Brensocatib
- Generic Name
- Brensocatib
- Drug Type
- Small Molecule
- Chemical Formula
- C23H24N4O4
- CAS Number
- 1802148-05-5
- Unique Ingredient Identifier
- 25CG88L0BB
- Background
Brensocatib is under investigation in clinical trial NCT03218917 (Assessment of INS1007 in Subjects With Non-cystic Fibrosis Bronchiectasis).
- Indication
用于非囊性纤维化支气管扩张症（NCFBE）成人患者的治疗。
A Study of the Efficacy and Safety of Brensocatib in Adults With Moderate to Severe Hidradenitis Suppurativa (HS)
- First Posted Date
- 2024-11-13
- Last Posted Date
- 2025-05-18
- Lead Sponsor
- Insmed Incorporated
- Target Recruit Count
- 204
- Registration Number
- NCT06685835
- Locations
- 🇺🇸
USA007, Sacramento, California, United States
🇺🇸USA026, Coral Gables, Florida, United States
🇺🇸USA021, Margate, Florida, United States
A Study to Assess the Relative Bioavailability of Brensocatib Pediatric Oral Solution to Oral Tablets in Healthy Participants
- Conditions
- Healthy Participants
- Interventions
- First Posted Date
- 2024-04-03
- Last Posted Date
- 2024-06-13
- Lead Sponsor
- Insmed Incorporated
- Target Recruit Count
- 24
- Registration Number
- NCT06344728
- Locations
- 🇺🇸
USA001, Dallas, Texas, United States
A Study of the Palatability and Acceptability of Different Brensocatib Oral Liquid Formulations in Healthy Participants
- First Posted Date
- 2023-12-21
- Last Posted Date
- 2024-01-22
- Lead Sponsor
- Insmed Incorporated
- Target Recruit Count
- 20
- Registration Number
- NCT06178783
- Locations
- 🇺🇸
USA001, Dallas, Texas, United States
A Study of the Efficacy and Safety of Brensocatib in Participants With Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)
- Conditions
- Chronic Rhinosinusitis Without Nasal Polyps
- Interventions
- First Posted Date
- 2023-08-28
- Last Posted Date
- 2025-05-11
- Lead Sponsor
- Insmed Incorporated
- Target Recruit Count
- 288
- Registration Number
- NCT06013241
- Locations
- 🇺🇸
USA004, Tulsa, Oklahoma, United States
🇦🇷ARG004, Rosario, Santa Fe, Argentina
🇦🇷ARG014, Mendoza, Argentina
A Study to Investigate Effect of Clarithromycin, a Strong CYP3A4 Inhibitor, on Brensocatib Pharmacokinetics in Healthy Participants
- First Posted Date
- 2023-07-28
- Last Posted Date
- 2023-12-11
- Lead Sponsor
- Insmed Incorporated
- Target Recruit Count
- 22
- Registration Number
- NCT05965570
- Locations
- 🇺🇸
USA001, Dallas, Texas, United States
A Study of the Safety, Pharmacokinetics, and Pharmacodynamics of INS1007 in Healthy Japanese and Caucasian Participants
- First Posted Date
- 2023-07-03
- Last Posted Date
- 2023-07-03
- Lead Sponsor
- Insmed Incorporated
- Target Recruit Count
- 82
- Registration Number
- NCT05927597
- Locations
- 🇺🇸
USA001, Glendale, California, United States
A Study to Assess Pharmacokinetics (PK) of Brensocatib Alone and With Multiple Doses of Rifampin or Esomeprozole in Healthy Participants
- Conditions
- Healthy Volunteers
- Interventions
- First Posted Date
- 2023-04-24
- Last Posted Date
- 2023-08-21
- Lead Sponsor
- Insmed Incorporated
- Target Recruit Count
- 32
- Registration Number
- NCT05826574
- Locations
- 🇺🇸
USA001, Dallas, Texas, United States
A Study of Brensocatib Following a Single Oral Administration in Participants With or Without Renal Impairment
- First Posted Date
- 2023-01-06
- Last Posted Date
- 2023-04-18
- Lead Sponsor
- Insmed Incorporated
- Target Recruit Count
- 28
- Registration Number
- NCT05673603
- Locations
- 🇺🇸
USA003, Tampa, Florida, United States
🇺🇸USA001, San Antonio, Texas, United States
🇺🇸USA002, Orlando, Florida, United States
A Study to Evaluate the Pharmacokinetics (PK) and Safety of a Single Dose of Brensocatib in Participants With Normal Hepatic Function and Participants With Hepatic Impairment
- First Posted Date
- 2022-08-26
- Last Posted Date
- 2023-07-19
- Lead Sponsor
- Insmed Incorporated
- Target Recruit Count
- 30
- Registration Number
- NCT05517525
- Locations
- 🇺🇸
USA002, Rialto, California, United States
🇺🇸USA003, Orlando, Florida, United States
🇺🇸USA001, San Antonio, Texas, United States
A Study to Investigate the Effects of Brensocatib on QT Interval in Healthy Participants
- Conditions
- Healthy Volunteer
- Interventions
- First Posted Date
- 2022-05-02
- Last Posted Date
- 2023-03-27
- Lead Sponsor
- Insmed Incorporated
- Target Recruit Count
- 48
- Registration Number
- NCT05355935
- Locations
- 🇺🇸
USA001, Madison, Wisconsin, United States
Drug Development Updates
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