Diflunisal
- Generic Name
- Diflunisal
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C13H8F2O3
- CAS Number
- 22494-42-4
- Unique Ingredient Identifier
- 7C546U4DEN
- Background
Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear to be associated with inhibition of prostaglandin synthesis via the arachidonic acid pathway. Diflunisal is used to relieve pain accompanied with inflammation and in the symptomatic treatment of rheumatoid arthritis and osteoarthritis.
- Indication
For symptomatic treatment of mild to moderate pain accompanied by inflammation (e.g. musculoskeletal trauma, post-dental extraction, post-episiotomy), osteoarthritis, and rheumatoid arthritis.
- Associated Conditions
- Mild pain, Osteoarthritis (OA), Rheumatoid Arthritis, Moderate Pain
- Associated Therapies
- -
The Effects Diflunisal on the Levels of BMS-986165 in Healthy Participants
- First Posted Date
- 2019-10-03
- Last Posted Date
- 2020-08-05
- Lead Sponsor
- Bristol-Myers Squibb
- Target Recruit Count
- 48
- Registration Number
- NCT04113668
- Locations
- 🇺🇸
PRA Health Sciences - Lenexa, Lenexa, Kansas, United States
Pilot Study of Diflunisal in HIV-infected Adults
- First Posted Date
- 2012-08-30
- Last Posted Date
- 2017-10-27
- Lead Sponsor
- University of British Columbia
- Target Recruit Count
- 8
- Registration Number
- NCT01676363
- Locations
- 🇨🇦
Immunodeficiency Clinic, St. Paul's Hospital, Vancouver, British Columbia, Canada
The Effect of Diflunisal on Familial Transthyretin Amyloidosis
- Conditions
- First Posted Date
- 2011-09-13
- Last Posted Date
- 2015-08-24
- Lead Sponsor
- Umeå University
- Target Recruit Count
- 55
- Registration Number
- NCT01432587
- Locations
- 🇸🇪
Dept of Clinical Medicin, Ptieå Hospital, Piteå, Sweden
🇸🇪Dept of Clinical Medicine, Umeå University Hospital, Umeå, Sweden
🇸🇪Dept of clinical medicin, Skellefteå Hospital, Skellefteå, Sweden
The Effect of Diflunisal on Familial Amyloidosis
- Conditions
- Interventions
- First Posted Date
- 2006-02-22
- Last Posted Date
- 2017-03-17
- Lead Sponsor
- Boston University
- Target Recruit Count
- 130
- Registration Number
- NCT00294671
- Locations
- 🇯🇵
Kumamoto University, Kumamoto, Japan
🇺🇸Mount Sinai School of Medicine, Department of Medicine, New York, New York, United States
🇮🇹IRCCS Policlinico San Matteo, Pavia, Italy
Drug Development Updates
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