Chlorzoxazone
- Generic Name
- Chlorzoxazone
- Brand Names
- Lorzone, Parafon Forte
- Drug Type
- Small Molecule
- Chemical Formula
- C7H4ClNO2
- CAS Number
- 95-25-0
- Unique Ingredient Identifier
- H0DE420U8G
- Background
A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202)
- Indication
For the relief of discomfort associated with acute painful musculoskeletal conditions.
- Associated Conditions
- Acute painful musculoskeletal conditions
Pharmacokinetic and Bioequivalence Comparison of Baclofen and Chlorzoxazone Administered Individually or Concurrently
- Conditions
- Pharmacokinetics
- Interventions
- First Posted Date
- 2022-02-25
- Last Posted Date
- 2023-03-31
- Lead Sponsor
- University of Texas Southwestern Medical Center
- Target Recruit Count
- 19
- Registration Number
- NCT05257447
- Locations
- 🇺🇸
UT Southwestern Medical Center, Dallas, Texas, United States
A Study to Investigate the Potential Influence of Nitisinone on the Metabolism and the Transport of Other Drugs in Healthy Volunteers
- Conditions
- Drug Drug Interaction
- Interventions
- First Posted Date
- 2017-04-06
- Last Posted Date
- 2017-08-10
- Lead Sponsor
- Swedish Orphan Biovitrum
- Target Recruit Count
- 36
- Registration Number
- NCT03103568
- Locations
- 🇩🇪
PAREXEL EPCU Berlin, Berlin, Germany
Chlorzoxazone in Hip and Knee Arthroplasty
- Conditions
- Osteoarthritis of HipOsteoarthritis, Knee
- Interventions
- First Posted Date
- 2015-04-01
- Last Posted Date
- 2019-09-09
- Lead Sponsor
- Northern Orthopaedic Division, Denmark
- Target Recruit Count
- 400
- Registration Number
- NCT02405104
- Locations
- 🇩🇰
Northern Orthopaedic Division, Clinic Farsø, Aalborg University Hospital, Farsø, Northern Jutland, Denmark
The Effect of Chlorzoxazone on Moderate to Severe Postoperative Pain After Spine Surgery
- Conditions
- ChlorzoxazonePostoperative Pain
- Interventions
- First Posted Date
- 2013-09-02
- Last Posted Date
- 2015-09-17
- Lead Sponsor
- Rigshospitalet, Denmark
- Target Recruit Count
- 110
- Registration Number
- NCT01933542
- Locations
- 🇩🇰
Glostrup University Hospital, Glostrup, Denmark
Placebo-Controlled Cross Over Trial of Chlorzoxazone Intake
- First Posted Date
- 2011-04-27
- Last Posted Date
- 2020-11-20
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 48
- Registration Number
- NCT01342341
- Locations
- 🇺🇸
Ernest Gallo Clinic and Research Center, Emeryville, California, United States
Pharmacokinetic Study to Investigate Low-dose Combinations of a Cocktail of Seven Drugs for Simultaneous Phenotyping of Cytochromes
- Conditions
- CytochromePharmacokinetics
- Interventions
- First Posted Date
- 2010-08-24
- Last Posted Date
- 2015-04-17
- Lead Sponsor
- University Hospital, Basel, Switzerland
- Target Recruit Count
- 16
- Registration Number
- NCT01187862
- Locations
- 🇨🇭
University Hospital, Basel, Switzerland
Drug Development Updates
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