Ranolazine
- Generic Name
- Ranolazine
- Brand Names
- Aspruzyo Sprinkle, Ranexa, Ranexa (previously Latixa)
- Drug Type
- Small Molecule
- Chemical Formula
- C24H33N3O4
- CAS Number
- 95635-55-5
- Unique Ingredient Identifier
- A6IEZ5M406
- Background
Chronic angina is a common cardiovascular condition affecting millions worldwide and causes significant disability while interfering with daily activities. Ranolazine is a well-tolerated piperazine derivative used for the management of this condition, offering relief from uncomfortable and debilitating symptoms. With a mechanism of action different from drug...
- Indication
Ranolazine is indicated for the treatment of chronic angina. It can be used alone or in conjunction with nitrates, beta-blockers, angiotensin receptor blockers, anti-platelet drugs, calcium channel blockers, lipid-lowering drugs, and ACE inhibitors.
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- Associated Conditions
- Chronic Angina, Ventricular Arrhythmia
- Associated Therapies
- -
Ranolazine for Improving Symptoms of Palpitations
- First Posted Date
- 2011-12-20
- Last Posted Date
- 2013-03-07
- Lead Sponsor
- University of Roma La Sapienza
- Target Recruit Count
- 100
- Registration Number
- NCT01495520
Ranolazine When Added to Glimepiride in Subjects With Type 2 Diabetes Mellitus
- Conditions
- Interventions
- First Posted Date
- 2011-12-19
- Last Posted Date
- 2014-11-18
- Lead Sponsor
- Gilead Sciences
- Target Recruit Count
- 431
- Registration Number
- NCT01494987
- Locations
- 🇺🇸
Clinical Research Advantage/Desert Clinical Research, LLC, Mesa, Arizona, United States
🇺🇸Desert Sun Clinical Research, LLC, Tucson, Arizona, United States
🇺🇸Southland Clinical Research Center, Inc., Fountain Valley, California, United States
Ranolazine Loading to Prevent PCI-induced Myocardial Injury
- First Posted Date
- 2011-12-13
- Last Posted Date
- 2013-03-07
- Lead Sponsor
- University of Roma La Sapienza
- Target Recruit Count
- 100
- Registration Number
- NCT01491061
- Locations
- 🇮🇹
San Raffaele Pisana, Rome, Italy
Pharmacodynamic Effects of Ranolazine Versus Amlodipine on Platelet Reactivity
- First Posted Date
- 2011-12-12
- Last Posted Date
- 2014-03-26
- Lead Sponsor
- University of Roma La Sapienza
- Target Recruit Count
- 100
- Registration Number
- NCT01490255
- Locations
- 🇮🇹
San Raffaele Pisana, Rome, Italy
🇮🇹University La Sapienza, Rome, Italy
Ranolazine Monotherapy in Subjects With Type 2 Diabetes Mellitus
- Conditions
- Interventions
- First Posted Date
- 2011-11-16
- Last Posted Date
- 2014-10-24
- Lead Sponsor
- Gilead Sciences
- Target Recruit Count
- 465
- Registration Number
- NCT01472185
- Locations
- 🇺🇸
Thunderbird Internal Medicine/Clinical Research Advantage, Glendale, Arizona, United States
🇺🇸North Central Arkansas Medical Associates, Mountain Home, Arkansas, United States
🇺🇸Desert Sun Clinical Research, LLC, Tucson, Arizona, United States
Ranolazine for Incomplete Vessel Revascularization Post-Percutaneous Coronary Intervention (PCI)
- Conditions
- Interventions
- First Posted Date
- 2011-09-28
- Last Posted Date
- 2016-07-15
- Lead Sponsor
- Gilead Sciences
- Target Recruit Count
- 2651
- Registration Number
- NCT01442038
- Locations
- 🇺🇸
Tallahassee Research Institute, Tallahassee, Florida, United States
🇺🇸Union Memorial Hospital, Baltimore, Maryland, United States
🇺🇸Veterans Administration Medical Center, Pittsburgh, Pennsylvania, United States
Pharmacokinetics of Single-Dose Oral Ranolazine in Hemodialysis Patients
- Conditions
- Interventions
- First Posted Date
- 2011-09-16
- Last Posted Date
- 2017-10-16
- Lead Sponsor
- University of Michigan
- Target Recruit Count
- 17
- Registration Number
- NCT01435174
- Locations
- 🇺🇸
University of Michigan Hospital, Ann Arbor, Michigan, United States
Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina
- Conditions
- Interventions
- First Posted Date
- 2011-08-30
- Last Posted Date
- 2014-11-04
- Lead Sponsor
- Gilead Sciences
- Target Recruit Count
- 949
- Registration Number
- NCT01425359
- Locations
- 🇷🇺
State Institution of Healthcare Perm Regional Hospital for War Veterans, Perm, Russian Federation
🇺🇸Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, United States
🇺🇸Med-Tech Research, Houston, Texas, United States
Suppression Of Atrial Fibrillation With Ranolazine After Cardiac Surgery
- Conditions
- Interventions
- First Posted Date
- 2011-05-11
- Last Posted Date
- 2017-01-06
- Lead Sponsor
- William Beaumont Hospitals
- Target Recruit Count
- 15
- Registration Number
- NCT01352416
- Locations
- 🇺🇸
William Beaumont Hospital, Troy, Michigan, United States
Ranolazine for the Prevention of Atrial Fibrillation After Electrical Cardioversion
- First Posted Date
- 2011-05-06
- Last Posted Date
- 2017-04-27
- Lead Sponsor
- University of Oklahoma
- Target Recruit Count
- 10
- Registration Number
- NCT01349491
- Locations
- 🇺🇸
OU Medical Center, Oklahoma City, Oklahoma, United States
🇺🇸Oklahoma City VA Medical Center, Oklahoma City, Oklahoma, United States
Drug Development Updates
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