Idebenone
- Generic Name
- Idebenone
- Brand Names
- Raxone
- Drug Type
- Small Molecule
- Chemical Formula
- C19H30O5
- CAS Number
- 58186-27-9
- Unique Ingredient Identifier
- HB6PN45W4J
- Background
Idebenone is a synthetic analogue of ubiquinone (also known as Coenzyme Q10), a vital cell antioxidant and essential component of the Electron Transport Chain (ETC). It has been proposed that by interacting with the ETC, idebenone increases ATP production required for mitochondrial function, reduces free radicals, inhibits lipid peroxidation, and consequentl...
- Indication
Idebenone is indicated for use by the European Medicines Agency (EMA) for the treatment of visual impairment in adolescent and adult patients with
Leber’s Hereditary Optic Neuropathy (LHON). It is not currently approved for use by either the Food and Drug Administration (USA) or Health Canada .
- Associated Conditions
- Alzheimer's Disease (AD), Leber’s hereditary optic neuropathy
- Associated Therapies
- -
Efficacy and Tolerability of Idebenone in Boys With Cardiac Dysfunction Associated With Duchenne Muscular Dystrophy
- Conditions
- Interventions
- First Posted Date
- 2008-04-09
- Last Posted Date
- 2011-08-01
- Lead Sponsor
- Santhera Pharmaceuticals
- Target Recruit Count
- 21
- Registration Number
- NCT00654784
- Locations
- 🇧🇪
Children's Hospital, University Hospital, Leuven, Belgium
Study to Assess the Efficacy, Safety and Tolerability of Idebenone in the Treatment of Friedreich's Ataxia
- First Posted Date
- 2007-10-01
- Last Posted Date
- 2023-07-11
- Lead Sponsor
- Santhera Pharmaceuticals
- Target Recruit Count
- 70
- Registration Number
- NCT00537680
- Locations
- 🇺🇸
David Geffen School of Medicine, UCLA, Los Angeles, California, United States
🇺🇸The Children's Hopsital of Philadelphia, Philadelphia, Pennsylvania, United States
Idebenone to Treat Friedreich's Ataxia
- Conditions
- First Posted Date
- 2005-09-29
- Last Posted Date
- 2019-03-18
- Target Recruit Count
- 51
- Registration Number
- NCT00229632
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
Phase 1 Trial of Idebenone to Treat Patients With Friedreich's Ataxia
- Conditions
- First Posted Date
- 2004-03-01
- Last Posted Date
- 2008-03-04
- Target Recruit Count
- 16
- Registration Number
- NCT00078481
- Locations
- 🇺🇸
National Institute of Neurological Disorders and Stroke (NINDS), Bethesda, Maryland, United States
Safety Study of Idebenone to Treat Friedreich's Ataxia
- Conditions
- First Posted Date
- 2001-05-07
- Last Posted Date
- 2006-07-12
- Target Recruit Count
- 100
- Registration Number
- NCT00015808
- Locations
- 🇺🇸
National Institute of Neurological Disorders and Stroke (NINDS), Bethesda, Maryland, United States
Drug Development Updates
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