Donepezil

Generic Name
Donepezil
Brand Names
Adlarity, Aricept, Namzaric
Drug Type
Small Molecule
Chemical Formula
C24H29NO3
CAS Number
120014-06-4
Unique Ingredient Identifier
8SSC91326P
Background

In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and in some cases, is used to manage other ty...

Indication

Donepezil, administered orally or via transdermal delivery system, is indicated for the treatment of dementia of the Alzheimer's type. It is also available as an extended-release capsule in combination with memantine for the treatment of moderate-to-severe dementia of the Alzheimer's type in patients previously stabilized on 10mg of donepezil hydrochloride o...

Associated Conditions
Alzheimer's Disease (AD), Dementia With Lewy Body Disease, Dementia due to Parkinson's disease, Dementia of the Alzheimer's Type, Vascular Dementia (VaD), Moderate Alzheimer's Type Dementia, Severe Alzheimer's Type Dementia
Associated Therapies
-
Clinical Trials
Related News

Single-ascending Dose Phase 1 Clinical Trial to Evaluate the Safety and PK of DA-5207 TDS in Healthy Adults

Phase 1
Completed
Conditions
Healthy
Interventions
Drug: DA-5207
Drug: Donepezil Hydrochloride
First Posted Date
2019-07-09
Last Posted Date
2021-04-14
Lead Sponsor
Dong-A ST Co., Ltd.
Target Recruit Count
40
Registration Number
NCT04013477
Locations
🇰🇷

Clinical Trials Center, Severance Hospital, Seoul, Korea, Republic of

The Effect of Donepezil in Radiotherapy-related Cognitive Impairment.

First Posted Date
2019-04-09
Last Posted Date
2019-11-25
Lead Sponsor
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Target Recruit Count
238
Registration Number
NCT03907371
Locations
🇨🇳

Sun Yat-Sen Memorial Hospital, Guangzhou, Guangdong, China

A Study in Healthy Men and Women to Test Which Effects Donepezil and BI 425809 Have on Each Other

Phase 1
Completed
Conditions
Healthy
Interventions
Drug: BI 425809
Drug: Donepezil
First Posted Date
2019-04-05
Last Posted Date
2021-02-17
Lead Sponsor
Boehringer Ingelheim
Target Recruit Count
32
Registration Number
NCT03905096
Locations
🇩🇪

CRS Clinical Research Services Mannheim GmbH, Mannheim, Germany

Clinical Evaluation on the Therapeutic Effect of Acupuncture Treatment for Alzheimer's Disease

Not Applicable
Recruiting
Conditions
Cognitive Impairment
Alzheimer Disease
Interventions
Other: Acupuncture
Drug: Donepezil
First Posted Date
2019-01-22
Last Posted Date
2023-12-12
Lead Sponsor
Shanghai University of Traditional Chinese Medicine
Target Recruit Count
180
Registration Number
NCT03810794
Locations
🇨🇳

LongHua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, Shanghai, China

🇨🇳

Shanghai Mental Center, Shanghai Jiaotong University of Medicial School, Shanghai, Shanghai, China

🇨🇳

Huashan Hospital Fudan University, Shanghai, Shanghai, China

A Pharmacodynamics, Safety, and Pharmacokinetics Study of THN201 Versus Donepezil in Healthy Male Volunteers

First Posted Date
2018-10-09
Last Posted Date
2020-01-22
Lead Sponsor
Theranexus
Target Recruit Count
152
Registration Number
NCT03698695
Locations
🇫🇷

CHU Grenoble, Grenoble, France

🇫🇷

CHU Bordeaux, Bordeaux, France

🇫🇷

CHU Clermont Ferrand, Clermont-Ferrand, France

and more 4 locations

Improving Walking Automaticity in Parkinson's Disease: Levodopa or Donepezil

Early Phase 1
Completed
Conditions
Parkinson Disease
Interventions
Drug: Placebo
Drug: Donepezil
First Posted Date
2018-07-26
Last Posted Date
2020-05-11
Lead Sponsor
Oregon Health and Science University
Target Recruit Count
20
Registration Number
NCT03599726
Locations
🇺🇸

Oregon Health & Science University, Portland, Oregon, United States

A FDG-PET Study of AGN-242071 Added to Standard-of-Care (Donepezil ± Memantine) for the Treatment of Participants With Mild to Moderate Alzheimer's Disease

First Posted Date
2017-10-20
Last Posted Date
2018-11-02
Lead Sponsor
Allergan
Registration Number
NCT03316898
Locations
🇺🇸

Synergy Research Centers, Lemon Grove, California, United States

🇺🇸

Collaborative Neuroscience, Long Beach, California, United States

🇺🇸

Alliance Research, Long Beach, California, United States

and more 3 locations

Octohydroaminoacridine Succinate Tablet for Mild-to-Moderate Alzheimer's Disease

First Posted Date
2017-09-14
Last Posted Date
2019-10-22
Lead Sponsor
Shanghai Mental Health Center
Target Recruit Count
600
Registration Number
NCT03283059
Locations
🇨🇳

Shanghai Mental Health Center, Shanghai, Shanghai, China

A Bioequivalence Study of Corplex™ Donepezil Transdermal Delivery System Compared to Aricept®

Phase 1
Completed
Conditions
Alzheimer's Disease
Interventions
Drug: Donepezil TDS
Drug: Aricept
First Posted Date
2017-08-24
Last Posted Date
2018-08-01
Lead Sponsor
Corium, Inc.
Target Recruit Count
86
Registration Number
NCT03259958
Locations
🇺🇸

Celerion Inc., Phoenix, Arizona, United States

A Based on PEEG and PET Study of Anxiolytic Treatment to Improve Cognitive Function in Patients With Alzheimer Disease

First Posted Date
2017-05-12
Last Posted Date
2017-05-12
Lead Sponsor
Zhejiang Provincial People's Hospital
Target Recruit Count
30
Registration Number
NCT03151382
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