Promethazine
- Generic Name
- Promethazine
- Brand Names
- Phenadoz, Phenergan, Promethazine DM, Promethegan
- Drug Type
- Small Molecule
- Chemical Formula
- C17H20N2S
- CAS Number
- 60-87-7
- Unique Ingredient Identifier
- FF28EJQ494
- Background
Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of phenothiazine that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.
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- Indication
Promethazine tablets and suppositories are indicated to treat rhinitis, allergic conjunctivitis, allergic reactions to blood or plasma, dermographism, anaphylactic reactions, sedation, nausea, vomiting, pain, motion sickness, and allergic skin reactions. Promethazine cough syrup with phenylephrine and codeine is indicated to relieve cough and upper respirato...
- Associated Conditions
- Allergic Conjunctivitis (AC), Allergic urticaria, Anaphylaxis, Cough, Dermographism, Motion Sickness, Nasal Congestion, Postoperative pain, Seasonal Allergic Rhinitis, Vasomotor Rhinitis, Acute Allergic Reactions, Dry cough, Perioperative nausea and vomiting, Upper respiratory symptoms
- Associated Therapies
- Sedative therapy, Adjunct to anesthesia and analgesia therapy
Efficacy of Low Dose Promethazine for Postoperative Nausea and Vomiting
- Conditions
- Interventions
- First Posted Date
- 2010-07-09
- Last Posted Date
- 2011-07-27
- Lead Sponsor
- Women's College Hospital
- Target Recruit Count
- 400
- Registration Number
- NCT01159548
- Locations
- 🇨🇦
Women's College Hospital, Toronto, Ontario, Canada
Effects of Oral Midazolam in Comparison Promethazine With Nitrous Oxide for Uncooperative Children
- First Posted Date
- 2010-05-07
- Last Posted Date
- 2010-05-07
- Lead Sponsor
- Shahid Beheshti University
- Target Recruit Count
- 20
- Registration Number
- NCT01118884
- Locations
- 🇮🇷
Dental school of Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic of
Adjunct Sedatives in Endoscopic Ultrasound (EUS) and Endoscopic Retrograde Cholangiopancreatography (ERCP) Procedures
- Conditions
- Interventions
- First Posted Date
- 2009-07-13
- Last Posted Date
- 2024-02-26
- Lead Sponsor
- University of California, Irvine
- Target Recruit Count
- 304
- Registration Number
- NCT00937924
- Locations
- 🇺🇸
H.H. Chao Comprehensive Digestive Disease Center, Orange, California, United States
Comparison of Ondansetron, Metoclopramide and Promethazine for the Treatment of Nausea and Vomiting in the Adult ED
- Conditions
- Interventions
- First Posted Date
- 2008-04-10
- Last Posted Date
- 2013-10-30
- Lead Sponsor
- Vanderbilt University
- Target Recruit Count
- 171
- Registration Number
- NCT00655642
- Locations
- 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States
A RCT of Ondansetron and Promethazine in the Treatment of Nausea and Vomiting in the Emergency Department
- First Posted Date
- 2007-02-01
- Last Posted Date
- 2007-02-01
- Lead Sponsor
- University of New Mexico
- Target Recruit Count
- 120
- Registration Number
- NCT00429832
- Locations
- 🇺🇸
University of New Mexico Hospital Emergency Department, Albuquerque, New Mexico, United States
Drug Development Updates
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