Desloratadine
- Generic Name
- Desloratadine
- Brand Names
- Aerius, Clarinex, Clarinex-D, Neoclarityn, Desloratadine ratiopharm, Desloratadine Teva, Desloratadine Actavis, Dasselta, Azomyr
- Drug Type
- Small Molecule
- Chemical Formula
- C19H19ClN2
- CAS Number
- 100643-71-8
- Unique Ingredient Identifier
- FVF865388R
- Background
Desloratadine is a second generation, tricyclic antihistamine that which has a selective and peripheral H1-antagonist action. It is the active descarboethoxy metabolite of loratidine (a second generation histamine). Desloratidine has a long-lasting effect and does not cause drowsiness because it does not readily enter the central nervous system.
- Indication
For the relief of symptoms of seasonal allergic rhinitis, perennial (non-seasonal) allergic rhinitis. Desloratidine is also used for the sympomatic treatment of pruritus and urticaria (hives) associated with chronic idiopathic urticaria.
- Associated Conditions
- Allergic Rhinitis (AR), Asthma, Chronic Idiopathic Urticaria, Common Cold, Nasal Congestion, Perennial Allergic Rhinitis (PAR), Seasonal Allergic Rhinitis, Nasal symptoms, Non-nasal symptoms
- Associated Therapies
- Antihistamine
Multi-center, Pediatric, Open-label, Preference Study of Desloratadine 2.5 mg Reditab (SCH34117) and Zyrtec 5.0 mg Chewable Tablet Medications (Study P04574)(COMPLETED)
- First Posted Date
- 2008-10-24
- Last Posted Date
- 2022-02-09
- Lead Sponsor
- Organon and Co
- Target Recruit Count
- 217
- Registration Number
- NCT00779116
Observation of Side Effects and Effectiveness of Desloratadine (Aerius) Syrup in Filipino Children (Study P05634)
Completed
- Conditions
- Rhinitis, Allergic, SeasonalRhinitis, Allergic, PerennialUrticaria
- Interventions
- First Posted Date
- 2008-09-29
- Last Posted Date
- 2022-02-09
- Lead Sponsor
- Organon and Co
- Target Recruit Count
- 2980
- Registration Number
- NCT00761527
Safety of Desloratadine in Children With Allergy Sensitivity and Chronic Hives, Who Are Poor Metabolizers of Desloratadine (Study P02994)
Phase 3
Completed
- Conditions
- Chronic Idiopathic UrticariaAtopy
- Interventions
- Drug: Placebo
- First Posted Date
- 2008-09-23
- Last Posted Date
- 2024-08-15
- Lead Sponsor
- Organon and Co
- Target Recruit Count
- 97
- Registration Number
- NCT00757562
A Comparative Double-blind, Double-dummy Study of Desloratadine (DL) 5 mg Once Daily, Cetirizine 10 mg Once Daily, and Placebo Once Daily in Patients With Chronic Idiopathic Urticaria (Study P03736)
- First Posted Date
- 2008-09-11
- Last Posted Date
- 2024-08-15
- Lead Sponsor
- Organon and Co
- Target Recruit Count
- 149
- Registration Number
- NCT00751166
A Comparative Double-Blind, Double- Dummy Study of Desloratadine (DL) 5 MG Once Daily, Cetirizine 10 MG Once Daily, and Placebo Once Daily in Patients With Chronic Idiopathic Urticaria (Study P03735)
- First Posted Date
- 2008-09-11
- Last Posted Date
- 2024-08-15
- Lead Sponsor
- Organon and Co
- Target Recruit Count
- 174
- Registration Number
- NCT00751218
Evaluation of Desloratadine When Used in Patients With Either Allergic Rhinitis or Chronic Idiopathic Urticaria
- First Posted Date
- 2008-07-29
- Last Posted Date
- 2022-02-09
- Lead Sponsor
- Organon and Co
- Target Recruit Count
- 3011
- Registration Number
- NCT00724698
Safety of Aerius Syrup in Pediatric Patients Aged 1-5 Years Old With Allergic Rhinitis or Chronic Idiopathic Urticaria (Study P04446AM1)(COMPLETED)
- First Posted Date
- 2008-07-29
- Last Posted Date
- 2022-02-09
- Lead Sponsor
- Organon and Co
- Target Recruit Count
- 100
- Registration Number
- NCT00723736
Response of Desloratadine Syrup in the Relief of Symptoms Associated With Perennial Allergic Rhinitis in Pediatric Patients (Study P04299)
Completed
- Conditions
- Rhinitis
- Interventions
- First Posted Date
- 2008-06-25
- Last Posted Date
- 2022-02-09
- Lead Sponsor
- Organon and Co
- Target Recruit Count
- 591
- Registration Number
- NCT00704769
Efficacy of SLITone in House Dust Mite Allergic Patients
Phase 2
Completed
- Conditions
- Allergy
- Interventions
- Biological: SLITone(TM) Dermatophagoides mixBiological: PlaceboDrug: Budesonide/formoterol inhaler
- First Posted Date
- 2008-03-12
- Last Posted Date
- 2011-06-08
- Lead Sponsor
- ALK-Abelló A/S
- Target Recruit Count
- 124
- Registration Number
- NCT00633919
- Locations
- 🇪🇸
Fernando Rodríguez, Santander, Cantabria, Spain
A Study to Assess and Compare the Effects of 5 mg vs. 20 mg Desloratadine on the Development of Cold Urticaria Lesions
- First Posted Date
- 2008-01-25
- Last Posted Date
- 2008-01-25
- Lead Sponsor
- Charite University, Berlin, Germany
- Target Recruit Count
- 33
- Registration Number
- NCT00600847
- Locations
- 🇩🇪
Allergie-Centrum-Charité Berlin, Berlin, Germany
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