Triptorelin

Generic Name: Triptorelin

Brand Names: Decapeptyl, Trelstar, Triptodur

Drug Type: Small Molecule

Chemical Formula: C_₆₄H_₈₂N_₁₈O_₁₃

CAS Number: 57773-63-4

Unique Ingredient Identifier: 9081Y98W2V

Background: Triptorelin is a synthetic decapeptide agonist analog of luteinizing hormone releasing hormone (LHRH). Possessing greater potency than endogenous LHRH, triptorelin reversibly represses gonadotropin secretion. After chronic, continuous administration, this agent effects sustained decreases in LH and FSH production and testicular and ovarian steroidogenesis. Serum testosterone concentrations may fall to levels typically observed in surgically castrated men.

Indication: Triptorelin is indicated for the palliative treatment of advanced prostate cancer.

Associated Conditions: Advanced Prostate Cancer

Associated Therapies: Controlled ovarian hyperstimulation therapy

Clinical Trials

Dual Trigger to Reduce Ovarian Hyperstimulation Syndrome

Not Applicable

Conditions: Infertility and at High Risk of OHSS

Interventions: Drug: triptorelin
Drug: hCG

First Posted Date: 2013-12-27

Last Posted Date: 2013-12-27

Lead Sponsor: Chenshiling

Target Recruit Count: 200

Registration Number: NCT02022228

Locations: 🇨🇳
Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China

TRial on the Endocrine Activity of Neoadjuvant Degarelix

Phase 2

Completed

Conditions: Breast Cancer Invasive Nos

Interventions: Drug: triptorelin
Drug: degarelix
Drug: letrozole

First Posted Date: 2013-12-09

Last Posted Date: 2019-05-29

Lead Sponsor: ETOP IBCSG Partners Foundation

Target Recruit Count: 51

Registration Number: NCT02005887

Locations: 🇮🇹
Azienda Ospedaliero-Universitaria Policlinico S. Orsola-Malpighi di Bologna, Bologna, Italy
🇮🇹
Istituto Toscana Tumori, Prato, Italy
🇮🇹
Ospedale degli Infermi, Rimini, Italy

and more 4 locations

Evaluation of the Optimal Dose of GnRH Agonist for Triggering Final Oocyte Maturation in High Risk OHSS Patients

Phase 2

Conditions: Subfertility

Interventions: Drug: 0.2 mg triptorelin
Drug: 0.4 mg triptorelin
Drug: 0.1 mg triptorelin

First Posted Date: 2013-11-01

Last Posted Date: 2016-02-12

Lead Sponsor: Aristotle University Of Thessaloniki

Target Recruit Count: 90

Registration Number: NCT01973842

Locations: 🇬🇷
Unit of Human Reproduction, 1st Dept of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
🇬🇷
Eugonia IVF Unit, Athens, Greece

MEdical Versus SUrgical Treatments of Rectal Endometriosis

Phase 3

Conditions: Endometriosis

Interventions: Drug: Triptoreline 11.25 i.v.; Estradiol 0.5% percutaneous gel;
Procedure: rectal shaving; rectal disc excision; colorectal resection
Drug: Cyproterone acetate 50 mg; estradiol 0.5% percutaneous
Drug: Estradiol 0.5% percutaneous gel; Cyproterone acetate 50 mg oral

First Posted Date: 2013-11-01

Last Posted Date: 2017-06-14

Lead Sponsor: University Hospital, Rouen

Target Recruit Count: 78

Registration Number: NCT01973816

Locations: 🇫🇷
CHU de DIJON, Dijon, France
🇫🇷
CHU de STRASBOURG STRASBOURG, Strasbourg, France
🇫🇷
Clinique Gynécologique CHRU de LILLE, Lille, France

and more 8 locations

A Study to Describe the Efficacy of Diphereline Following Conservative Surgery in Deep Infiltrating Endometriosis (DIE) Patients Over a Period of 24 Months

Completed

Conditions: Deep Infiltrating Endometriosis (DIE)

Interventions: Drug: Triptorelin Acetate 3.75mg intramuscular injection

First Posted Date: 2013-09-16

Last Posted Date: 2018-12-06

Lead Sponsor: Ipsen

Target Recruit Count: 402

Registration Number: NCT01942369

Locations: 🇨🇳
Chinese PLA General Hospital, Beijing, China
🇨🇳
Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China
🇨🇳
Shenzhen People's Hospital, Shenzhen, China

and more 15 locations

GnRH Agonist Pretreatment in Hysteroscopic Myomectomy

Not Applicable

Completed

Conditions: Uterine Myoma

Interventions: Drug: Triptorelin 3.75 mg

First Posted Date: 2013-06-10

Last Posted Date: 2015-08-11

Lead Sponsor: Azienda Ospedaliera S. Maria della Misericordia

Target Recruit Count: 84

Registration Number: NCT01873378

Locations: 🇮🇹
Arbor Vitae Endoscopic Centre, Rome, Italy

Prevention of Ovarian Function Damage by a GnRH Analogue During Chemotherapy in Hodgkin Lymphoma Patients

Not Applicable

Completed

Conditions: Hodgkin Lymphoma
Hodgkin Disease

Interventions: Drug: triptorelin

First Posted Date: 2013-01-09

Last Posted Date: 2013-01-09

Lead Sponsor: Masaryk University

Target Recruit Count: 72

Registration Number: NCT01764230

Locations: 🇨🇿
Brno University Hospital and Masaryk University School of Medicine, Brno, Czech Republic

A Study of Immediate 9 Months Adjuvant Hormone Therapy With Triptorelin 11.25 mg Versus Active Surveillance After Radical Prostatectomy in High Risk Prostate Cancer Patients.

Phase 4

Completed

Conditions: Prostate Cancer

Interventions: Drug: Triptorelin 11.25 mg

First Posted Date: 2012-12-20

Last Posted Date: 2020-12-09

Lead Sponsor: Ipsen

Target Recruit Count: 226

Registration Number: NCT01753297

Locations: 🇨🇳
Chinese PLA General HospitalDepartment of UrologySite #156007, Beijing, China
🇨🇳
West China Hosspital, Sichuan UniversityDepartment of Urology Site #156008, Chengdu, China
🇨🇳
The First Affiliated Hospital of the 3th Military Medical University of PLA (Southwest Hospital) Site # 156010, Chongqing, China

and more 15 locations