Oxytocin

Generic Name
Oxytocin
Brand Names
Pitocin
Drug Type
Biotech
Chemical Formula
-
CAS Number
50-56-6
Unique Ingredient Identifier
1JQS135EYN
Background

Sir Henry H. Dale first identified oxytocin and its uterine contractile properties in 1906. Like all other neurohypophysial hormones, oxytocin is composed of nine amino acids with a disulfide bridge between the Cys 1 and 6 residues. In the mid-1950s, synthetic oxytocin was successfully synthesized by a biochemist named Vincent du Vigneaud; he was later recog...

Indication

Administration of exogenous oxytocin is indicated in the antepartum period to initiate or improve uterine contractions for vaginal delivery in situations where there is fetal or maternal concern. For example, It may be used to induce labor in cases of Rh sensitization, maternal diabetes, preeclampsia at or near term, and when delivery is indicated due to pre...

Associated Conditions
Incomplete Abortion, Inevitable abortion, Postpartum Bleeding
Associated Therapies
Reinforcement of labor
Clinical Trials
Related News

Carbetocin Versus Syntocinon for Prevention of Postpartum Hemorrhage in Cardiac Patients Undergoing Caesarean Section

First Posted Date
2021-11-08
Last Posted Date
2023-06-06
Lead Sponsor
Cairo University
Target Recruit Count
38
Registration Number
NCT05110482
Locations
🇪🇬

Faculty of medicine CAIRO UNIVERISTY, Cairo, Egypt

Oxytocin Versus, Sublingual Misoprostol in the Secondary Prevention of Postpartum Hemorrhage After Vaginal Delivery

Not Applicable
Conditions
Labor Complication
Interventions
Drug: misoprostol
Drug: oxytocin
First Posted Date
2021-10-14
Last Posted Date
2021-10-22
Lead Sponsor
Aswan University Hospital
Target Recruit Count
150
Registration Number
NCT05077540

Hemostatic Effect of Intrauterine Instillation of Oxytocin in Hysteroscopic Myomectomy

Not Applicable
Completed
Conditions
Leiomyoma
Interventions
Other: sterile bacteriostatic water ampule
Drug: Oxytocin
First Posted Date
2021-08-09
Last Posted Date
2023-11-07
Lead Sponsor
Ain Shams Maternity Hospital
Target Recruit Count
60
Registration Number
NCT04996498
Locations
🇪🇬

Ain shams university maternity hospital, Cairo, Abbasia, Egypt

Oxytocin vs Prostaglandins for Labor Induction of Women With an Unfavorable Cervix After 24h of Cervical Ripening

First Posted Date
2021-07-02
Last Posted Date
2022-11-14
Lead Sponsor
University Hospital, Tours
Target Recruit Count
1494
Registration Number
NCT04949633
Locations
🇫🇷

Gynaecology-obstetrics, University Hospital, Angers, Angers, France

🇫🇷

Gynaecology-obstetrics, University Hospital, Bordeaux, Bordeaux, France

🇫🇷

Gynaecology-obstetrics, University Hospital, Brest, Brest, France

and more 7 locations

Maintenance Infusion of Oxytocin Following Elective Cesarean Deliveries

Not Applicable
Completed
Conditions
Postpartum Hemorrhage
Interventions
Drug: Oxytocin
First Posted Date
2021-06-30
Last Posted Date
2022-06-07
Lead Sponsor
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Target Recruit Count
40
Registration Number
NCT04946006
Locations
🇨🇦

Mount Sinai Hospital, Toronto, Ontario, Canada

Amniotomy for Second-trimester Pregnancy Termination

First Posted Date
2021-05-28
Last Posted Date
2023-08-29
Lead Sponsor
Assiut University
Target Recruit Count
60
Registration Number
NCT04906278
Locations
🇪🇬

Woman's Health Hospital - Assiut university, Assiut, Egypt

Oxytocin vs Carbetocin at Cesarean Delivery in Women With Morbid Obesity

Not Applicable
Completed
Conditions
Post Partum Hemorrhage
Interventions
Drug: Oxytocin
Drug: Carbetocin
First Posted Date
2021-05-26
Last Posted Date
2023-02-23
Lead Sponsor
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Target Recruit Count
48
Registration Number
NCT04902729
Locations
🇨🇦

Mount Sinai Hospital, Toronto, Ontario, Canada

Effects of Oxytocin and Vasopressin on Moral Decision Making

Not Applicable
Completed
Conditions
Healthy
Interventions
Drug: Placebo
Drug: Vasopressin
Drug: Oxytocin
First Posted Date
2021-05-18
Last Posted Date
2023-09-21
Lead Sponsor
University of Electronic Science and Technology of China
Target Recruit Count
180
Registration Number
NCT04890470
Locations
🇨🇳

Xiaoxiao Zheng, Sichuan, Sichuan, China

Differential Effects of Oral and Intranasal Oxytocin on Attention Control

Not Applicable
Completed
Conditions
Healthy
Interventions
Drug: Oxytocin
Drug: Placebo
First Posted Date
2021-03-25
Last Posted Date
2021-03-25
Lead Sponsor
University of Electronic Science and Technology of China
Target Recruit Count
151
Registration Number
NCT04815395
Locations
🇨🇳

University of Electronic Science and Technology of China(UESTC), Chengdu, Sichuan, China

Uterotonics for Severe Preeclampsia

Not Applicable
Completed
Conditions
Preeclampsia Severe
Interventions
Drug: Carbetocin
Drug: Oxytocin
Drug: Misoprostol
First Posted Date
2021-02-16
Last Posted Date
2021-02-16
Lead Sponsor
Assiut University
Target Recruit Count
124
Registration Number
NCT04756661
Locations
🇪🇬

Assiut Faculty of Medicine, Assiut, Egypt

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