2005-09-21
- Last Posted Date
- 2007-03-30
- Lead Sponsor
- H. Lundbeck A/S
- Target Recruit Count
- 675
- Registration Number
- NCT00209937
A Prospective Open-Label Extension Study of Gaboxadol in Primary Insomnia
Phase 3
Completed
- Conditions
- Primary Insomnia
- First Posted Date
- 2005-09-21
- Last Posted Date
- 2007-03-30
- Lead Sponsor
- H. Lundbeck A/S
- Target Recruit Count
- 200
- Registration Number
- NCT00209950
- Locations
- 🇩🇪
Non-US study, principal location:, Regensburg, Germany
An Investigational Study of MK0928 in Adult Outpatients With Insomnia (0928-014)(COMPLETED)
Phase 3
Completed
- Conditions
- Insomnia
- First Posted Date
- 2005-02-16
- Last Posted Date
- 2015-01-14
- Lead Sponsor
- H. Lundbeck A/S
- Target Recruit Count
- 900
- Registration Number
- NCT00103818
Study of MK0928 in Healthy Adult Volunteers in a Model of Insomnia (0928-006)(COMPLETED)
Phase 3
Completed
- Conditions
- Insomnia
- First Posted Date
- 2005-01-24
- Last Posted Date
- 2015-01-14
- Lead Sponsor
- H. Lundbeck A/S
- Target Recruit Count
- 663
- Registration Number
- NCT00102167
Safety of MK0928 on Insomnia in the Elderly (0928-005)(COMPLETED)
Phase 3
Completed
- Conditions
- Insomnia
- First Posted Date
- 2004-11-01
- Last Posted Date
- 2016-11-17
- Lead Sponsor
- H. Lundbeck A/S
- Target Recruit Count
- 320
- Registration Number
- NCT00095043
Adult Primary Insomnia Polysomnographic Study (0928-004)(COMPLETED)
Phase 3
Completed
- Conditions
- Primary Insomnia
- First Posted Date
- 2004-10-22
- Last Posted Date
- 2015-01-14
- Lead Sponsor
- H. Lundbeck A/S
- Target Recruit Count
- 465
- Registration Number
- NCT00094627
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