Doxycycline

Generic Name: Doxycycline

Brand Names: Acticlate, Adoxa, Apprilon, Atridox, Doryx, Doxy, Doxycin, Lymepak, Mondoxyne, Monodox, Morgidox, Okebo, Oracea, Periostat, Targadox, Vibramycin

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₄N_₂O_₈

CAS Number: 564-25-0

Unique Ingredient Identifier: 334895S862

Background: Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and gram-negative bacterial infections. It is also used to treat acne and malaria.

Indication: Doxycycline is indicated for the treatment of various infections by gram-positive and gram-negative bacteria, aerobes and anaerobes, as well other types of bacteria, including:

It is also used to treat infections caused by the following gram-negative microorganisms:

Associated Conditions: Acinetobacter Infections, Anthrax, Bacterial Infection caused by Enterobacter aerogenes, Bartonellosis, Brucellosis, Campylobacter Infection, Chancroid, Chlamydia Trachomatis Infection, Early Lyme Disease, Granuloma Inguinale, Infection Due to Escherichia Coli, Inhalational Anthrax, Klebsiella Infections, Lymphogranuloma Venereum, Malaria caused by Plasmodium falciparum, Nongonococcal urethritis, Plague caused by Yersinia pestis, Psittacosis, Rectal infection caused by Chlamydia Trachomatis, Relapsing fever caused by Borrelia recurrentis, Respiratory Tract Infection Bacterial, Rickettsial infectious disorders, Severe Acne, Sexually Transmitted Infections (STIs), Shigella Infection, Trachoma inclusion conjunctivitis, Tularemia, Vibrio Cholerae Infection, Acute Intestinal amebiasis, Susceptible Bacterial Infections, Uncomplicated endocervical infection, Uncomplicated urethral infection

Associated Therapies: -

Clinical Trials

Doxycycline- and Furazolidone-containing Quadruple Regimen is Superior of Tailored Therapy

Phase 4

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Doxycycline
Drug: Esomeprazole
Drug: Furazolidone
Drug: Sensitivity antibiotics
Drug: Colloidal Bismuth Subcitrate

First Posted Date: 2016-09-09

Last Posted Date: 2018-09-05

Lead Sponsor: Sir Run Run Shaw Hospital

Target Recruit Count: 300

Registration Number: NCT02894268

Locations: 🇨🇳
Sir Run Run Shaw Hospital,Zhejiang University, Hangzhou, Zhejiang, China

Levofloxacin-Doxycycline for Helicobacter Pylori Eradication in Saudi Arabia

Not Applicable

Completed

Conditions: GASTRITIS

Interventions: Drug: Levofloxacin
Drug: Doxycycline
Drug: Esomeprazole

First Posted Date: 2016-08-31

Last Posted Date: 2016-08-31

Lead Sponsor: King Faisal Specialist Hospital & Research Center

Target Recruit Count: 55

Registration Number: NCT02884713

Metformin Hydrochloride and Doxycycline in Treating Patients With Localized Breast or Uterine Cancer

Phase 2

Active, not recruiting

Conditions: Breast Carcinoma
Endometrial Clear Cell Adenocarcinoma
Uterine Corpus Cancer
Endometrial Serous Adenocarcinoma
Uterine Corpus Carcinosarcoma

Interventions: Drug: Metformin Hydrochloride
Drug: Doxycycline

First Posted Date: 2016-08-22

Last Posted Date: 2022-12-15

Lead Sponsor: Sidney Kimmel Cancer Center at Thomas Jefferson University

Target Recruit Count: 27

Registration Number: NCT02874430

Locations: 🇺🇸
Thomas Jefferson University, Philadelphia, Pennsylvania, United States

Oral Doxycycline for the Prevention of Syphilis in Men Who Have Sex With Men (DaDHS)

Phase 4

Active, not recruiting

Conditions: Sexually Transmitted Infections
Syphilis

Interventions: Other: Placebo
Drug: Doxycycline

First Posted Date: 2016-08-12

Last Posted Date: 2024-08-02

Lead Sponsor: British Columbia Centre for Disease Control

Target Recruit Count: 52

Registration Number: NCT02864550

Locations: 🇨🇦
British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada

Doxycycline for the Treatment of Nodding Syndrome

Phase 2

Conditions: Seizures

Interventions: Other: Placebo
Drug: Doxycycline

First Posted Date: 2016-08-01

Last Posted Date: 2017-02-23

Lead Sponsor: Makerere University

Target Recruit Count: 230

Registration Number: NCT02850913

Locations: 🇺🇬
Makerere University College of Health Sciences, Kampala, Uganda

Efficacy of Doxycycline on Metakaryote Cell Death in Patients With Resectable Pancreatic Cancer

Phase 2

Completed

Conditions: Resectable Pancreatic Cancer

Interventions: Drug: Doxycycline

First Posted Date: 2016-05-18

Last Posted Date: 2023-07-03

Lead Sponsor: Medical College of Wisconsin

Target Recruit Count: 12

Registration Number: NCT02775695

Locations: 🇺🇸
Medical College of Wisconsin, Milwaukee, Wisconsin, United States

Doxycycline in Human Pulmonary Tuberculosis

Phase 2

Completed

Conditions: Tuberculosis

Interventions: Drug: placebo
Drug: Doxycycline

First Posted Date: 2016-05-17

Last Posted Date: 2017-11-27

Lead Sponsor: National University Hospital, Singapore

Target Recruit Count: 40

Registration Number: NCT02774993

Locations: 🇸🇬
National University Hospital, Singapore, Singapore

A Randomized Controlled Trial of Three Antibiotic Regimens for First Trimester Abortions

Not Applicable

Completed

Conditions: First Trimester Abortion

Interventions: Drug: Doxycycline
Drug: Metronidazole
Drug: Azithromycin
Drug: Placebo

First Posted Date: 2016-04-29

Last Posted Date: 2022-02-11

Lead Sponsor: Medstar Health Research Institute

Target Recruit Count: 181

Registration Number: NCT02756403

Locations: 🇺🇸
MedStar Washington Hospital Center, Washington, District of Columbia, United States
🇺🇸
Planned Parenthood Metropolitan Washington, Silver Spring, Maryland, United States