Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC) . It was initially approved in the USA in 1990's for the treatment of NSCLC .
It is a third-generation vinca alkaloid. The introduction of third-generation drugs (vinorelbine, gemcitabine, taxanes) in platinum combination improved survival of patients with advanced NSCLC, with very similar results from the various drugs. Treatment toxicities are considerable in the combination treatment setting .
A study was done on the clearance rate of vinorelbine on individuals with various single polymorphonuclear mutations. It was found that there was 4.3-fold variation in vinorelbine clearance across the cohort, suggesting a strong influence of genetics on the clearance of this drug .
Vinorelbine tartrate is indicated for adults in the treatment of advanced non-small cell lung cancer (NSCLC), as a single therapy or in combination with other chemotherapeutic drugs .
Used in relapsed or refractory Hodgkin lymphoma, in combination with other chemotherapy agents .
For the treatment of desmoid tumor or aggressive fibromatosis, in combination with methotrexate .
For the treatment of recurrent or metastatic squamous cell head and neck cancer .
For the treatment of recurrent ovarian cancer .
For the treatment of metastatic breast cancer, in patients previously treated with anthracyline and/or taxane therapy .
For the treatment of HER2-positive, trastuzumab-resistant, advanced breast cancer in patients previously treated with a taxane, in combination with trastuzumab and everolimus .
Hartford Hospital, Hartford, Connecticut, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
Washington University, Saint Louis, Missouri, United States
Sismanogleio General Hospital, 1st, 2nd Dep of Pulmonary Diseases, Athens, Greece
"Laikon" General Hospital, Medical Oncology Unit, Propedeutic Dep of Internal Medicine, Athens, Greece
IASO" General Hospital of Athens, 1st Dep of Medical Oncology, Athens, Greece
Research Site, Zurich, Switzerland
Centre de Lutte Contre le Cancer Georges-Francois Leclerc, Dijon, France
Centre Oscar Lambret, Lille, France
Institut Curie Hopital, Paris, France
Piedmont Hospital Research Institute, Atlanta, Georgia, United States
Emory University Winship Cancer Institute, Atlanta, Georgia, United States
Leesburg Regional Medical Center, Leesburg, Florida, United States
Center for Cancer Care & Research/Watson, Lakeland, Florida, United States
Johns Hopkins Sidney Kimmell Comprehensive Cancer Center, Baltimore, Maryland, United States
Stanford University School of Medicine, Stanford, California, United States
GSK Investigational Site, Southampton, United Kingdom
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.