Lomustine
- Generic Name
- Lomustine
- Brand Names
- Ceenu, Gleostine
- Drug Type
- Small Molecule
- Chemical Formula
- C9H16ClN3O2
- CAS Number
- 13010-47-4
- Unique Ingredient Identifier
- 7BRF0Z81KG
- Background
An alkylating agent of value against both hematologic malignancies and solid tumors.
- Indication
For the treatment of primary and metastatic brain tumors as a component of combination chemotherapy in addition to appropriate surgical and/or radiotherapeutic procedures. Also used in combination with other agents as secondary therapy for the treatment of refractory or relapsed Hodgkin's disease.
- Associated Conditions
- Metastatic Brain Tumors, Primary Brain Neoplasm, Refractory Hodgkin Lymphoma
- Associated Therapies
- -
Combination Chemotherapy and Radiation Therapy With or Without Methotrexate in Treating Young Patients With Newly Diagnosed Gliomas
- First Posted Date
- 2006-01-18
- Last Posted Date
- 2013-12-19
- Target Recruit Count
- 150
- Registration Number
- NCT00278278
- Locations
- 🇺🇸
M. D. Anderson Cancer Center at University of Texas, Houston, Texas, United States
Radiation Therapy and Combination Chemotherapy in Treating Young Patients With Metastatic Medulloblastoma Who Have Undergone Surgery
- Conditions
- First Posted Date
- 2006-01-13
- Last Posted Date
- 2013-09-17
- Lead Sponsor
- Children's Cancer and Leukaemia Group
- Target Recruit Count
- 29
- Registration Number
- NCT00276666
- Locations
- 🇮🇪
Our Lady's Hospital for Sick Children Crumlin, Dublin, Ireland
🇬🇧Sir James Spence Institute of Child Health at Royal Victoria Infirmary, Newcastle-Upon-Tyne, England, United Kingdom
🇬🇧Great Ormond Street Hospital for Children, London, England, United Kingdom
Radiation Therapy Followed By Combination Chemotherapy in Treating Young Patients With Supratentorial Primitive Neuroectodermal Tumors
- Conditions
- First Posted Date
- 2006-01-11
- Last Posted Date
- 2013-08-02
- Lead Sponsor
- Children's Cancer and Leukaemia Group
- Target Recruit Count
- 30
- Registration Number
- NCT00274911
- Locations
- 🇮🇪
Our Lady's Hospital for Sick Children Crumlin, Dublin, Ireland
🇬🇧Birmingham Children's Hospital, Birmingham, England, United Kingdom
🇬🇧Royal London Hospital, London, England, United Kingdom
Radiation Therapy, Temozolomide, and Lomustine in Treating Young Patients With Newly Diagnosed Gliomas
- First Posted Date
- 2005-01-07
- Last Posted Date
- 2023-02-15
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 118
- Registration Number
- NCT00100802
- Locations
- 🇺🇸
Children's Oncology Group, Philadelphia, Pennsylvania, United States
Chemotherapy, Filgrastim, and Radiation Therapy in Treating Patients With Primary Central Nervous System Lymphoma
- Conditions
- First Posted Date
- 2004-07-26
- Last Posted Date
- 2012-03-20
- Lead Sponsor
- Case Comprehensive Cancer Center
- Registration Number
- NCT00003929
- Locations
- 🇺🇸
Ireland Cancer Center at University Hospitals Case Medical Center, Case Comprehensive Cancer Center, Cleveland, Ohio, United States
Comparison of Radiation Therapy Regimens in Combination With Chemotherapy in Treating Young Patients With Newly Diagnosed Standard-Risk Medulloblastoma
- Conditions
- Interventions
- First Posted Date
- 2004-06-16
- Last Posted Date
- 2024-11-05
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 549
- Registration Number
- NCT00085735
- Locations
- 🇺🇸
University of Alabama at Birmingham Cancer Center, Birmingham, Alabama, United States
🇺🇸Banner University Medical Center - Tucson, Tucson, Arizona, United States
🇺🇸Kaiser Permanente Downey Medical Center, Downey, California, United States
Chemotherapy Followed by Radiation Therapy in Treating Adults With Supratentorial Glioma
- Conditions
- Interventions
- First Posted Date
- 2004-05-26
- Last Posted Date
- 2016-07-13
- Lead Sponsor
- Alliance for Clinical Trials in Oncology
- Target Recruit Count
- 43
- Registration Number
- NCT00002806
- Locations
- 🇺🇸
CCOP - Toledo Community Hospital Oncology Program, Toledo, Ohio, United States
🇺🇸CCOP - Metro-Minnesota, Saint Louis Park, Minnesota, United States
🇺🇸Siouxland Hematology-Oncology, Sioux City, Iowa, United States
Radiation Therapy Plus Combination Chemotherapy in Treating Children With Medulloblastoma
- First Posted Date
- 2004-05-24
- Last Posted Date
- 2014-08-01
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 421
- Registration Number
- NCT00002875
- Locations
- 🇺🇸
Children's Hospital Los Angeles, Los Angeles, California, United States
🇺🇸Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, United States
🇺🇸Ireland Cancer Center, Cleveland, Ohio, United States
Combination Chemotherapy and Bone Marrow Transplantation or Peripheral Stem Cell Transplantation in Treating Patients With Oligodendroglioma
- Conditions
- First Posted Date
- 2004-05-21
- Last Posted Date
- 2013-06-25
- Lead Sponsor
- Memorial Sloan Kettering Cancer Center
- Target Recruit Count
- 60
- Registration Number
- NCT00003101
- Locations
- 🇺🇸
Memorial Sloan-Kettering Cancer Center, New York, New York, United States
🇺🇸University of Alabama Comprehensive Cancer Center, Birmingham, Alabama, United States
🇺🇸Evanston Northwestern Health Care, Evanston, Illinois, United States
Combination Chemotherapy Plus Gene Therapy in Treating Patients With CNS Tumors
- Conditions
- Interventions
- First Posted Date
- 2004-04-28
- Last Posted Date
- 2015-03-25
- Lead Sponsor
- Indiana University
- Target Recruit Count
- 10
- Registration Number
- NCT00005796
- Locations
- 🇺🇸
Indiana University Cancer Center, Indianapolis, Indiana, United States
🇺🇸Dana-Farber Cancer Institute, Boston, Massachusetts, United States
Drug Development Updates
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