Desloratadine
- Generic Name
- Desloratadine
- Brand Names
- Aerius, Clarinex, Clarinex-D, Neoclarityn, Desloratadine ratiopharm, Desloratadine Teva, Desloratadine Actavis, Dasselta, Azomyr
- Drug Type
- Small Molecule
- Chemical Formula
- C19H19ClN2
- CAS Number
- 100643-71-8
- Unique Ingredient Identifier
- FVF865388R
- Background
Desloratadine is a second generation, tricyclic antihistamine that which has a selective and peripheral H1-antagonist action. It is the active descarboethoxy metabolite of loratidine (a second generation histamine). Desloratidine has a long-lasting effect and does not cause drowsiness because it does not readily enter the central nervous system.
- Indication
For the relief of symptoms of seasonal allergic rhinitis, perennial (non-seasonal) allergic rhinitis. Desloratidine is also used for the sympomatic treatment of pruritus and urticaria (hives) associated with chronic idiopathic urticaria.
- Associated Conditions
- Allergic Rhinitis (AR), Asthma, Chronic Idiopathic Urticaria, Common Cold, Nasal Congestion, Perennial Allergic Rhinitis (PAR), Seasonal Allergic Rhinitis, Nasal symptoms, Non-nasal symptoms
- Associated Therapies
- Antihistamine
Antiplatelet Therapy in Chronic Urticaria
- Conditions
- Interventions
- First Posted Date
- 2024-02-20
- Last Posted Date
- 2024-02-21
- Lead Sponsor
- Chulalongkorn University
- Target Recruit Count
- 12
- Registration Number
- NCT06268470
- Locations
- 🇹🇭
Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Role of Desloratadine in Reducing Inflammation From Occupational Heat Strain
- Conditions
- Interventions
- First Posted Date
- 2022-07-06
- Last Posted Date
- 2022-07-06
- Lead Sponsor
- University of Victoria
- Target Recruit Count
- 12
- Registration Number
- NCT05446480
- Locations
- 🇨🇦
University of Victoria, Victoria, British Columbia, Canada
Fixed Dose Combination of Desloratadine / Prednisolone in the Treatment of Moderate Severe Allergic Rhinitis in Children
- Conditions
- Interventions
- First Posted Date
- 2022-01-31
- Last Posted Date
- 2024-08-07
- Lead Sponsor
- Eurofarma Laboratorios S.A.
- Target Recruit Count
- 248
- Registration Number
- NCT05214911
- Locations
- 🇧🇷
Eurofarma Laboratorios S.A, São Paulo, Brazil
Aprepitant vs. Desloratadine in EGFR-TKIs Related Pruritus Treatment
- Conditions
- Interventions
- First Posted Date
- 2016-01-05
- Last Posted Date
- 2021-05-18
- Lead Sponsor
- Sun Yat-sen University
- Target Recruit Count
- 138
- Registration Number
- NCT02646020
- Locations
- 🇨🇳
Cancer Center of Sun-Yat Sen University (CCSYSU), GuangZhou, Guangdong, China
Anti-inflammatory H1 Antihistamines Allergic Rhinitis
- First Posted Date
- 2015-07-24
- Last Posted Date
- 2015-07-24
- Target Recruit Count
- 115
- Registration Number
- NCT02507635
Anti-histamines and Methacholine Challenges.
- Conditions
- Interventions
- First Posted Date
- 2013-11-15
- Last Posted Date
- 2015-04-08
- Lead Sponsor
- Don Cockcroft
- Target Recruit Count
- 12
- Registration Number
- NCT01985789
- Locations
- 🇨🇦
University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Evaluation of the Inhibitory Effect of 5 Anti-Histamines in Urticaria
- Conditions
- Interventions
- First Posted Date
- 2013-09-12
- Last Posted Date
- 2014-02-19
- Lead Sponsor
- Grupo de Alergología Clínica y Experimental
- Target Recruit Count
- 150
- Registration Number
- NCT01940393
- Locations
- 🇨🇴
Medellin, Medellin, Antioquia, Colombia
An Efficacy and Safety Study of Desloratadine (MK-4117) in Japanese Participants With Chronic Urticaria (MK-4117-201)
- First Posted Date
- 2013-08-06
- Last Posted Date
- 2024-06-18
- Lead Sponsor
- Organon and Co
- Target Recruit Count
- 239
- Registration Number
- NCT01916967
Bioequivalence Study for Desloratadine OD Tablets 5 mg Under Fed Condition
- First Posted Date
- 2012-01-09
- Last Posted Date
- 2012-01-11
- Lead Sponsor
- Dr. Reddy's Laboratories Limited
- Target Recruit Count
- 36
- Registration Number
- NCT01506037
- Locations
- 🇺🇸
SFBC Ft Myers Inc, Broadway, Florida, United States
Bioequivalence Study for Desloratadine OD Tablets 5 mg Under Fasting Condition
- First Posted Date
- 2012-01-09
- Last Posted Date
- 2012-01-09
- Lead Sponsor
- Dr. Reddy's Laboratories Limited
- Target Recruit Count
- 35
- Registration Number
- NCT01506050
- Locations
- 🇺🇸
SFBC Ft Myers Inc, Broadway, Florida, United States
Drug Development Updates
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