Demeclocycline

Background: A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.

Indication: Used primarily to treat Lyme disease, acne, and bronchitis. Also indicated (but rarely used) to treat urinary tract infections, gum disease, malaria, and other bacterial infections such as gonorrhea and chlamydia. One of its other registered uses is the treatment of hyponatremia (low blood sodium concentration) due to the syndrome of inappropriate antidiuretic hormone (SIADH) where fluid restriction alone has been ineffective.

Associated Conditions: Relapsing fever caused by Borrelia recurrentis, Tularemia, Severe Acne Vulgaris, Psittacosis, Urinary Tract Infection, Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH), Acute Intestinal amebiasis, Conjunctivitis caused by chlamydia, Yaws, Campylobacter Infection, Rickettsia Infections, Anthrax, Listeria infection, Skin Infections caused by Staphylococcus Aureus, Chlamydial Infections, Clostridium Difficile Infection (CDI), Brucellosis, Bartonellosis, Chlamydia Trachomatis Infection, Gram-Negative Bacterial Infections, Plague, Actinomycosis, Sexually Transmitted Infections (STIs), Cholera (Disorder), Necrotizing ulcerative gingivostomatitis, Respiratory Tract Infections (RTI)

Demeclocycline Fluorescence for Intraoperative Delineation Brain Tumors

Phase 1

Locations: 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States

Phase 4

Completed

Interventions: Drug: Teriparatide
Drug: Denosumab
Drug: Demeclocycline
Drug: Tetracycline
Drug: Calcium Supplement
Drug: Vitamin D

Locations: 🇨🇦
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Sainte-Foy, Quebec, Canada

Withdrawn

Locations: 🇺🇸
University Cancer Center at University of Washington Medical Center, Seattle, Washington, United States

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