Tamoxifen

Generic Name: Tamoxifen

Brand Names: Soltamox

Drug Type: Small Molecule

Chemical Formula: C_₂₆H_₂₉NO

CAS Number: 10540-29-1

Unique Ingredient Identifier: 094ZI81Y45

Background: Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations. Tamoxifen is used alone or as an adjuvant in these treatments. Tamoxifen may no longer be the preferred treatment for these types of cancers as patients generally have better survival, side effect profiles, and compliance with anastrozole.

Tamoxifen was granted FDA approval on 30 December 1977.

Indication: Tamoxifen is indicated to treat estrogen receptor positive metastatic breast cancer in adults, as an adjuvant in the treatment of early stage estrogen receptor positive breast cancer in adults, to reduce the risk of invasive breast cancer after surgery and radiation in adult women with ductal carcinoma in situ.

Associated Conditions: Breast Cancer, Contralateral Breast Cancer, Desmoid Tumor, Early Stage Estrogen Receptor (ER) Positive Breast Cancer, Gynecomastia, Invasive Breast Cancer, Ovarian Cancer, Puberty, Precocious, Metastatic Estrogen Receptor Positive Breast Cancer

Associated Therapies: Ovulation induction therapy

Clinical Trials

Prolonged Tamoxifen Compared With Shorter Tamoxifen in Treating Patients Who Have Breast Cancer

Phase 3

Conditions: Breast Cancer

First Posted Date: 2003-01-27

Last Posted Date: 2009-02-09

Lead Sponsor: University of Oxford

Target Recruit Count: 20000

Registration Number: NCT00003016

Locations: 🇬🇧
Atlas Trial Office, Oxford, England, United Kingdom

Combination Chemotherapy in Treating Women With Resected Breast Cancer

Phase 2

Conditions: Breast Cancer

First Posted Date: 2003-01-27

Last Posted Date: 2009-02-09

Lead Sponsor: Institute of Cancer Research, United Kingdom

Registration Number: NCT00033683

Locations: 🇬🇧
St. Georges Hospital Medical School, London, England, United Kingdom
🇬🇧
Huddersfield Royal Infirmary, Huddersfield, West Yorks, England, United Kingdom
🇬🇧
Leicester Royal Infirmary, Leicester, England, United Kingdom

and more 66 locations

Surgery With or Without Lymph Node Removal in Treating Older Women With Stage I or Stage IIA Breast Cancer

Phase 3

Completed

Conditions: Breast Cancer

Interventions: Drug: tamoxifen citrate
Procedure: conventional surgery
Radiation: radiation therapy
Procedure: Axillary clearance

First Posted Date: 2003-01-27

Last Posted Date: 2013-04-04

Lead Sponsor: ETOP IBCSG Partners Foundation

Target Recruit Count: 473

Registration Number: NCT00002528

Locations: 🇦🇺
Royal Prince Alfred Hospital, Sydney, Sydney, New South Wales, Australia
🇦🇺
Sir Charles Gairdner Hospital, Perth, Perth, Western Australia, Australia
🇨🇭
Kantonsspital - St. Gallen, St. Gallen, Switzerland

and more 18 locations

Study of Tamoxifen and Raloxifene (STAR) for the Prevention of Breast Cancer in Postmenopausal Women

Phase 3

Completed

Conditions: Breast Cancer

Interventions: Drug: Tamoxifen
Drug: Raloxifene

First Posted Date: 2003-01-27

Last Posted Date: 2015-10-06

Lead Sponsor: NSABP Foundation Inc

Target Recruit Count: 19747

Registration Number: NCT00003906

Locations: 🇺🇸
Santa Clarita Valley Cancer Center - UCLA, Valencia, California, United States
🇺🇸
Charles A. Sammons Cancer Center, Dallas, Texas, United States
🇺🇸
Abramson Cancer Center at University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, United States

and more 513 locations

Combination Chemotherapy in Treating Women With Breast Cancer

Phase 3

Completed

Conditions: Breast Cancer

First Posted Date: 2003-01-27

Last Posted Date: 2013-05-30

Lead Sponsor: Ludwig-Maximilians - University of Munich

Target Recruit Count: 446

Registration Number: NCT00047099

Locations: 🇩🇪
Klinikum Rechts Der Isar - Technische Universitaet Muenchen, Munich, Germany
🇩🇪
I. Frauenklinik und Hebammenschule der Ludwig-Maximillians Universitaet Muenchen, Munich, Germany

Radiation Therapy With or Without Optional Tamoxifen in Treating Women With Ductal Carcinoma in Situ

Phase 3

Completed

Conditions: Breast Cancer

Interventions: Drug: tamoxifen citrate
Procedure: adjuvant therapy
Radiation: radiation therapy

First Posted Date: 2003-01-27

Last Posted Date: 2022-05-25

Lead Sponsor: Radiation Therapy Oncology Group

Target Recruit Count: 636

Registration Number: NCT00003857

Locations: 🇺🇸
Moore Regional Community Hospital Comprehensive Cancer Center, Pinehurst, North Carolina, United States
🇨🇦
Toronto Sunnybrook Regional Cancer Centre at Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
🇺🇸
Greater Baltimore Medical Center, Baltimore, Maryland, United States

and more 366 locations

S9630, Medroxyprogesterone in Treating Women With Breast Cancer

Phase 3

Completed

Conditions: Breast Cancer
Endometrial Cancer

Interventions: Drug: tamoxifen citrate
Drug: medroxyprogesterone
Procedure: adjuvant therapy

First Posted Date: 2003-01-27

Last Posted Date: 2012-10-31

Lead Sponsor: SWOG Cancer Research Network

Target Recruit Count: 313

Registration Number: NCT00002920

Locations: 🇺🇸
CCOP - Beaumont, Royal Oak, Michigan, United States
🇺🇸
Veterans Affairs Medical Center - Loma Linda (Pettis), Loma Linda, California, United States
🇺🇸
Veterans Affairs Medical Center - Asheville, Asheville, North Carolina, United States

and more 119 locations

Soy Protein Supplement In Treating Hot Flashes in Postmenopausal Women Receiving Tamoxifen for Breast Disease

Phase 2

Completed

Conditions: Hot Flashes
Hot Flushes
Breast Cancer

Interventions: Dietary Supplement: soy protein
Dietary Supplement: isoflavones
Other: Placebo
Drug: Tamoxifen

First Posted Date: 2003-01-27

Last Posted Date: 2016-07-13

Lead Sponsor: Alliance for Clinical Trials in Oncology

Target Recruit Count: 112

Registration Number: NCT00031720

Locations: 🇺🇸
Elkhart General Hospital, Elkhart, Indiana, United States
🇺🇸
Center for Cancer Therapy at LaPorte Hospital and Health Services, La Porte, Indiana, United States
🇺🇸
Kingsbury Center for Cancer Care at Cheshire Medical Center, Keene, New Hampshire, United States

and more 11 locations