Donepezil
- Generic Name
- Donepezil
- Brand Names
- Adlarity, Aricept, Namzaric
- Drug Type
- Small Molecule
- Chemical Formula
- C24H29NO3
- CAS Number
- 120014-06-4
- Unique Ingredient Identifier
- 8SSC91326P
- Background
In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and in some cases, is used to manage other ty...
- Indication
Donepezil, administered orally or via transdermal delivery system, is indicated for the treatment of dementia of the Alzheimer's type. It is also available as an extended-release capsule in combination with memantine for the treatment of moderate-to-severe dementia of the Alzheimer's type in patients previously stabilized on 10mg of donepezil hydrochloride o...
- Associated Conditions
- Alzheimer's Disease (AD), Dementia With Lewy Body Disease, Dementia due to Parkinson's disease, Dementia of the Alzheimer's Type, Vascular Dementia (VaD), Moderate Alzheimer's Type Dementia, Severe Alzheimer's Type Dementia
- Associated Therapies
- -
Combining Donepezil With Perceptual Learning in Normal and Amblyopic Human The Effect of Donepezil on Perceptual Learning in Adult Amblyopia
- Conditions
- Interventions
- First Posted Date
- 2017-04-12
- Last Posted Date
- 2019-01-17
- Lead Sponsor
- Dennis Levi
- Target Recruit Count
- 20
- Registration Number
- NCT03109314
- Locations
- 🇺🇸
University of California, Berkeley, Berkeley, California, United States
Clinical Efficacy of Ginkgo Biloba Extract in the Treatment of Alzheimer's Disease
- Conditions
- Interventions
- First Posted Date
- 2017-03-24
- Last Posted Date
- 2019-08-07
- Target Recruit Count
- 240
- Registration Number
- NCT03090516
- Locations
- 🇨🇳
Ting Wu, Nanjing, Jiangsu, China
Detecting an Early Response to Donepezil With Measures of Visual Attention
- First Posted Date
- 2017-03-08
- Last Posted Date
- 2021-02-04
- Lead Sponsor
- NYU Langone Health
- Target Recruit Count
- 25
- Registration Number
- NCT03073876
- Locations
- 🇺🇸
Winthrop-University Hospital, Mineola, New York, United States
Study of DHP1401 in Patients With Mild-moderate Alzheimer's Disease Treated With Donepezil(DRAMA)
- Conditions
- Interventions
- First Posted Date
- 2017-02-16
- Last Posted Date
- 2019-08-20
- Lead Sponsor
- Daehwa Pharmaceutical Co., Ltd.
- Target Recruit Count
- 180
- Registration Number
- NCT03055741
- Locations
- 🇰🇷
Chonnam National University Hospital, Gwangju-si, Jeollanam-do, Korea, Republic of
🇰🇷The Catholic University of Korea, Bucheon, ST. Mary's Hospital, Bucheon-si, Gyeonggi-do, Korea, Republic of
🇰🇷Myongji Hospital, Goyang-si, Gyeonggi-do, Korea, Republic of
Study to Evaluate the Effects of BPN14770 on Scopolamine-induced Cognitive Impairment in Healthy Volunteers
- Conditions
- Interventions
- First Posted Date
- 2017-01-24
- Last Posted Date
- 2018-10-16
- Lead Sponsor
- Tetra Discovery Partners
- Target Recruit Count
- 38
- Registration Number
- NCT03030105
- Locations
- 🇺🇸
ICON Early Phase Services, LLC, Austin, Texas, United States
Effect of Acetylcholinesterase Inhibitors on the Gait of the Patients With Parkinson Disease
- First Posted Date
- 2017-01-05
- Last Posted Date
- 2018-03-07
- Lead Sponsor
- Kyung Hee University Hospital
- Target Recruit Count
- 20
- Registration Number
- NCT03011476
- Locations
- 🇰🇷
Kyung Hee Universtiy Hospital, Seoul, Korea, Republic of
Memory and Mental Health in Aging
- First Posted Date
- 2016-12-09
- Last Posted Date
- 2017-02-10
- Lead Sponsor
- Stanford University
- Target Recruit Count
- 198
- Registration Number
- NCT02988908
- Locations
- 🇺🇸
VA Palo Alto Health Care System, Palo Alto, California, United States
A Phase 1, Corplex™ Donepezil Transdermal System Compared to Oral Aricept®
- Conditions
- Interventions
- First Posted Date
- 2016-11-21
- Last Posted Date
- 2018-08-01
- Lead Sponsor
- Corium, Inc.
- Target Recruit Count
- 107
- Registration Number
- NCT02968719
- Locations
- 🇺🇸
Celerion, Phoenix, Arizona, United States
Donepezil Attenuate Postoperative Cognitive Dysfunction
- Conditions
- Interventions
- First Posted Date
- 2016-10-07
- Last Posted Date
- 2020-01-30
- Lead Sponsor
- RenJi Hospital
- Target Recruit Count
- 550
- Registration Number
- NCT02927522
- Locations
- 🇨🇳
Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, Shanghai, China
TAK-071 Scopolamine-Induced Cognitive Impairment Study
- Conditions
- Interventions
- First Posted Date
- 2016-09-28
- Last Posted Date
- 2019-06-14
- Lead Sponsor
- Takeda
- Target Recruit Count
- 18
- Registration Number
- NCT02918266
Drug Development Updates
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