Donepezil
- Generic Name
- Donepezil
- Brand Names
- Adlarity, Aricept, Namzaric
- Drug Type
- Small Molecule
- Chemical Formula
- C24H29NO3
- CAS Number
- 120014-06-4
- Unique Ingredient Identifier
- 8SSC91326P
- Background
In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and in some cases, is used to manage other ty...
- Indication
Donepezil, administered orally or via transdermal delivery system, is indicated for the treatment of dementia of the Alzheimer's type. It is also available as an extended-release capsule in combination with memantine for the treatment of moderate-to-severe dementia of the Alzheimer's type in patients previously stabilized on 10mg of donepezil hydrochloride o...
- Associated Conditions
- Alzheimer's Disease (AD), Dementia With Lewy Body Disease, Dementia due to Parkinson's disease, Dementia of the Alzheimer's Type, Vascular Dementia (VaD), Moderate Alzheimer's Type Dementia, Severe Alzheimer's Type Dementia
- Associated Therapies
- -
Donepezil Double Blind Trial for ECT Memory Disfunction
- Conditions
- Interventions
- First Posted Date
- 2007-04-24
- Last Posted Date
- 2009-01-27
- Lead Sponsor
- BeerYaakov Mental Health Center
- Target Recruit Count
- 40
- Registration Number
- NCT00465283
- Locations
- 🇮🇱
Beer Yaakov MHC, Beer Yaacov, Israel
Donepezil in Treating Young Patients With Primary Brain Tumors Previously Treated With Radiation Therapy to the Brain
- First Posted Date
- 2007-03-28
- Last Posted Date
- 2018-09-07
- Lead Sponsor
- Wake Forest University Health Sciences
- Target Recruit Count
- 14
- Registration Number
- NCT00452868
- Locations
- 🇺🇸
Wake Forest University Comprehensive Cancer Center, Winston-Salem, North Carolina, United States
🇺🇸Tufts-NEMC Cancer Center, Boston, Massachusetts, United States
Efficacy Study of a ZT-1 Implant in Patients Suffering From Alzheimer's Disease
- First Posted Date
- 2007-01-18
- Last Posted Date
- 2015-01-14
- Lead Sponsor
- Debiopharm International SA
- Target Recruit Count
- 228
- Registration Number
- NCT00423228
- Locations
- 🇦🇺
Central Coast Neuroscience Research, East Gosford, New South Wales, Australia
🇦🇺Hornsby-Kuring-gai Health Service, Hornsby, New South Wales, Australia
🇦🇺The Prince Charles Hospital, Chermside, Queensland, Australia
Donepezil and Brain Activity Patterns in Those at Risk For Alzheimer's Disease
- First Posted Date
- 2006-12-07
- Last Posted Date
- 2018-02-05
- Lead Sponsor
- Vanderbilt University
- Target Recruit Count
- 41
- Registration Number
- NCT00408525
- Locations
- 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States
The Clinical Response of Choline Acetyltransferase and Apolipoprotein Epsilon Gene Polymorphisms to Donepezil in Alzheimer's Disease
- First Posted Date
- 2006-09-27
- Last Posted Date
- 2022-01-04
- Lead Sponsor
- Eisai Korea Inc.
- Target Recruit Count
- 199
- Registration Number
- NCT00381381
- Locations
- 🇰🇷
Seoul National University Bundang Hospital, Bundang, Korea, Republic of
🇰🇷Jeonju City Welfare Hospital, Jeonju, Korea, Republic of
🇰🇷Hallym University Medical Center, Changwon, Korea, Republic of
Functional Brain Imaging of Medication Treatment Response in Mild Alzheimer's Disease Patients
- First Posted Date
- 2006-08-29
- Last Posted Date
- 2013-04-11
- Lead Sponsor
- Duke University
- Target Recruit Count
- 4
- Registration Number
- NCT00369603
- Locations
- 🇺🇸
Joseph & Kathleen Bryan Alzheimer's Disease Research Unit, Durham, North Carolina, United States
Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors
- Conditions
- Interventions
- First Posted Date
- 2006-08-29
- Last Posted Date
- 2021-10-20
- Lead Sponsor
- Wake Forest University Health Sciences
- Target Recruit Count
- 198
- Registration Number
- NCT00369785
- Locations
- 🇺🇸
Gundersen Lutheran Center for Cancer and Blood, La Crosse, Wisconsin, United States
🇺🇸United States Air Force Medical Center - Wright-Patterson, Wright-Patterson Air Force Base, Ohio, United States
🇺🇸Cancer Center of Kansas, PA - Wichita, Wichita, Kansas, United States
The Effect of Donepezil on Sedation and Other Symptoms
- First Posted Date
- 2006-07-14
- Last Posted Date
- 2016-05-09
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 27
- Registration Number
- NCT00352664
- Locations
- 🇺🇸
U.T. M.D. Anderson Cancer Center, Houston, Texas, United States
SB-742457 And Donepezil In Alzheimer's Disease
- Conditions
- First Posted Date
- 2006-07-04
- Last Posted Date
- 2009-06-02
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 200
- Registration Number
- NCT00348192
- Locations
- 🇬🇧
GSK Investigational Site, West of Scotland Science Park, Glasgow, United Kingdom
The Evaluation of the Efficacy and Safety of Donepezil Hydrochloride in Subjects With Mild Cognitive Impairment (MCI)
- First Posted Date
- 2006-02-17
- Last Posted Date
- 2011-04-01
- Lead Sponsor
- Eisai Inc.
- Target Recruit Count
- 821
- Registration Number
- NCT00293176
Drug Development Updates
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